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Intensive statin therapy reduces amount of plaque buildup in arteries compared to moderate treatment

antly less progression of coronary atherosclerosis in comparison with patients who received a more moderate regimen. The change in volume of plaque buildup was positive in the pravastatin group (2.7 percent), indicating net progression compared with the baseline measurement, whereas in the atorvastatin group, the change was negative (-0.4 percent), showing no disease progression since baseline.

"These findings have potential implications for treatment guidelines for patients with dyslipidemia and established CAD," the authors write. "A more intensive lipid-lowering therapy is required than is currently recommended by national and international guidelines to obtain maximal reduction in the progression of coronary atherosclerosis," the researchers conclude.
(JAMA. 2004;291:1071-1080. Available post-embargo at JAMA.com.)


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Contact: Alicia Sokol
216-445-9661
JAMA and Archives Journals
2-Mar-2004


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