HOME >> MEDICINE >> NEWS
JCI table of contents, 1 August 2003

https://www.the-jci.org/press/17864.pdf


Increasing tolerance to contact allergens

Common contact allergies are triggered by allergens that affect the skin such as poison oak, poisin ivy, latex, dyes, fragrances, and metals. Researchers at the University of Mainz, Germany, have now shown that IL-10, a critical mediator of the immune response, is required in order to build-up tolerance to such allergens. The authors achieve what is known as low zone tolerance (LZT), in which repeated applications of low doses of contact allergens hinders the development of the allergic reaction. They demonstrate that mice lacking IL-10 cannot achieve LZT to allergens, suggesting that this IL-10driven response may be utilized in allergic therapies.

TITLE: Critical role of IL-10 in the induction of low zone tolerance to contact allergens

AUTHOR CONTACT:
Kerstin Steinbrink
University of Mainz, Mainz, Germany.
Phone: 49-6131-17-2297
Fax: 49-6131-17-6614
E-mail: steinbrink@hautklinik.klinik.uni-mainz.de

View the PDF of this article at: https://www.the-jci.org/press/18106.pdf


OutFoxing obesity

Obesity results from a massive expansion of fat cells. This expansion involves the differentiation of early precursor fat cells, known as preadipocytes, into mature fat cells. Researchers at Rockefeller University in New York have revealed that preadipocytes stably expressing the Foxa-2 protein do not differentiate into mature fat cells. Furthermore, in multiple rodent models of obesity they observed that Foxa-2 production is increased, in what may be an important counterregulatory mechanism to prevent the expansion of fat cell numbers. While the stimuli that induce Foxa-2 expression in mature fat cells is unknown, the authors propose that the pathways inv
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
1-Aug-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related medicine news :

1. Portable system offers dialysis patients liberating changes
2. Milk, fruits and vegetables may help reduce disability risk
3. Parents comfortable with vaccination for sexually transmitted infections for adolescent children
4. JCI table of contents, January 20 2005
5. Most adverse events in hospitalized children are preventable
6. Study finds no reduction in breast cancer risk with consumption of vegetables and fruits
7. Requip tablets treat symptoms of primary RLS
8. Medical negligence system is secretive, unaccountable and unregulated
9. Spina bifida: 70% of cases preventable by folic-acid supplementation
10. Determining which pancreatic cancers are treatable
11. Vegetable lovers should be viewed as different from fruit aficionados

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents August

(Date:10/25/2014)... New York, New York (PRWEB) October 25, 2014 ... of transvaginal mesh lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) ... multidistrict litigation underway in U.S. District Court, Southern ... Motion for Summary Judgment on Punitive Damages in ... Florida plaintiffs. In a ruling issued on October ...
(Date:10/25/2014)... 25, 2014 Limbkeepers® announced today that ... Innovations with Ed Begley Jr, airing 1st QTR 2015 ... In this episode, Innovations will focus on Limbkeepers® non ... fragile, thinning skin on arms, hands, and legs from ... these versatile products, which help reduce injuries, allow for ...
(Date:10/25/2014)... Steven Reinberg HealthDay ... The virus that causes common cold sores -- herpes simplex ... by Swedish researchers suggest. In fact, being a carrier ... of Alzheimer,s disease, the researchers found. "The identification ... dementia disorder is a breakthrough," said lead researcher Dr. Hugo ...
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Researchers ... say their findings are cause for concern. ... that are raised for human consumption contribute to ... health, according to background information from the study. ... germs sicken about 2 million people and kill ...
(Date:10/25/2014)... News) -- Current osteoporosis screening guidelines and tools ... risk for osteoporosis-related fractures, a new study says. ... need tools that help us accurately predict who ... can target these at-risk people for preventive measures," ... in the division of general internal medicine and ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2
(Date:10/22/2014)... 2014  Quest Diagnostics (NYSE: DGX ), ... announced that its Board of Directors has elected Jeffrey ... December 1, 2014. Including Dr. Leiden, the Board has ... President and CEO of Vertex Pharmaceuticals.   Dr. Leiden ... experience in the pharmaceutical and biotechnology industries as well ...
(Date:10/22/2014)... , Oct. 22, 2014  Charlene Vernak, RPh, of Vernak ... , recently was awarded the George Roentsch Scholarship by ... the award in Houston during ... is awarded annually to an independent pharmacist and PCCA ... George Roentsch , a well-known pharmacist in the ...
(Date:10/22/2014)... , Oct. 22, 2014  Paper Pak ... has developed APLS ® Body Guard Bio, ... the spread of bacteria and virus while protecting ... Body Guard Bio features a rugged, external nylon ... that create a leak-proof inner chamber that contains ...
Breaking Medicine Technology:Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 3PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2
Cached News: