HOME >> MEDICINE >> NEWS
Jefferson scientists uncover potential trigger of diabetic kidney disease

Scientists at Jefferson Medical College and Mount Sinai School of Medicine have identified a protein that plays a leading part in triggering kidney disease in diabetic patients, a condition known as diabetic nephropathy and the leading cause of kidney failure worldwide. The finding, which they report February 22 in the journal PLoS Medicine, could lead to the eventual development of compounds that might be used to treat diabetic kidney disease.

According to study co-author Kumar Sharma, M.D., director of the Center for Diabetic Kidney Disease at Thomas Jefferson University in Philadelphia and professor of medicine at Jefferson Medical College of Thomas Jefferson University, more than 40 percent of patients with end-stage chronic kidney disease also have diabetic nephropathy. While diabetic nephropathy affects approximately one in three people with type 1 and type 2 diabetes, how diabetes damages the kidneys is poorly understood.

Dr. Sharma, along with Erwin Bttinger, M.D., professor of medicine and pharmacology and biological chemistry at Mount Sinai School of Medicine in New York, and their co-workers looked at kidney samples from mice and people with and without diabetes and looked at the effects of high glucose on the kidney cells.

The researchers found that a protein called CD36 was present in a specific cell type called the proximal tubular epithelial cell in human diabetic kidney disease. In humans, the cells seem to be involved in a self-directed cell death or apoptosis in diabetic kidney disease.

"We think CD36 might be a switch that is turned on in the human condition, and might be one of the reasons these cells die in human disease and start a cascade of progressive kidney failure," Dr. Sharma explains. "If we can develop compounds to block CD36, it could potentially be a clinical intervention. "Our thinking is completely novel that CD36 is a key player in causing progressive diabetic kidney disease," he says. "W
'"/>


21-Feb-2005


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
3. Jefferson scientists help explain statins effects in Alzheimers disease
4. Jefferson scientists find zinc may help prevent esophageal, oral cancers
5. Jefferson virologists coax HIV out of hiding
6. Jefferson scientists find way to see breast cancer activity from outside the body
7. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
8. Jefferson scientists use gene therapy to rescue failing hearts in animals
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... ... 2020 , ... The Society to Improve Diagnosis in Medicine ... University of Massachusetts Medical School- Baystate and Ann Gaffey, RN, MSN, CPHRM, DFASHRM, ... Directors. Dr. Salvador and Ms. Gaffey’s service began in May and the initial ...
(Date:6/28/2020)... ... June 26, 2020 , ... Medisend College of ... intensive education and training that prepares graduates for professional careers as field service ... the Board of Trustees. , Ms. Williams currently serves as Associate Vice Chancellor ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Coronavirus pandemic created shortages ... a supplier of top-quality masks, sanitizers and thermometers, Trusted PPE is a woman ... Agarwal observed, “All of our masks are manufactured to medical standards in FDA-certified ...
(Date:6/28/2020)... ... June 28, 2020 , ... ... the world, dedicates World Allergy Week, from June 28 to July 4, 2020, ... SARS CoV-2. , COVID-19, short for “coronavirus disease 2019”, is a disease spreading ...
(Date:6/24/2020)... ... June 24, 2020 , ... Evolved Naturals, a new brand of ... at http://www.evolvednaturals.com The newly launched website showcases a variety of health ... and a comprehensive line of skincare & topical products . , Doug ...
Breaking Medicine News(10 mins):
(Date:6/23/2020)... ... June 23, 2020 , ... Lighthouse ... Applied Behavioral Analysis ("ABA") therapy, today announced the acquisition of Autism Therapy ... This acquisition will make Lighthouse Autism Center one of the largest ABA ...
(Date:6/23/2020)... ... June 23, 2020 , ... Award-winning digital product design and ... over 60 million users, to build a COVID-19 map . The goal between ... date clarity through easy-to-understand data and visuals on the current COVID-19 situation both globally ...
(Date:6/19/2020)... Ariz. (PRWEB) , ... June 19, 2020 , ... With ... soon launch another Warrior Gym at in Queen Creek. Since the foundation of the ... complete freedom. In essence, all of the gym locations still share the vision of ...
Breaking Medicine Technology:
Cached News: