HOME >> MEDICINE >> NEWS
Jefferson scientists create first animal model of common type of leukemia

ct this," he says. "We thought the mice would develop B-cell tumors like B-cell lymphomas, not one specific disease such as B-cell CLL." Dr. Croce and his co-workers at Fox Chase Cancer Center in Philadelphia and the Istituto Dermatopatico dell'Immacolata in Rome report their findings May 14 in the Proceedings of the National Academy of Sciences.

"We really don't know much about the genetic mechanism involved in the pathogenesis of CLL," Dr. Croce says. "What this tells us is that either the TCL-1 gene or another gene (s) in the TCL-1 pathway are involved in the initiation and maintenance of B-cell CLL. Now we can target drugs at TCL-1 or molecules that interact with TCL-1. Eventually, we'll discover other targets in the future now that we know this pathway is important."

According to Dr. Croce, because the mouse disease is nearly identical to human CLL, the model will enable scientists to investigate all of the steps involved in the development of the disease. It will also tell researchers whether - and which - drugs work best early or late in the development of the disease.

B-cell CLL is a disease of apoptosis, or programmed cell death, gone awry, he explains. Leukemia cells are not dividing or dying; instead they continue to live a very long time. The study results should "provide important clues about the regulation of programmed cell death - why leukemic cells don't die," Dr. Croce notes, "and help us understand genetic mechanisms involved."

There are as many as 10,000 new cases of B-cell CLL in the United States each year. The disease often strikes the elderly, and while incurable, is slow growing, often lasting as long as 10 to 20 years.


'"/>

Contact: Steve Benowitz
steven.benowitz@mail.tju.edu
215-955-5291
Thomas Jefferson University
21-May-2002


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson scientists reveal how some types of rabies invade the brain
11. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression

Post Your Comments:
(Date:4/16/2014)... A team that includes scientists from the School ... Center at San Antonio, Johns Hopkins University and St. ... helps a common fungus to infect the body. , ... infections, diaper rashes and oral thrush, and is the ... also cause a life-threatening infection of the blood called ...
(Date:4/15/2014)... CORVALLIS, Ore. Handling frozen fish caused nearly half ... quarter of the injuries on freezer-longliner vessels operating off ... University shows. , Many of those injuries and others ... with the right interventions, and the research methods used ... and fatalities in other types of commercial fishing, said ...
(Date:4/14/2014)... made in chemotherapy over the past decade, but targeting ... to be a major challenge. , Nanotechnology has ... use of nanocarriers, or capsules, that can transport cargoes ... , The catch? These carriers are tiny, and it ... from 10 nanometers to 100 nanometers, and the drugs ...
(Date:4/14/2014)... Penicillin, one of the scientific marvels of the 20th ... once won against bacterial infections. But scientists at the ... approach to restoring its combat effectiveness, even against so-called ... power of the penicillin family of drugs since their ... example, the staph infection, brought about by the bacterium ...
(Date:4/14/2014)... 2014 Popular web information on colorectal cancer is ... doesn,t address the appropriate risks to and concerns of ... suggests. , In a review of a dozen popular ... colorectal cancer screening were written beyond the recommended sixth-grade ... address key risks, as well as the barriers to ...
Breaking Medicine News(10 mins):Health News:Changes in processing, handling could reduce commercial fishing injuries 2Health News:Nano shake-up 2Health News:Penicillin redux: Rearming proven warriors for the 21st century 2Health News:Penicillin redux: Rearming proven warriors for the 21st century 3Health News:Website information on colon cancer too complex, fails to address key concerns 2Health News:Website information on colon cancer too complex, fails to address key concerns 3
(Date:1/15/2014)... PHILADELPHIA , Jan. 15, 2014  Echo ... a medical device company developing its Symphony® CGM ... system, today announced that Robert F. Doman ... Therapeutics, will present at "TEN", Noble Financial Capital ... Mr. Doman will make a corporate presentation to ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Worldwide Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are ... insulin delivery systems especially for type 1 ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Delivery Systems -- Focus on End Users ... STUDY OBJECTIVES A drug delivery ... aspects in today,s growth in the pharmaceutical ...
Breaking Medicine Technology:Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18
Cached News: