HOME >> MEDICINE >> NEWS
Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects

ATLANTA Physician-researchers at Emory University in Atlanta have shown an investigational medication, known as LEA29Y (belatacept), is effective in preserving transplanted kidney function while at the same time avoiding the toxic side effects that are common in the currently used long-term, immunosuppressive transplant medications. The pre-clinical research conducted with nonhuman primates at the Yerkes National Primate Research center was an important step in establishing human clinical trials to develop an effective alternative to current anti-rejection therapies. Findings from one of the nonhuman primate studies appear in the March issue of the American Journal of Transplantation, which currently is online and appeared in print on February 21.

More than 23,000 organ transplants are performed each year in the United States. While current immunosuppressant medications have reduced the incidence of early organ failure following transplants, measures to prevent late failure and to halt other diseases that result from toxic side effects of current treatments have been limited.

Cyclosporine, the current standard of care following organ transplantation, prevents initial organ rejection by effectively blocking certain immune system pathways that are activated when the body detects foreign cells. At the same time, though, cyclosporine indiscriminately targets and blocks other cellular signal pathways, causing serious side effects such as high blood pressure and cholesterol, which may lead to cardiovascular disease, and high kidney toxicity that ultimately leads to long-term renal failure. In addition, long-term cyclosporine use damages the body's immune system and prevents it from fighting off other infections following transplant.

"For the past 20 years, transplant patients have been treated with cyclosporine-like medications that effectively suppressed the immune system to prevent the body from rejecting the new organ," said Christian
'"/>

Contact: Lisa Newbern
lmnewbe@emory.edu
404-727-7709
Emory University Health Sciences Center
22-Feb-2005


Page: 1 2

Related medicine news :

1. Investigational drug may provide new option for preventing transplant organ rejection
2. Investigational drug brings new hope to kidney cancer patients
3. Investigational drug may protect cancer and AIDS patients from side effects of pain relief therapy
4. Investigational mesh jackets studied as an experimental therapy for heart failure
5. Investigational oral contraceptive reduces premenstrual and menstrual symptoms
6. Investigational drug study may determine if lung cancer is preventable in cigarette smokers
7. Success of liver transplantation may be most influenced by three risk factors
8. Alcohol relapse adversely affects 10-year liver transplant survival
9. Donor age has no affect on long-term liver transplant survival
10. Age shouldnt be a factor in kidney transplantation
11. Cornea transplants can be improved

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... 2020 , ... JNL Technologies Inc. , a manufacturer of safety and ... SafeHealth screening software. This tool allows companies to create an electronic screening record ... of additional paperwork management. , SafeHealth allows you to create a custom set of ...
(Date:5/16/2020)... ... May 15, 2020 , ... For patients who have gone to see Andy Gaertner, ... office has always had in place. After being allowed to re-open during the current pandemic, ... and staff are as safe and comfortable as possible while going through their dental exams ...
(Date:5/16/2020)... YORK (PRWEB) , ... May 15, 2020 , ... ... has announced a new collaboration with the Open Source Medical Supplies (OSMS). The ... support of their efforts to reduce the spread of COVID-19. , Created as ...
(Date:5/15/2020)... ... ... COVID-19 has made people feel fearful, but Rieke Office Interiors (ROI) is helping ... to work safely. Their unique line of SafeSpace™ PPE equipment for the office has ... , Everyone needs to be able to get back to work and to know ...
(Date:5/15/2020)... ... 2020 , ... Cisive, a global provider of compliance-driven human ... background screening division, PreCheck, were both named by HR Tech Outlook magazine as ... comprising of CEOs, CIOs, CHROs, and analysts, along with HR Tech Outlook’s editorial ...
Breaking Medicine News(10 mins):
(Date:5/27/2020)... N.J. (PRWEB) , ... 27, 2020 , ... Top Docs have been reviewed and approved in April 2020: , CARDIOLOGY, Passaic County, ... Peter Ferraro , Dr. Mansoo Jo , Dr. Mi Jo , ... Dr. Jeffrey Rapaport , FAMILY PRACTICE, Camden County, ...
(Date:5/27/2020)... ... ... Away Free CBD Supplements for the next 60 days , Hemp Health One is giving ... giveaway contest on its Instagram and Facebook pages. , The rules to play ... page. Then, like the most recent post, share it, or tag a friend. The winner ...
(Date:5/26/2020)... ... 26, 2020 , ... Melwood is proud to be donating thousands of vegetable ... pantries, group homes and nursing homes. “It’s more important than ever to reach out ... and bring a little cheer to seniors and individuals of differing abilities,” said Melwood’s ...
Breaking Medicine Technology:
Cached News: