HOME >> MEDICINE >> NEWS
Intensive statin therapy reduces amount of plaque buildup in arteries compared to moderate treatment

Patients with coronary heart disease who received intensive lipid-lowering treatment had less progression of coronary atherosclerosis (plaque buildup in the arteries) than patients treated with a moderate lipid-lowering regimen, according to a study in the March 3 issue of The Journal of the American Medical Association (JAMA).

According to background information in the article, statin drugs (lipid-lowering medications) have been shown to reduce both atherogenic (development of plaque in arterial walls) lipoproteins and cardiovascular illness and death. However, the optimal approach and target level for lipid reduction with statins in patients with established coronary artery disease (CAD) remains uncertain.

Steven E. Nissen, M.D., of the Cleveland Clinic Lerner School of Medicine, Cleveland, and colleagues compared the effects of two statin regimens. The Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) study was a double-blind, randomized trial at 34 centers in the United States. Intravascular ultrasound, which provides detailed images within a blood vessel, was used to measure plaque buildup in the wall of the coronary arteries.

Between June 1999 and September 2001, 654 patients were randomized and received a study drug; 502 had intravascular ultrasound examinations at baseline and after 18 months of treatment. Patients were randomly assigned to receive a regimen designed to moderately reduce low-density lipoprotein cholesterol (LDL-C) using 40 mg of pravastatin, or an intensive LDL-C lowering regimen, using 80 mg of atorvastatin.

The researchers found that patients with moderate cholesterol levels who received 18 months of intensive lipid-lowering therapy had greater reductions in LDL-cholesterol than patients who received the moderate lipid lowering regimen, and also had greater reductions in C-reactive protein (a measure of inflammation). Patients in the intensive therapy group also showed signific
'"/>

Contact: Alicia Sokol
216-445-9661
JAMA and Archives Journals
2-Mar-2004


Page: 1 2

Related medicine news :

1. Intensive diabetes management yields positive results, according to Pittsburgh project
2. Intensive care specialists reduce hospital death rates by 30 percent
3. Intensive care treatment may be bad for your health
4. Intensive exercise improves bodys ability to process blood sugars
5. Intensive training may not be as bad for young women as previously thought
6. Intensive Care Before A Major Op May Improve Survival
7. NHLBI Clinical Trial Stopped Early: Successful Ventilator Strategy Found For Intensive Care Patients On Life Support
8. Intensive Program Can Help Premature Babies Learn At the Start
9. Study Finds Less Intensive Treatments May Not Maintain HIV Suppression
10. About The Care Of Patients Before They Are Admitted To Intensive Care
11. Duke Physicians Find Intensive Radiation Therapy Can Save Lives, Improve Quality Of Life For Patients With Head And Neck Cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally recognized health ... expanded their existing home health joint venture through an agreement, effective October 1, ... joint venture home health company with Asante, delivering clinically integrated care, for the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... has recently contributed a medical article to the newly revamped Cosmetic Town ... article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... been named one of Michigan’s 2017 Best and Brightest in Wellness® by Best ... in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: ... data solutions, today announced that its MyDario product is expected to appear ... listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, The ... ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
Breaking Medicine Technology:
Cached News: