HOME >> MEDICINE >> NEWS
Jefferson scientists find new way to convert adult human stem cells to dopamine neurons

Researchers at Jefferson Medical College have found a new way to coax bone marrow stem cells into becoming dopamine-producing neurons. If the method proves reliable, the work may ultimately lead to new therapies for neurological diseases such as Parkinson's disease, which is marked by a loss of dopamine-making cells in the brain.

Developmental biologist Lorraine Iacovitti, Ph.D., associate director of the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia and her co-workers had previously shown that by using a potion of growth factors and other nutrients in the laboratory, they were able to convert adult human bone marrow stem cells into adult brain cells. Human adult bone marrow stem cells also known as pluripotent stem cells normally give rise to human bone, muscle, cartilage and fat cells.

While nearly all cells looked like neurons with axonal processes, they invariably reverted back to their original undifferentiated state in two to three days.

Dr. Iacovitti and her co-workers instead attempted to grow the cells in a different way. Rather than an attached monolayer of skin-like cells, they grew the bone marrow cells in suspension as neurospheres groups of cells early in development akin to the way neural stem cells are grown.

They found that the newly differentiated cells didn't merely look like dopamine neurons, but expressed traits of neurons and related cells called astrocytes and oligodendrocytes cells derived from neural stem cells. What's more, the neurons produced tyrosine hydroxylase, an enzyme needed to make dopamine.

She reports her team's findings October 25, 2004 at the annual meeting of the Society for Neuroscience in San Diego.

The Jefferson scientists also found a second enzyme involved in dopamine production, and an important molecule called the dopamine transporter.

Interestingly, Dr. Iacovitti notes, some of the cellular markers that would be expected to be expressed
'"/>


25-Oct-2004


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson scientists reveal how some types of rabies invade the brain
11. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression

Post Your Comments:
(Date:10/31/2014)... DARIEN, IL – New research suggests that insomnia is ... crashes and other unintentional fatal injuries. The results underscore ... of the National Healthy Sleep Awareness Project. , Results ... in a dose-dependent manner with the number of insomnia ... were 2.8 times more likely to die from a ...
(Date:10/31/2014)... Barbara, CA (PRWEB) October 31, 2014 ... holiday shoppers to find affordable but tasteful gifts for the ... 22nd Annual Early Bird Gift Giving Special , which ... off when they purchase Wine Club Gift membership. , ... take advantage of this special. Besides offering discounts, Gold Medal ...
(Date:10/31/2014)... Urban Hydroponics, Inc. (OTCQB:URHY), a Nevada corporation ... signed a Binding Letter of Intent (LOI) to merge ... - Urban Cultivator Inc. (“Urban Cultivator”), BC Northern Lights ... (“W3 Metal” and together with Urban Cultivator and BC ... LOI and an earlier non-binding term sheet, Urban Hydroponics, ...
(Date:10/31/2014)... New York, NY (PRWEB) October 31, 2014 ... on one of the most remarkable gifts of life ... a platform for matching extraordinary surrogate mothers and donors ... stories about individuals in unforeseen circumstances. , It’s a ... sperm donors, surrogacy agencies, surrogacy lawyers, and fertility clinics ...
(Date:10/31/2014)... Phoenix dentist , Dr. Christy, is now ... patients simply need routine care or have a more in-depth ... to get that necessary care. The right dental treatments can ... even essential treatments due to financial concerns. Throughout the month ... treatments offered by the team at Christy Dental Care. ...
Breaking Medicine News(10 mins):Health News:Insomnia increases risk of motor vehicle deaths, other fatal injuries 2Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 2Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 3Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 4Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 5Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 2Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 3Health News:Phoenix Dentist, Dr. Christy, is Now Offering Ten Percent Off On All Dental Treatments for the Month of November 2
(Date:10/31/2014)... /CNW Telbec/ - Ergoresearch Ltd ("Ergoresearch" or ... accelerated growth in terms of sales and profitability. Annual ... Net income amounted to $1,230,153. The EBITDA reached $3,087,816, ... in the Company,s history. With the goal ... of its subsidiaries, merging in September 2014 Clinique du ...
(Date:10/31/2014)... Oct. 31, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ...  What: , Isis Pharmaceuticals, Third Quarter 2014 Financial ... 7 at 11:30 a.m. ET / 8:30 a.m. PTWhere: ... the Internet. Simply log onto our website listed above. ... event, a replay of the webcast will be available ...
(Date:10/30/2014)... -- Misonix, Inc. (NASDAQ: MSON ), an international ... innovative therapeutic ultrasonic instruments for spine surgery, neurosurgery and ... financial results for the first quarter fiscal year 2015 ... a conference call that same day, Thursday, November 6, ... Interested parties can access the conference ...
Breaking Medicine Technology:Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 2Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 3Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 4Results for the fourth quarter and the fiscal year ended June 30, 2014 - Ergoresearch reports solid 2014 annual results 5Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 3Misonix, Inc. To Report First Quarter Fiscal Year 2015 Financial Results On Thursday, November 6, 2014 2
Cached News: