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Interleukin-2 Boosts Cancer Vaccine Effectiveness In Mice

eated with the vaccine/IL-2 combination had fewer than 10 nodules compared to greater than 250 nodules in control mice. (Note photo availability.)

  • Mice with well-established secondary lung tumors receiving vaccine in combination with IL-2 lived more than twice as long as mice receiving vaccine or IL-2 alone.

  • Even mice with large, late-stage sarcomas showed regression in tumor size after combination treatment and lived significantly longer than mice receiving either the vaccine or IL-2 alone. While other researchers are experimenting with tumor vaccines made from single tumor peptides mixed with dendritic cells, Mulé and his colleagues use whole tumors called lysates---tumor cells which have been frozen and thawed several times to kill them. "By using the entire tumor cell, we are sensitizing the immune system to attack all the antigens in that tumor, making it less likely that tumor cells will escape detection," he said.

    In addition to Mulé, co-authors on the PNAS study are Koichi Shimizu, M.D., U-M research fellow; Ryan C. Fields, who received his U-M undergraduate degree in 1998 and is now attending Duke University Medical School; and Martin Giedlin, associate research director for vaccines and gene therapy research at Chiron Technologies.

    The research was supported by the National Cancer Institute/National Institutes of Health, the U.S. Army Research Office and by gifts from C.J. and E.C. Aschauer and Abbott Laboratories to the U-M's Department of Surgery and the Tumor Immunotherapy Program.


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    • Contact: Sally Pobojewski
    pobo@umich.edu
    734-647-1844
    University of Michigan
    2-Mar-1999


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