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Jefferson scientists help explain statins' effects in Alzheimer's disease

involved in Alzheimer's, especially to find more specific therapies," Dr. Pedrini says.

"This reveals an unsuspected pathway linking statins and amyloid metabolism," says Dr. Gandy. "This may help unravel statin action in Alzheimer's as well as point the way toward novel anti-amyloid drugs."

Dr. Gandy notes that the work is part of a developing anti-amyloid cocktail that may involve using several drugs, each aimed at a different target, not unlike chemotherapy for cancer. A drug called Alzhemed, for example, which currently is in clinical trials at Jefferson's Farber Institute for Neurosciences, breaks up amyloid aggregates. Vaccines stimulate the immune system to break down amyloid. Statins are yet another strategy.


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10-Jan-2005


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