View the PDF of this article at: https://www.the-jci.org/press/17202.pdf
Key to blocking assembly of hepatitis delta virus highlights potential new treatment
Jeffrey Glenn and colleagues at Stanford University in California have developed a small animal model for hepatitis delta virus (HDV) which confirms that inhibitors of prenylation a vital step in virus assembly within host cells are capable of blocking this assembly and facilitating viral clearance. The study highlights their potential relevance for the treatment of chronic delta hepatitis.
In the accompanying commentary, Drs. Theo Heller and Jay Hoofnagle from the National Institutes of Health in Bethesda, Maryland, discuss the different stages of HDV replication within host cells and how this most recent finding can be used to develop suitable therapies for HDV.
TITLE: In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
Stanford University School of Medicine, Palo Alto, California, USA.
View the PDF of this article at: https://www.the-jci.org/press/17704.pdf
Denying the wolf access to sheep's clothing
Jay H. Hoofnagle
National Institutes of Health, Bethesda, Maryland, USA.
View the PDF of this commentary at: https://www.the-jci.org/press/19417.pdf