HOME >> MEDICINE >> NEWS
Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies

While the raccoon that raids your trash at night may look cute and mischievous, think again. Its claws can be nasty. Even worse, it might carry rabies.

Now, scientists at Jefferson Medical College in Philadelphia and at Molecular Targeting Technologies, Inc. (MTTI) in West Chester, Pa., are taking steps to prevent the disease. They have created a more powerful, safer vaccine than currently is available to combat rabies in wildlife.

Wildlife rabies is no small matter in this country. It's particularly prevalent along the East Coast, and more than 90 percent of reported cases of rabies in all are in wildlife. Raccoons are the most affected, with skunk a close second. Worldwide, and especially in underdeveloped nations, rabies takes a large human toll: More than 60,000 human deaths a year.

In work published December 9 in the journal Vaccine, researchers led by Bernhard Dietzschold, DVM, professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University, created a new live rabies vaccine by manipulating the virus itself, making it much weaker than before. The scientists also made the vaccine much more immunogenic, meaning it aroused a much more robust response from the immune system.

"The advantages of our vaccine are its lack of pathogenicity and the fact that it's much more immunogenic," he says. Live virus vaccines always carry the potential to actually cause the disease they are designed to prevent.

"We have developed a very specific rabies vaccine which displays high titers and the lack of pathogenicity for immunocompetent mice even after many passages," says Dr. Dietzschold, meaning that the vaccine retained its potency over time. "This novel rabies vaccine will be an excellent candidate for immunization of stray dogs and wildlife."

"We have found a master key to turn on and off the pathogenicity of the virus," says Chris Pak, Ph.D., MTTI president and CEO. "We are extremely pleased with these p
'"/>


8-Dec-2004


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson scientists use gene therapy to rescue failing hearts in animals
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
(Date:10/30/2014)... have to be at least 2 years old to ... no official U.S. guidance exists other than the general ... breastfeed for at least the first six months. , ... That,s the question that motivated researchers at the University ... study the eating patterns of American infants at 6 ...
(Date:10/30/2014)... 2014 Nutrition Leaders, a popular online ... aids, and more, is currently hosting a sweepstakes on ... underway, is open to U.S. residents age 18 and ... 2014. One lucky winner will then be selected at ... gift card to NutritionLeaders.com. , Nutrition Leaders’ managing director ...
(Date:10/30/2014)... Burlington, NC (PRWEB) October 30, 2014 ... life, commercial, and health insurance plans for North Carolina ... its satellite office in Burlington’s Holly Hill Mall. The ... 15, with agents already helping customers through all facets ... policy purchase. , Allred Insurance spokesman Scott Allred couldn’t ...
(Date:10/30/2014)... PreDiabetes Centers , the pioneer in prediabetes ... a supply of sugardown®, a chewable dietary supplement that ... spikes. Learning how to control blood sugar levels and ... diabetes prevention plan. , Shoppers who spend $50 or ... sugardown. The offer expires November 30. , Full-size ...
(Date:10/30/2014)... Steven Reinberg HealthDay Reporter , ... to men with prostate cancer who also have certain heart ... cause, a new study suggests. , , The therapy in question ... cancer to reduce levels of male hormones to prevent the ... the current research, this hormone therapy was linked to triple ...
Breaking Medicine News(10 mins):Health News:What do American babies eat? A lot depends on Mom's socioeconomic background 2Health News:What do American babies eat? A lot depends on Mom's socioeconomic background 3Health News:Nutrition Leaders Announces Gift Card Sweepstakes 2Health News:Allred Insurance Satellite Office Grand Opening 2Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3
(Date:10/30/2014)... 2014 The global market for human ... introduction of new vaccines. These new products and ... Market. The Kalorama information report examines the global ... developmental vaccines for diseases that are already vaccine-preventable. ... entire communities from diseases spread by person-to-person transmission. ...
(Date:10/27/2014)... , Oct. 27, 2014  RenovoRx, a leading developer ... and delivery of fluids to selected sites in the ... Directors has appointed Shaun Bagai as Chief ... RenovoRx Board of Directors. Bagai brings more than 15 ... Bagai joined RenovoRx in June 2014 and in ...
(Date:10/27/2014)... , Oct. 27, 2014  In the last few weeks, Ebola ... Africa to a worldwide crisis when a traveler ... virus and died, and two nurses were infected. While ... happen, the use of modern technology, such as electronic health records ... This week, InformationWeek Healthcare Editor Alison Diana ...
Breaking Medicine Technology:Vaccines 2014: World Market Analysis, Key Players, Trends, Pediatric and Adult Segments 2Vaccines 2014: World Market Analysis, Key Players, Trends, Pediatric and Adult Segments 3RenovoRx Board Names Shaun R. Bagai as CEO 2EHRs in the Age of Ebola: Discuss on InformationWeek 2EHRs in the Age of Ebola: Discuss on InformationWeek 3
Cached News: