Investigational drug may protect cancer and AIDS patients from side effects of pain relief therapy

A drug developed to relieve one of the major side effects of pain therapy for cancer patients may offer an added benefit for AIDS patients, researchers from the University of Chicago and the Children's Hospital of Philadelphia reported Saturday, October 11, at the 2003 Annual Meeting of the American Society of Anesthesiologists in San Francisco.

Methylnaltrexone (MNTX) was invented to reverse the constipation caused by powerful opioid-based pain relievers such as morphine, OxyContin or Percocet taken by patients with cancer or AIDS. Opiates also appear to increase the ability of HIV to infect certain immune system cells.

This laboratory study found that MNTX blocked increases in HIV entry and replication that occur when immune cells are exposed to therapeutic doses of morphine. In this in-vitro study, very small amounts of methylnaltrexone blocked this process.

"If our studies are borne out in future clinical trials, methylnaltrexone may improve the care of patients who take opioids for pain caused by AIDS," said Jonathan Moss, M.D., Ph.D., professor of anesthesia and critical care at the University of Chicago and director of the study.

Many AIDS patients and more than 500,000 patients with advanced cancer depend on drugs like morphine for pain relief. One side effect of these pain relievers is severe constipation, which can be so distressing that many patients discontinue their pain medication.

Methylnaltrexone was invented to solve this problem by the late Leon Goldberg, a University of Chicago pharmacologist. To help a dying friend with morphine-induced constipation, Goldberg took naltrexone, an established drug that blocks the effects of morphine, and altered it slightly so that it could no longer cross the protective barrier that surrounds the brain.

Consequently, it did not interfere with morphine's effect on pain, which is centered in the brain, but it did block morphine's effects on gut motility, which a

Contact: John Easton
University of Chicago Medical Center

Page: 1 2

Related medicine news :

1. Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects
2. Investigational drug may provide new option for preventing transplant organ rejection
3. Investigational drug brings new hope to kidney cancer patients
4. Investigational mesh jackets studied as an experimental therapy for heart failure
5. Investigational oral contraceptive reduces premenstrual and menstrual symptoms
6. Investigational drug study may determine if lung cancer is preventable in cigarette smokers
7. New study in Nature demonstrates protection against cell death during heart attack
8. Simple intervention encourages sun protection behaviors
9. Red wine protects the heart
10. Sunflower seed oil can protect low birth weight babies from infection
11. Physical activity linked to protection from Parkinsons disease

Post Your Comments:
(Date:10/9/2015)... ... , ... "As a nurse, I care for male patients who struggle with ... large diapers or pads. We came up with this as a better alternative to ... from the tip of the penis. This prevents stains from forming on underwear and ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... Santa Rosa ... their partnership as MD Anderson prepares to go-live on the Epic platform in March ... for early 2016. Santa Rosa will execute the contract by supporting Scheduling Appointment Conversion ...
(Date:10/9/2015)... , ... October 09, 2015 , ... Most people assume ... with more vegetables and less meat. While noted T’ai Chi Master and integrative medicine ... and Yang” relationship between the two cuisines and that they potentially complement one another, ...
(Date:10/9/2015)... ... 09, 2015 , ... The Kitchenistas of National City, a documentary film on ... conditions related to food, has been selected for viewing at the I Imagine Film ... Festival on October 30-31 in London, England. , The documentary, by San Diego filmmaker ...
(Date:10/9/2015)... ... 2015 , ... When the producers of the popular ‘Ask This Old House’ ... Hollywood, CA, they turned to a trusted resource in Tamarack Technologies. , “Our HV ... because of our successful past experience with the show they enlisted our help,” said ...
Breaking Medicine News(10 mins):
(Date:10/8/2015)... of investigation, Ross Feller Casey , LLP has filed ... Xarelto,s recommended dosage doesn,t work for as long as promised, ... on behalf of a Florida man ... as the manufacturer suggested. Ross Feller Casey is ... clients from across the country with similar claims. --> ...
(Date:10/8/2015)... , Oct. 08 2015 ... the addition of the "Natural Language ... Sciences Industry by Type (Rule-Based, Statistical, & ... Asia-Pacific, Middle East and Africa, Latin America) ... to their offering. --> http://www.researchandmarkets.com/research/pvzb7x/natural_language ...
(Date:10/8/2015)... WASHINGTON , Oct. 8, 2015  CareDx, Inc. (NASDAQ: ... a reversal of a recent proposal by the Centers for ... its FDA-cleared diagnostic test AlloMap, which measures gene expression levels ... organ rejection. See latest coverage of this story ... See latest coverage of this story on CNBC ...
Breaking Medicine Technology:
Cached News: