Irvine chemist wins national award for new drug techniques

Larry E. Overman of Corona del Mar, Calif., will be honored Sept. 9 by the world's largest scientific society for inventing new ways to make molecules, particularly those that drug companies use to study and treat disease. He will receive the 2003 Arthur C. Cope Award from the American Chemical Society at its national meeting in New York.

A single drug can have several, and sometimes harmful, side effects thus doctors often prescribe cycles of chemotherapy and rest to avert damage to their patients' immune systems, for example.

"Particularly in the pharmaceutical industry one wants to have increasing selectivity in regulating a pathway or target," said Overman, an organic chemist at the University of California, Irvine. "That desire drives increasingly complex chemical structures of drugs and places a major challenge on those who design and manufacture them."

Giving drug designers the tools to make such products is the aim of Overman's research. "What my laboratory does is engineer and invent new chemical reactions that make structures that are by nature drug-like, and make them efficiently," he said.

Overman often works with particular target molecules in mind. For example, a class of promising anti-cancer agents, discovered in Mediterranean sea sponges, caught his eye about 10 years ago, he said. Over the next eight years his group became the first, and so far the only, to make the compounds in the laboratory from simple starting materials. His synthesis has since been licensed by a Spanish pharmaceutical company interested in studying the drug candidates.

Over the last three decades he has "contributed more than 60 complex total syntheses to the literature" and "virtually all these syntheses contain pivotal reactions methods developed within the Overman group," noted a colleague in nominating him for the award.

As a boy growing up in the Midwest, Overman "was the opposite of a chemistry-set kid," he said. "I had a

Contact: Sharon Worthy
American Chemical Society

Page: 1 2

Related medicine news :

1. UC Irvines undergraduate research programs receive $900,000 funding boost
2. Dec. 10-12 Japanese-American Frontiers of Science Meeting in Irvine, Calif.
3. National Academies advisory: Nov. 4-6 Frontiers of Science meeting in Irvine, Calif.
4. Irvine researcher receives national award
5. NJIT chemistry professor edits text outlining best laboratory practices
6. Changing chemistry helps explain estrogen threat to the heart
7. Sealing corneal incisions with a drop of chemistry, BU researchers develop gel for cataract surgery
8. Herbal supplements testing topic of discussion at chemistry meeting March 30
9. Hopkins Peter Agre receives 2003 Nobel Prize in chemistry
10. Three Abbott chemists honored as Heroes for development of HIV therapy for children
11. Oregon State chemist wins national award for synthesizing molecules in nature

Post Your Comments:

(Date:9/17/2019)... ... ... Milwaukee-area dealership Hall Cars has hosted an annual event each fall for years in an ... Cancer,” entails that for every vehicle purchased from Sept. 17 to Nov. 14, the dealership ... days, it has also been referred to as, “50 for 50.” , Though the ...
(Date:9/17/2019)... ... September 17, 2019 , ... Dr. Jacqueline Subka ... laser dentistry . A minimally invasive approach to gum surgery, laser dentistry is ... Laser dentistry is gentle and effective because it simply uses laser light to ...
(Date:9/17/2019)... ... September 17, 2019 , ... Dr. Perry Patel, ... been certified by the American Academy of Facial Esthetics (AAFE) to administer Botox ... range of orofacial conditions such as tooth clenching and grinding, tongue tension, temporomandibular ...
(Date:9/17/2019)... , ... September 17, 2019 ... ... the October 18 "Pacifica Experience" Open House day on Pacifica's Lambert Campus, ... degree programs in Depth Psychology, the Humanities, Clinical Psychology, Counseling Psychology, and ...
(Date:9/11/2019)... ... September 11, 2019 , ... Workplace injuries cost individuals, ... solve injury risks which lead to musculoskeletal disorders (MSDs). , Starting with ... the team at Soter Analytics helps avoid ergonomic injury by coaching ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... ... , ... Summer is a time for barbecues, parties and picnics and lots of delicious food ... Douglas Ng, family dentist in San Luis Obispo has some tips for healthy ... popsicles and ice-filled cold drinks to go along with the hot dogs, hamburgers, corn on ...
(Date:9/17/2019)... ... 2019 , ... Dr. Babis Rammos, a renowned plastic surgeon ... Beauty Network, well known for its exclusive and luxurious lifestyle publication Haute Living ... newest addition to the Haute Beauty members-only network. , Haute Beauty offers a ...
(Date:9/14/2019)... ... September 13, 2019 , ... ... in Montreal provided a plethora of breakthrough research studies including several cancer ... to detect breast cancer, response prediction of cancer immunotherapies and whole body, ...
Breaking Medicine Technology:
Cached News: