HOME >> MEDICINE >> NEWS
Jefferson Alzheimer's vaccine shows promise in animal model

"The amyloid in the brain seemed to be bound up to antibodies in the blood and cleared away," Dr. Gandy says. "We're clearly mimicking the biochemistry in the monkey that we have seen in mice. Vaccinating with amyloid brings an immune response that stimulates removal of amyloid from the body."

"The animal model described in this study expands the way we might evaluate new vaccine products," says William Thies, Ph.D., Alzheimer's Association vice president for medical and scientific affairs.

There was no evidence of inflammation in the monkey brains six months later.

According to Dr. Gandy, researchers in the late 1990s created a transgenic Alzheimer's mouse with human genes. They vaccinated the mice with beta-amyloid and found a dramatic clearing of the amyloid plaques. They also found they could prevent plaque formation if they began vaccinating before plaques formed, and could reduce plaque formation if the vaccine was given early in their development. In addition, the researchers found they could also take serum from vaccinated mice, put it in unvaccinated mice and stimulate clearance of plaques.

But in a subsequent clinical trial of 300 patients, 15 developed encephalitis, or inflammation of the brain, from an immune reaction in the brain. "The individuals developed antibodies that caused excessive brain inflammation in being drawn to the amyloid plaques and activating clearing from the brain the inflammatory response was out of control," says Dr. Gandy.

"We'd like to dissociate the good part of the immune response from the bad part," Dr. Gandy says.

Dr. Gandy notes that a cellular response by T-cells and not the antibodies could have caused the encephalitis. "It might be possible to design a different vaccine or design synthetic antibodies to avoid the encephalitis problem," he says.

Dr. Gandy and his team curre
'"/>

Contact: Steven Benowitz
steven.benowitz@jefferson.edu
215-955-6300
Thomas Jefferson University
5-Mar-2004


Page: 1 2 3

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson scientists reveal how some types of rabies invade the brain
11. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jefferson Alzheimer vaccine shows promise animal model

(Date:4/24/2015)... 2015 Anchor Health Administrators (Anchor), specialists ... today announced their exclusive agreement with LTC Solutions for ... Insurance distribution partner. , Anchor has more than 18 ... benefits for associations, and is currently the designated advocate ... Term Care Insurance member benefit. , “I am very ...
(Date:4/24/2015)... Olive Fertility Centre is proud to ... co-director, has been honoured for his pioneering work in ... Hope Gala. , “We are very pleased to ... has been at the forefront of fertility research and ... Executive Director of Fertile Futures--a Canadian non-profit organization that ...
(Date:4/24/2015)... With years of experience providing consumer ... to be partnered with a veterinary college where veterinary ... This partnership has brought new payment options for families ... providing an in-house payment plan for many years, the ... to increase financing options available to avoid having to ...
(Date:4/24/2015)... National Access Cannabis (NAC), ... to medical cannabis, is taking a leadership role in ... patients. , NAC is the first to back mdBriefCase ... grant, NAC will be providing 300 healthcare professionals with ... to help Canadians gain safe and responsible access to ...
(Date:4/24/2015)... Opera ” was featured on NewsWatch as part of its ... products available to consumers. Andrew Tropeano, a technology expert and ... viewers how this is the fastest way to surf the ... be in existence. But each web browser is slightly different ... Celebrating their 20th anniversary this year, Opera connects over 350 ...
Breaking Medicine News(10 mins):Health News:Olive Fertility Centre Co-founder, Dr Al Yuzpe, Recognized as a Pioneer in Fertility Preservation 2Health News:University of Missouri Veterinary Medical Teaching Hospital Teams with UGA 2Health News:National Access Cannabis Gives 300 Canadian Healthcare Professionals Access to Medical Cannabis Certificate Program 2Health News:A Web Browser That Connects over 350 Million People was Featured on NewsWatch Television 2
(Date:4/23/2015)... DUBLIN , April 23, 2015  Jazz Pharmaceuticals ... will report its 2015 first quarter financial results on ... financial markets.  Company management will host a live audio ... p.m. IST to discuss first quarter 2015 financial results ... Interested parties may access the live audio webcast via ...
(Date:4/23/2015)... BOULDER, Colo. , Apr. 23, 2015 /PRNewswire/ ... engineers, manufactures, and distributes state-of-the art equipment and ... specialization in commercial indoor cannabis cultivation, will host ... on Monday, April 27, 2015, at 4:15 PM ... The conference call will be listen-in ...
(Date:4/23/2015)... , April 23, 2015 Holographic Optical ... has made its Voxgram hologram technology available to ... https://www.kickstarter.com/projects/629071847/holographic-optical-technologies?ref=nav_search ... through the campaign, the eight-inch Voxbox hologram viewer. ... with its more established, medical-grade unit, the Voxbox ...
Breaking Medicine Technology:Jazz Pharmaceuticals to Report 2015 First Quarter Financial Results on May 7, 2015 2Surna, Inc. Announces Shareholder Conference Call 2Surna, Inc. Announces Shareholder Conference Call 3Holographic Optical Technologies Launches Kickstarter, Offering True 3D Holograms 2
Cached News: