HOME >> MEDICINE >> NEWS
Investigational drug may protect cancer and AIDS patients from side effects of pain relief therapy

A drug developed to relieve one of the major side effects of pain therapy for cancer patients may offer an added benefit for AIDS patients, researchers from the University of Chicago and the Children's Hospital of Philadelphia reported Saturday, October 11, at the 2003 Annual Meeting of the American Society of Anesthesiologists in San Francisco.

Methylnaltrexone (MNTX) was invented to reverse the constipation caused by powerful opioid-based pain relievers such as morphine, OxyContin or Percocet taken by patients with cancer or AIDS. Opiates also appear to increase the ability of HIV to infect certain immune system cells.

This laboratory study found that MNTX blocked increases in HIV entry and replication that occur when immune cells are exposed to therapeutic doses of morphine. In this in-vitro study, very small amounts of methylnaltrexone blocked this process.

"If our studies are borne out in future clinical trials, methylnaltrexone may improve the care of patients who take opioids for pain caused by AIDS," said Jonathan Moss, M.D., Ph.D., professor of anesthesia and critical care at the University of Chicago and director of the study.

Many AIDS patients and more than 500,000 patients with advanced cancer depend on drugs like morphine for pain relief. One side effect of these pain relievers is severe constipation, which can be so distressing that many patients discontinue their pain medication.

Methylnaltrexone was invented to solve this problem by the late Leon Goldberg, a University of Chicago pharmacologist. To help a dying friend with morphine-induced constipation, Goldberg took naltrexone, an established drug that blocks the effects of morphine, and altered it slightly so that it could no longer cross the protective barrier that surrounds the brain.

Consequently, it did not interfere with morphine's effect on pain, which is centered in the brain, but it did block morphine's effects on gut motility, which a
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
14-Oct-2003


Page: 1 2

Related medicine news :

1. Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects
2. Investigational drug may provide new option for preventing transplant organ rejection
3. Investigational drug brings new hope to kidney cancer patients
4. Investigational mesh jackets studied as an experimental therapy for heart failure
5. Investigational oral contraceptive reduces premenstrual and menstrual symptoms
6. Investigational drug study may determine if lung cancer is preventable in cigarette smokers
7. New study in Nature demonstrates protection against cell death during heart attack
8. Simple intervention encourages sun protection behaviors
9. Red wine protects the heart
10. Sunflower seed oil can protect low birth weight babies from infection
11. Physical activity linked to protection from Parkinsons disease

Post Your Comments:
(Date:11/23/2014)... November 23, 2014 The FDA is ... Common, **FDAnews On-Demand Webinar**, Dec. 11, 2014 ? Any ... The FDA’s focus on promotional activities is no longer ... Now they're looking at websites, Twitter, journal articles, TV ... for Thursday, Dec. 11, for On-Demand access to Timothy ...
(Date:11/23/2014)... Utah (PRWEB) November 23, 2014 ... insurance reimbursement for small businesses, announced their new ... The End of Employer-Provided Health Insurance. ... is the greatest financial risk facing most American ... U.S. employers, small and large, when it comes ...
(Date:11/22/2014)... PrettyTailor , an outstanding dress company, has recently updated ... buy new dresses at its online shop now. For ... As a matter of fact, PrettyTailor specializes in beautiful ... types of wedding outfits, including bridesmaid dresses, mother of ... provides a variety of occasion dresses, such as cocktail ...
(Date:11/22/2014)... BambooFlooringChina.com is a famous brand in ... its new collection of bamboo mats ; the new ... off. , According to the sales manager of ... it a highly renewable resource. Their bamboo mats are 100% ... which comes from natural bamboo with caramel bamboo strips. ...
(Date:11/22/2014)... Discount-Dress.com is an important company in the dress ... the company’s online market share by a series of promotions. ... and announced a bridesmaid dress promotion for the new year ... All the dresses from this company are not only of ... is very good at manufacturing wedding dresses. Customers prefer to ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 3Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 5Health News:Zane Benefits, Inc. Announces New Webinar on The End of Employer-Provided Health Insurance Now Available On-Demand! 2Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2
(Date:11/22/2014)... --  Long Beach dentist , Dr. Rassouli, is now offering ... in tooth replacement because they offer the closest match to ... and preserve smiles and improve overall dental health. Dr. Rassouli ... as a part of a smile makeover or full mouth ... smile. The loss of a tooth can lead ...
(Date:11/22/2014)... Nov. 21, 2014  Particle Sciences, Inc (PSI), ... developed and manufactured a new innovative vaginal ring ... and Development arm of Exeltis Pharmaceuticals.  According to ... Management at Particle Sciences, "This vaginal ring was ... material sciences and modeling expertise.  We are thrilled ...
(Date:11/21/2014)... WALTHAM, Mass. , Nov. 21, 2014  Alere ... in rapid diagnostic tests, has appointed Juliet Cunningham ... created role, Cunningham will be responsible for driving communications ... to execute on a series of changes to increase ... our progress to investors," said Namal Nawana, Chief Executive ...
Breaking Medicine Technology:Long Beach Dentist, Dr. Rassouli, is Now Offering Dental Implants 2Particle Sciences' Clinical Trial Supplies Group Manufactures Innovative Vaginal Ring 2Alere Appoints Juliet Cunningham to Lead Investor Relations 2
Cached News: