HOME >> MEDICINE >> NEWS
Jefferson scientists find way to see breast cancer activity from outside the body

Using precise, radioactively labeled genetic probes, researchers at Jefferson Medical College have seen cancer gene activity from outside the body in laboratory mice. The probes, which work by attaching to genetic codes copied from an active cancer gene, may someday aid physicians and scientists in cancer detection and in determining the appropriate treatment for a cancer.

"Patients might be able to avoid a great deal of worry and unneeded surgery if cancer gene activity could be detected from outside the body," says Eric Wickstrom, Ph.D., professor of biochemistry and molecular pharmacology and microbiology and immunology at Jefferson Medical College of Thomas Jefferson University in Philadelphia and at Jefferson's Kimmel Cancer Center.

The scientists would like to detect cancerous breast tumors as early as possible, particularly before they begin to spread to other areas of the body. "We want to detect them before mammograms can find them," Dr. Wickstrom says. "We want to see whether a cancer gene is active, which will tell clinicians the best way to treat it, according to the cancer gene activity of the tumor. If we can see the hotspot of cancer gene activity before the tumor has formed, we can start to treat earlier." The researchers report their results in December in the Journal of Nuclear Medicine.

The gene, called cyclin D1, is turned on in the majority of breast cancers, he explains. The genetic probe, which is a DNA derivative, carries an attached radioactive label, and binds to cyclin D1 messenger RNA (mRNA). The latter is involved in translating DNA instructions and making proteins.

Dr. Wickstrom, Mathew Thakur, Ph.D., professor of radiology at Jefferson Medical College and their co-workers contend that the strategy using genetic probes to visualize sites of cancer gene activity can work for detecting the activity of other cancer genes in various types of tumors.

"The radioactive probes can help us identify the cancer cell
'"/>


9-Dec-2004


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
8. Jefferson scientists use gene therapy to rescue failing hearts in animals
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, ... administering Medicare Advantage and Special Needs plans, is proud to support the 2020 ... Plans (AHIP). RAM is supporting the event as a sponsor and exhibitor and ...
(Date:9/1/2020)... Fla. (PRWEB) , ... September 01, 2020 , ... ... Reconstructive Surgeon with specialty fellowship training in aesthetic surgery of the face, breast, ... MD – the only female-owned premier boutique plastic surgery and aesthetic practice in ...
(Date:8/31/2020)... ... 31, 2020 , ... Want to get moving, break up your routine, and ... is thrilled to launch its fourth annual STEPtember campaign in the United States to ... everyone wherever they are at this moment — encouraging people to move in the ...
(Date:8/31/2020)... Hawaii (PRWEB) , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with ... people on the planet are in a state of panic, experiencing deep anxiety, immense stress, ... Right now, a solution is timely when most people on the planet are experiencing a ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst ... Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now ... leaders whose ambitions deliver innovation, growth and prosperity as they build and sustain ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the ... apnea patient, is the company’s new spokesperson. , “In my line of work, a ... I found the Bleep DreamPort it was a Bleeping no brainer for me,” said ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bridge To A Cure Foundation announces the appointment ... and pediatric neuro-oncologist who serves on the Board of Directors at The Preston Robert ... Medical School. , Internationally recognized, Dr. Friedman is a widely published author of more ...
(Date:8/26/2020)... ... August 26, 2020 , ... ScripHessco has announced ... The infographic breaks down ways that chiropractors can help heal sports injuries and ... ScripHessco “Athletes have an unusual amount of pressure and stress on their bodies, ...
Breaking Medicine Technology:
Cached News: