Adding stereotactic radiosurgery which entails delivering radiation to specific points in the brain while sparing normal tissue after whole brain radiation therapy helps certain patients with cancer that has spread to the brain live longer, says a new study by researchers at Thomas Jefferson University Hospital in Philadelphia. In as many as one-third of all patients with lung and breast cancers, the disease spreads, or metastasizes, to the brain, leaving few good options. The disease causes neurological problems, and many patients live only about four months. Chemotherapy has been relatively ineffective in shrinking tumors and improving quality of life. Between 1996 and 2001, the Radiation Therapy Oncology Group (RTOG), a federally funded clinical trials group, led by researchers at Jefferson Medical College and elsewhere randomly assigned 333 patients to receive either the standard whole brain radiation therapy alone, or whole brain radiation therapy followed by stereotactic radiosurgery. The researchers found that patients with a single brain metastases who received radiosurgery immediately after whole brain radiation lived on average one to two months longer. Many of those had an improved quality of life after radiosurgery. Some of those with two or three brain metastases had some improvement in survival as well. "It's significant because it demonstrates for the first time a therapeutic benefit of stereotactic radiosurgery, which is a widely used technique," says first author David Andrews, M.D., professor of neurosurgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia. The researchers reported their results May 22, 2004 in the journal The Lancet.

"Our results establish a new standard of care for the treating oncologist and provide patients with realistic hope for an improved prognosis and better quality of life after treatment," Dr. Andrews says.

"This is the first non-surgical treatment to show ben
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Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
20-May-2004

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