HOME >> MEDICINE >> NEWS
International MRC trial finds a routine treatment for head injury may do more harm than good

A major, international Medical Research Council (MRC) trial has found that a routine treatment for patients with head injuries, widely used around the world for the last 30 years, does not improve survival rates and may do more harm than good. The results of the study are published in full in this week's edition of The Lancet.

Every year millions of people world-wide are treated for serious head injury. One in five die and a substantial proportion are permanently disabled.

Previous studies suggested that giving patients anti-inflammatory treatments called corticosteroids could reduce deaths by preventing the potentially lethal brain swelling that occurs after head injury. But these studies were too small to be able to provide definitive evidence of benefit.

The MRC CRASH* trial was specifically designed to answer this question and with over ten thousand patients recruited from nearly 50 countries is the largest head injury trial ever conducted.

The trial, co-ordinated by researchers from the London School of Hygiene and Tropical Medicine and the Universities of Manchester, Edinburgh, Birmingham, and Oxford, compared patients treated with corticosteroids with patients on a placebo treatment. They found that 21 per cent of those given the corticosteroids died within two weeks compared with 18 per cent of those on the placebo treatment.

When the team looked specifically at whether the severity of injury or how quickly the treatments were administered might affect the outcome, they found no change in the effect.

Patients were only eligible to take part in the trial if, on admission to casualty, their doctor was uncertain whether or not to treat them with corticosteroids. In addition to the usual emergency medical care, the patients were randomly allocated to either corticosteroids or a placebo treatment. Both treatments were delivered by a drip over a 48 hour period.

Dr. Ian Roberts, the clinical co-ord
'"/>

Contact: Makeda Scott
makeda.scott@fco.gov.uk
202-588-6523
British Information Services
8-Oct-2004


Page: 1 2

Related medicine news :

1. International breast cancer prevention study launches in the United States and Canada
2. National Academies advisory: May 2 Symposium on International Science Policy
3. Awards & fellowships at the International & American Association for Dental Research General Session
4. Lectures, keynoters, symposia highlight International Dental Research meeting
5. Advances in Uterine Leiomyoma Research: 2nd NIH International Congress
6. International gathering of experts to share retinoblastoma breakthroughs
7. International trial of two microbicides begins
8. International gathering at UH examines top computer code
9. International trial finds benefits of breast MRI in women at high risk
10. International study provides culture-by-culture clues to family violence and abuse
11. St. Jude scientist wins International Society of Experimental Hematology award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... ... 2018 , ... Gastro Health, LLC (“Gastro Health”), one of ... Simon Frisch and Chris Weinstein, who have been appointed Senior Vice President, Strategic ... time of tremendous growth for the group, which has increased its physician headcount ...
(Date:8/14/2018)... ... August 14, 2018 , ... Eagle Merchant ... a leading provider of residential and commercial recreational surfacing products across the country. ... with products used across a wide range of markets and customers. Founded in ...
(Date:8/11/2018)... OVERLAND PARK, Kan. (PRWEB) , ... August 10, ... ... Gout Gone, an industry leader in Gout Relief. , What is gout? This ... the lower extremities as a result of high levels of uric acid. Other ...
(Date:8/11/2018)... ... August 11, 2018 , ... Financial Voyages LLC CEO Pamela ... of the Year-Business category in The 15th Annual International Business Awards®. , The ... organizations worldwide – public and private, for-profit and non-profit, large and small - ...
(Date:8/9/2018)... ... August 09, 2018 , ... Balboa ... a new verification process that substance abuse providers must pass in order to ... can reach more people to help.” , Helping people is what Balboa ...
Breaking Medicine News(10 mins):
(Date:8/15/2018)... (PRWEB) , ... August 15, 2018 , ... ... to their expansive lineup of casters. The newly designed Diamond Series features ... and stability. Manufactured with an antimicrobial compound injected into a thermoplastic resin ...
(Date:8/14/2018)... OXNARD, Calif. (PRWEB) , ... August 14, 2018 ... ... completion of Harvest Academy, their first-ever summer harvest employment and hands-on educational program ... were currently enrolled in a high school, junior college or university, spent a ...
(Date:8/11/2018)... ... August 11, 2018 , ... ... Monday, August 13, with fun, games and gifts. Left-Handers are possibly the world’s ... for right-handers. Having endured centuries of prejudice, countless indignities and inconveniences, left-handers quietly ...
Breaking Medicine Technology:
Cached News: