HOME >> MEDICINE >> NEWS
Jefferson scientists help explain statins' effects in Alzheimer's disease

Scientists at Jefferson Medical College and the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia have taken another step in understanding the potential effects of anti-cholesterol drugs on Alzheimer's disease. They have identified a biochemical pathway that explains the activity of statins, particularly their ability to break down an early form of the protein amyloid that clusters and forms sticky plaques in the Alzheimer's brain.

The results may eventually help provide new targets for anti-amyloid drugs to help treat Alzheimer's disease. They report their findings Jan. 11, 2005 in the online journal the Public Library of Science Medicine.

Some epidemiological studies have found a link between people taking statin drugs to lower blood cholesterol and a lower incidence of Alzheimer's. Statins work by inhibiting an enzyme involved in cholesterol production, and currently is being tested in clinical trials for their possible effects in slowing the progression of Alzheimer's.

In a series of experiments, Sam Gandy, M.D., Ph.D., director of the Farber Institute for Neurosciences at Jefferson, Steve Pedrini, Ph.D., a postdoctoral fellow in Neurology in Jefferson Medical College of Thomas Jefferson University and in the Farber Institute for Neurosciences and their co-workers found evidence suggesting that an enzymatic pathway called Rho/ROCK may play an important role in the metabolism of APP (amyloid-beta peptide precursor protein), which is an early form of amyloid, and in turn, the ability of statins to break down a form of APP.

According to Dr. Gandy, APP can be broken down in two ways: "Bad cleavage" releases toxic amyloid-beta; "good cleavage" destroys it. Evidence shows that when the pathway ROCK1 is active, less good cleavage occurs. Statins, however, reduce ROCK1 activity, making it more likely that good cleavage will be in effect.

"It's particularly important to understand the pathways
'"/>


10-Jan-2005


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists find zinc may help prevent esophageal, oral cancers
5. Jefferson virologists coax HIV out of hiding
6. Jefferson scientists find way to see breast cancer activity from outside the body
7. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
8. Jefferson scientists use gene therapy to rescue failing hearts in animals
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
(Date:7/28/2015)... ... 2015 , ... BiologicsMD, Inc. , a privately held ... of bone disorders and conditions of hair loss, announced that the U.S. Patent ... Binding-Domain and Parathyroid Hormone". The issued patent claims methods of use for promoting ...
(Date:7/28/2015)... ... July 28, 2015 , ... ... include a proprietary, web based clinical knowledge system, called “Referral Guidance.” ... It provides physicians who are anticipating making a subspecialty referral an efficient ...
(Date:7/28/2015)... ... July 28, 2015 , ... Every summer, the public is reminded to leave ... lighting fireworks in their own neighborhoods. Unfortunately, according to a recent report issued by ... USA Today article " Eye Injuries Caused by Fireworks Doubled in Last 3 Years ...
(Date:7/28/2015)... CA (PRWEB) , ... July 28, 2015 , ... ... of Acute Coronary Syndromes (ACS-Heart Attack, Sudden Death, or Angina), many of whom ... cardiology is the identification of individuals with active yet undetected sub-clinical disease, who ...
(Date:7/28/2015)... ... July 28, 2015 , ... There has been much discussion in ... bridges and railroads, often overlooked is the over 740,000 miles of municipal sewer ... into sewage treatment facilities. According to the American Society of Civil Engineers , ...
Breaking Medicine News(10 mins):Health News:BiologicsMD, Inc. Announces Additional US Patent Issuance Covering Company’s Pipeline of Targeted Therapies 2Health News:Introducing Care to Care’s New Web Based “Referral Guidance” Program 2Health News:Carlsbad Ophthalmologist Discusses Doubling of Fireworks Eye Injuries in Three Year Span 2Health News:Carlsbad Ophthalmologist Discusses Doubling of Fireworks Eye Injuries in Three Year Span 3Health News:Utility of a novel coronary artery disease biomarker algorithm in modifying physician adherence to guideline therapy presented at 20th World Congress on Heart Disease 2Health News:With an Infrastructure Spending Bill on the Horizon, RestorationEze Discusses the Impact an Aging Sewer System is Having on Homeowners 2Health News:With an Infrastructure Spending Bill on the Horizon, RestorationEze Discusses the Impact an Aging Sewer System is Having on Homeowners 3
(Date:7/28/2015)...  Today, Sekisui Diagnostics announces the launch of the ... with a broad menu of high quality SEKURE reagents, ... office or hospital laboratory. The SK500 ... ISE, 72 patient sample on-board capability, minimizes the use ... ISE) to meet the testing needs of small-to-moderate volume ...
(Date:7/28/2015)... Voalte, the leader in healthcare communication ... wireless communications, today announced that Bay Area Regional ... facility in Webster, Texas , ... on Spectralink PIVOT™ purpose-built smartphones for caregiver communication.  ... member of its AIMS Partner Program last fall, ...
(Date:7/28/2015)... 28, 2015 Egalet Corporation (Nasdaq: ... company focused on developing, manufacturing and marketing innovative ... underwritten public offering of 6,666,667 shares of its ... $11.25 per share. The gross proceeds to Egalet ... $75 million, before deducting the underwriting discounts and ...
Breaking Medicine Technology:Sekisui Diagnostics Announces Launch of SK500 Clinical Chemistry System for US Laboratories 2Bay Area Regional Medical Center Is First to Use Spectralink PIVOT with Voalte One for Caregiver Communication 2Bay Area Regional Medical Center Is First to Use Spectralink PIVOT with Voalte One for Caregiver Communication 3Egalet Announces Pricing of Public Offering of Common Stock 2Egalet Announces Pricing of Public Offering of Common Stock 3Egalet Announces Pricing of Public Offering of Common Stock 4
Cached News: