HOME >> MEDICINE >> NEWS
JCI table of contents, 1 August 2003

https://www.the-jci.org/press/17864.pdf


Increasing tolerance to contact allergens

Common contact allergies are triggered by allergens that affect the skin such as poison oak, poisin ivy, latex, dyes, fragrances, and metals. Researchers at the University of Mainz, Germany, have now shown that IL-10, a critical mediator of the immune response, is required in order to build-up tolerance to such allergens. The authors achieve what is known as low zone tolerance (LZT), in which repeated applications of low doses of contact allergens hinders the development of the allergic reaction. They demonstrate that mice lacking IL-10 cannot achieve LZT to allergens, suggesting that this IL-10driven response may be utilized in allergic therapies.

TITLE: Critical role of IL-10 in the induction of low zone tolerance to contact allergens

AUTHOR CONTACT:
Kerstin Steinbrink
University of Mainz, Mainz, Germany.
Phone: 49-6131-17-2297
Fax: 49-6131-17-6614
E-mail: steinbrink@hautklinik.klinik.uni-mainz.de

View the PDF of this article at: https://www.the-jci.org/press/18106.pdf


OutFoxing obesity

Obesity results from a massive expansion of fat cells. This expansion involves the differentiation of early precursor fat cells, known as preadipocytes, into mature fat cells. Researchers at Rockefeller University in New York have revealed that preadipocytes stably expressing the Foxa-2 protein do not differentiate into mature fat cells. Furthermore, in multiple rodent models of obesity they observed that Foxa-2 production is increased, in what may be an important counterregulatory mechanism to prevent the expansion of fat cell numbers. While the stimuli that induce Foxa-2 expression in mature fat cells is unknown, the authors propose that the pathways inv
'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
1-Aug-2003


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related medicine news :

1. Portable system offers dialysis patients liberating changes
2. Milk, fruits and vegetables may help reduce disability risk
3. Parents comfortable with vaccination for sexually transmitted infections for adolescent children
4. JCI table of contents, January 20 2005
5. Most adverse events in hospitalized children are preventable
6. Study finds no reduction in breast cancer risk with consumption of vegetables and fruits
7. Requip tablets treat symptoms of primary RLS
8. Medical negligence system is secretive, unaccountable and unregulated
9. Spina bifida: 70% of cases preventable by folic-acid supplementation
10. Determining which pancreatic cancers are treatable
11. Vegetable lovers should be viewed as different from fruit aficionados

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh & Associates, ... families and business owners in North Central West Virginia, is embarking on a ... differently abled residents in the region. , The Stepping Stones organization offers a ...
(Date:6/22/2017)... ... June 22, 2017 , ... Groove Ring is excited to announce ... high performance silicon wedding bands and all-purpose rings. Whether you’re an athlete, adventurer, professional, ... designed just for you. , From the rock face to the auto shop, Groove ...
(Date:6/22/2017)... , ... June 22, 2017 , ... A June 12 ... to a correspondent concerned about an apparent lack of oral hygiene by an aged ... in geriatrics and dementia-related matters, suggests a number of steps, including scheduling a dentist ...
(Date:6/20/2017)... ... June 20, 2017 , ... After months of negotiations, FaceCradle USA is proud to announce ... Wednesday, June 21. , “Introducing our product on QVC is something we all worked hard ... travel pillow to more than 90 million homes in the United States,” said FaceCradle USA ...
(Date:6/20/2017)... ... June 20, 2017 , ... EdChoice and the American ... choice can promote economic development in economically distressed urban areas. The first report ... report, contributed to the economic development of the city of Santa Ana, California. ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... June 1, 2017 Nutriceutical Holdings (NH), parent ... Solutions (VRS), and KD Pharma Group have decided to ... by KD Pharma Group. KD Pharma Group will become ... to acquire the entire company. "We believe ... are committed to growing the NH companies by providing ...
(Date:5/29/2017)... May 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... which enables the functional selection of stem cells, today ... the first quarter ended March 31 st , 2017. ... accomplishments in the first quarter of 2017," said Dr. ... we announced the treatment of the first blood cancer ...
(Date:5/23/2017)... May 23, 2017  Leaf Healthcare, recognized for ... devices for pressure ulcer prevention, will unveil its ... of Critical Care Nurses, National Teaching Institute and ... The Leaf Patient Monitoring System is the ... hospital environment.  The system seamlessly tracks patient movement ...
Breaking Medicine Technology:
Cached News: