HOME >> MEDICINE >> NEWS
Jefferson Alzheimer's vaccine shows promise in animal model

"The amyloid in the brain seemed to be bound up to antibodies in the blood and cleared away," Dr. Gandy says. "We're clearly mimicking the biochemistry in the monkey that we have seen in mice. Vaccinating with amyloid brings an immune response that stimulates removal of amyloid from the body."

"The animal model described in this study expands the way we might evaluate new vaccine products," says William Thies, Ph.D., Alzheimer's Association vice president for medical and scientific affairs.

There was no evidence of inflammation in the monkey brains six months later.

According to Dr. Gandy, researchers in the late 1990s created a transgenic Alzheimer's mouse with human genes. They vaccinated the mice with beta-amyloid and found a dramatic clearing of the amyloid plaques. They also found they could prevent plaque formation if they began vaccinating before plaques formed, and could reduce plaque formation if the vaccine was given early in their development. In addition, the researchers found they could also take serum from vaccinated mice, put it in unvaccinated mice and stimulate clearance of plaques.

But in a subsequent clinical trial of 300 patients, 15 developed encephalitis, or inflammation of the brain, from an immune reaction in the brain. "The individuals developed antibodies that caused excessive brain inflammation in being drawn to the amyloid plaques and activating clearing from the brain the inflammatory response was out of control," says Dr. Gandy.

"We'd like to dissociate the good part of the immune response from the bad part," Dr. Gandy says.

Dr. Gandy notes that a cellular response by T-cells and not the antibodies could have caused the encephalitis. "It might be possible to design a different vaccine or design synthetic antibodies to avoid the encephalitis problem," he says.

Dr. Gandy and his team curre
'"/>

Contact: Steven Benowitz
steven.benowitz@jefferson.edu
215-955-6300
Thomas Jefferson University
5-Mar-2004


Page: 1 2 3

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson scientists reveal how some types of rabies invade the brain
11. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jefferson Alzheimer vaccine shows promise animal model

(Date:11/28/2014)... 28, 2014 An inventor and dental assistant ... a patient’s filling and it was almost impossible to reach. ... light," she said. , The patent-pending Access Light allows for ... to areas of the mouth, as well as avoids harm ... safety. Easy to use and clean, it also helps prevent ...
(Date:11/28/2014)... Hamilton, ON Canada (PRWEB) November 28, 2014 ... labels for the stuff kids lose® and an award-winning ... Julie Cole, Julie Ellis, Cynthia Esp, and Tricia Mumby ... Entrepreneur Award. They were recognized with the PROFIT Award ... Cole, Julie Ellis, Cynthia Esp, and Tricia Mumby) accepted ...
(Date:11/28/2014)... A newly released article from Community ... influenza virus that will soon be spreading across the United ... begins with a brief explanation of what the influenza virus ... that children under the age of 5, adults over the ... as heart and lung diseases, asthma, or diabetes, are at ...
(Date:11/28/2014)... Miami, FL (PRWEB) November 28, 2014 Lice ... service areas of its in-home head lice service for ... location in the center of Coral Gables on Pone De-leon ... in Bay Harbor Islands that service Miami-Dade & Broward. ... physical salon in South Florida which has been treating families ...
(Date:11/28/2014)... 28, 2014 "Most of my life, I ... use crutches," said an inventor from Findlay, Ohio. "I thought ... to support my foot, which inspired me to invent this ... a convenient way to support an injured foot. The sling ... eliminates the need for crutches. The design redistributes weight so ...
Breaking Medicine News(10 mins):Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 2Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 3Health News:How Flu Vaccines Can Impact Families Is Discussed in New Article from Community Health Center of Snohomish County 2Health News:Lice Troopers Lice Removal Service Expands in Miami-Dade 2
(Date:11/26/2014)... November 25, 2014 According ... by Power Source (Electric, Battery, Pneumatic), by Product ... Burr, Cart), by Application (Orthopedic, ENT, Oral, Thoracic, ... MarketsandMarkets, the global Powered Surgical Instruments Market is estimated ... in 2014 and is expected to grow at ...
(Date:11/26/2014)... 2014 Reinforcing its commitment to enabling confident ... PHG AEX: PHIA) today announced 510(k) clearance ... its IQon Spectral CT , presenting an entirely ... adds a new dimension to Computed Tomography (CT) imaging, ... structures based on their material content within a single ...
(Date:11/26/2014)... --  Heska Corporation (NASDAQ: HSKA ) - ... advanced veterinary diagnostic and other specialty veterinary products , ... attend The Benchmark Company, LLC,s Micro Cap Discovery Conference on ... at The Palmer House Hilton, 17 E. Monroe Street, ... p.m. Please email hska@haydenir.com or contact your Benchmark ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3Heska to Attend Benchmark Micro Cap Discovery Conference 2
Cached News: