HOME >> MEDICINE >> NEWS
Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects

ATLANTA Physician-researchers at Emory University in Atlanta have shown an investigational medication, known as LEA29Y (belatacept), is effective in preserving transplanted kidney function while at the same time avoiding the toxic side effects that are common in the currently used long-term, immunosuppressive transplant medications. The pre-clinical research conducted with nonhuman primates at the Yerkes National Primate Research center was an important step in establishing human clinical trials to develop an effective alternative to current anti-rejection therapies. Findings from one of the nonhuman primate studies appear in the March issue of the American Journal of Transplantation, which currently is online and appeared in print on February 21.

More than 23,000 organ transplants are performed each year in the United States. While current immunosuppressant medications have reduced the incidence of early organ failure following transplants, measures to prevent late failure and to halt other diseases that result from toxic side effects of current treatments have been limited.

Cyclosporine, the current standard of care following organ transplantation, prevents initial organ rejection by effectively blocking certain immune system pathways that are activated when the body detects foreign cells. At the same time, though, cyclosporine indiscriminately targets and blocks other cellular signal pathways, causing serious side effects such as high blood pressure and cholesterol, which may lead to cardiovascular disease, and high kidney toxicity that ultimately leads to long-term renal failure. In addition, long-term cyclosporine use damages the body's immune system and prevents it from fighting off other infections following transplant.

"For the past 20 years, transplant patients have been treated with cyclosporine-like medications that effectively suppressed the immune system to prevent the body from rejecting the new organ," said Christian
'"/>

Contact: Lisa Newbern
lmnewbe@emory.edu
404-727-7709
Emory University Health Sciences Center
22-Feb-2005


Page: 1 2

Related medicine news :

1. Investigational drug may provide new option for preventing transplant organ rejection
2. Investigational drug brings new hope to kidney cancer patients
3. Investigational drug may protect cancer and AIDS patients from side effects of pain relief therapy
4. Investigational mesh jackets studied as an experimental therapy for heart failure
5. Investigational oral contraceptive reduces premenstrual and menstrual symptoms
6. Investigational drug study may determine if lung cancer is preventable in cigarette smokers
7. Success of liver transplantation may be most influenced by three risk factors
8. Alcohol relapse adversely affects 10-year liver transplant survival
9. Donor age has no affect on long-term liver transplant survival
10. Age shouldnt be a factor in kidney transplantation
11. Cornea transplants can be improved

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... The American Medical Spa Association ... 7, to Saturday, April 10, 2021, at Wynn Las Vegas. The event had ... trade show for non-invasive medical aesthetic practices that brings together owners, physicians, nurse ...
(Date:9/1/2020)... ... September 01, 2020 , ... KitoTech ... million convertible note financing, which will be used to accelerate the commercialization of ... this financing, the company will continue to expand its customer base of healthcare ...
(Date:8/31/2020)... ... August 31, 2020 , ... The Lymphoma Research Foundation ... lymphoma research and serving the lymphoma community through a comprehensive series of education ... Blood Cancer Awareness Month (BCAM) and its international Light it Red for ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... opportunities through high-quality, career-relevant, and affordable online education – is proud to announce ... , Among the first of its kind in the nation, the 60-credit hour ...
(Date:8/31/2020)... Calif. (PRWEB) , ... August 31, 2020 , ... ... leadership experience working, both directly with persons with autism and other developmental disabilities, ... expertise includes early intervention, parent education, adolescents with autism, school consultation, and staff ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Continuing on its rapid ... sanitization, disinfection and deodorization provider - is proud to announce it has opened ... for businesses and residents throughout the area. , Germinator provides a 100% safe ...
(Date:8/27/2020)... Pa. (PRWEB) , ... August 27, 2020 , ... ... care coordination software, today announced the successful completion of their 2020 System and ... well as their HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect ...
(Date:8/27/2020)... (PRWEB) , ... August 27, 2020 , ... Bridge To ... Directors. Dr. Friedman is an adult and pediatric neuro-oncologist who serves on the Board ... as an educator at Duke University Medical School. , Internationally recognized, Dr. Friedman is ...
Breaking Medicine Technology:
Cached News: