HOME >> MEDICINE >> NEWS
Jefferson Alzheimer's vaccine shows promise in animal model

"The amyloid in the brain seemed to be bound up to antibodies in the blood and cleared away," Dr. Gandy says. "We're clearly mimicking the biochemistry in the monkey that we have seen in mice. Vaccinating with amyloid brings an immune response that stimulates removal of amyloid from the body."

"The animal model described in this study expands the way we might evaluate new vaccine products," says William Thies, Ph.D., Alzheimer's Association vice president for medical and scientific affairs.

There was no evidence of inflammation in the monkey brains six months later.

According to Dr. Gandy, researchers in the late 1990s created a transgenic Alzheimer's mouse with human genes. They vaccinated the mice with beta-amyloid and found a dramatic clearing of the amyloid plaques. They also found they could prevent plaque formation if they began vaccinating before plaques formed, and could reduce plaque formation if the vaccine was given early in their development. In addition, the researchers found they could also take serum from vaccinated mice, put it in unvaccinated mice and stimulate clearance of plaques.

But in a subsequent clinical trial of 300 patients, 15 developed encephalitis, or inflammation of the brain, from an immune reaction in the brain. "The individuals developed antibodies that caused excessive brain inflammation in being drawn to the amyloid plaques and activating clearing from the brain the inflammatory response was out of control," says Dr. Gandy.

"We'd like to dissociate the good part of the immune response from the bad part," Dr. Gandy says.

Dr. Gandy notes that a cellular response by T-cells and not the antibodies could have caused the encephalitis. "It might be possible to design a different vaccine or design synthetic antibodies to avoid the encephalitis problem," he says.

Dr. Gandy and his team curre
'"/>

Contact: Steven Benowitz
steven.benowitz@jefferson.edu
215-955-6300
Thomas Jefferson University
5-Mar-2004


Page: 1 2 3

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson scientists reveal how some types of rabies invade the brain
11. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/21/2017)... ... September 21, 2017 , ... Preora ... accurate cancer screening tests, has received two prestigious recognitions that acknowledge the promise ... , Preora has been named a Top 100 Finalist for the ...
(Date:9/21/2017)... RICHMOND, Va. (PRWEB) , ... September 21, 2017 ... ... Richmond with a different approach to addiction recovery at a time when Virginia ... 1,420 deaths resulting from drug overdose, a staggering increase of 38 percent from ...
(Date:9/21/2017)... ... September 21, 2017 , ... Sagora Senior ... of Isle at Kingwood Assisted Living and Memory Care located at 24025 Kingwood ... with 55 assisted living apartments, 43 memory care apartments and 23 extended care ...
(Date:9/21/2017)... ... September 21, 2017 , ... In the inaugural ... College Emeritus Professor of Education Gregory A. Smith examines student privacy issues with ... the Switch: Schoolhouse Commercialism, Privacy, and the Failure of Policymaking . , Join ...
(Date:9/20/2017)... ... September 20, 2017 , ... FirstAlign ... (CoE) with the latest Artificial Intelligence (AI) thinking, announced today the launch of ... easy access to essential information that offers a more comprehensive understanding of the ...
Breaking Medicine News(10 mins):
(Date:9/1/2017)... , Sept. 1, 2017 Michael Penna ... Inc , highlights opportunities for growth in his response ... that Marlin Equity is seeking a buyer for eMDs. ... award-winning 22-year-old healthcare solutions Value Added Reseller and national ... "As the healthcare market continues ...
(Date:9/1/2017)... WHIPPANY, N.J. , Sept. 1, 2017  Bayer will ... at the European Society for Medical Oncology (ESMO) 2017 Congress, ... studies presented will include new preclinical and clinical data on ... from two earlier pipeline projects. ... of the best minds in cancer research at ESMO," said ...
(Date:8/29/2017)... LLC, the leading provider of continuous monitoring devices for the early ... Innovative Technology contract from Vizient, Inc., the largest member-driven health care ... ... of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ivWatch based on recommendations ...
Breaking Medicine Technology:
Cached News: