HOME >> MEDICINE >> NEWS
Jefferson scientists reveal how some types of rabies invade the brain

Virologists at Jefferson Medical College have found that certain elements of bat rabies virus genes make the virus more adept at invading the brain.

Bat rabies is an emerging problem in North America. It's different from other rabies viruses: It seems able to reach the brain much more quickly than other strains of rabies, and it takes less virus to initiate the brain infection. In many cases of bat rabies infection, there is no known route of exposure.

The researchers, led by Bernhard Dietzschold, DVM, professor of microbiology and immunology and Matthias Schnell, Ph.D., associate professor and acting chair of biochemistry and molecular pharmacology, both at Jefferson Medical College of Thomas Jefferson University in Philadelphia, analyzed which rabies virus genes from a silver-haired bat might play a role in the virus's ability to infect the brain. To do so, they built the first molecular clone of a rabies "street" virus, akin to the virus found in the wild. They then exchanged the genes of the silver-haired bat rabies virus clone with those of a strain used in a rabies wildlife vaccine and discovered that certain parts particularly the glycoprotein cover on the virus surface are responsible for the virus's superior ability to attack the brain. They reported their findings this month online in the Proceedings of the National Academy of Sciences.

According to Dr. Dietzschold, the glycoprotein is involved in the uptake of virus by the cell receptor. He notes that the uptake of the silver-haired bat rabies virus is five times faster than other types of rabies virus from other species, which, he says, might account for its ability to infect the brain so rapidly. They reported their findings online in November in the Proceedings of the National Academy of Sciences.

"We also found that the expression of viral genes and proteins the replication of the virus is extremely regulated," he says, which differs from other species. "The virus ev
'"/>


14-Nov-2004


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, ... administering Medicare Advantage and Special Needs plans, is proud to support the 2020 ... Plans (AHIP). RAM is supporting the event as a sponsor and exhibitor and ...
(Date:9/1/2020)... Fla. (PRWEB) , ... September 01, 2020 , ... ... Reconstructive Surgeon with specialty fellowship training in aesthetic surgery of the face, breast, ... MD – the only female-owned premier boutique plastic surgery and aesthetic practice in ...
(Date:8/31/2020)... ... 31, 2020 , ... Want to get moving, break up your routine, and ... is thrilled to launch its fourth annual STEPtember campaign in the United States to ... everyone wherever they are at this moment — encouraging people to move in the ...
(Date:8/31/2020)... Hawaii (PRWEB) , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with ... people on the planet are in a state of panic, experiencing deep anxiety, immense stress, ... Right now, a solution is timely when most people on the planet are experiencing a ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst ... Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now ... leaders whose ambitions deliver innovation, growth and prosperity as they build and sustain ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the ... apnea patient, is the company’s new spokesperson. , “In my line of work, a ... I found the Bleep DreamPort it was a Bleeping no brainer for me,” said ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bridge To A Cure Foundation announces the appointment ... and pediatric neuro-oncologist who serves on the Board of Directors at The Preston Robert ... Medical School. , Internationally recognized, Dr. Friedman is a widely published author of more ...
(Date:8/26/2020)... ... August 26, 2020 , ... ScripHessco has announced ... The infographic breaks down ways that chiropractors can help heal sports injuries and ... ScripHessco “Athletes have an unusual amount of pressure and stress on their bodies, ...
Breaking Medicine Technology:
Cached News: