HOME >> MEDICINE >> NEWS
Jefferson scientists uncover potential trigger of diabetic kidney disease

Scientists at Jefferson Medical College and Mount Sinai School of Medicine have identified a protein that plays a leading part in triggering kidney disease in diabetic patients, a condition known as diabetic nephropathy and the leading cause of kidney failure worldwide. The finding, which they report February 22 in the journal PLoS Medicine, could lead to the eventual development of compounds that might be used to treat diabetic kidney disease.

According to study co-author Kumar Sharma, M.D., director of the Center for Diabetic Kidney Disease at Thomas Jefferson University in Philadelphia and professor of medicine at Jefferson Medical College of Thomas Jefferson University, more than 40 percent of patients with end-stage chronic kidney disease also have diabetic nephropathy. While diabetic nephropathy affects approximately one in three people with type 1 and type 2 diabetes, how diabetes damages the kidneys is poorly understood.

Dr. Sharma, along with Erwin Bttinger, M.D., professor of medicine and pharmacology and biological chemistry at Mount Sinai School of Medicine in New York, and their co-workers looked at kidney samples from mice and people with and without diabetes and looked at the effects of high glucose on the kidney cells.

The researchers found that a protein called CD36 was present in a specific cell type called the proximal tubular epithelial cell in human diabetic kidney disease. In humans, the cells seem to be involved in a self-directed cell death or apoptosis in diabetic kidney disease.

"We think CD36 might be a switch that is turned on in the human condition, and might be one of the reasons these cells die in human disease and start a cascade of progressive kidney failure," Dr. Sharma explains. "If we can develop compounds to block CD36, it could potentially be a clinical intervention. "Our thinking is completely novel that CD36 is a key player in causing progressive diabetic kidney disease," he says. "W
'"/>


21-Feb-2005


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
3. Jefferson scientists help explain statins effects in Alzheimers disease
4. Jefferson scientists find zinc may help prevent esophageal, oral cancers
5. Jefferson virologists coax HIV out of hiding
6. Jefferson scientists find way to see breast cancer activity from outside the body
7. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
8. Jefferson scientists use gene therapy to rescue failing hearts in animals
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... , ... February 13, 2019 , ... ... 2019, at the company’s annual member conference, Elevate 2019 at the Gaylord Rockies ... staff and members to explore potential partnerships driving improved quality of patient care, ...
(Date:2/13/2019)... ... February 13, 2019 , ... American Vision Partners, ... the nation, announced a new addition to their growing list of ophthalmology brands: ... within a multi-specialty ophthalmology practice. , Dr. Zachary Berbos, MD, FACS, ...
(Date:2/13/2019)... ... February 13, 2019 , ... Asana Recovery is accepting ... students who choose to pursue a medical-related course of study in California, the $1,000 ... substance abuse disorder and mental health treatment, and how it has led them to ...
(Date:2/12/2019)... ... February 12, 2019 , ... Medical Device Risk ... Ombu Enterprises**, Feb. 19-20, 2019, Atlanta, GA , https://www.fdanews.com/mdriskmanagement , One ... of Change on Jan. 22 , Risk management is just plain hard, complicated, ...
(Date:2/11/2019)... ... February 11, 2019 , ... Caring Health Systems ... integrated suite could more effectively manage its complex environment of 1,100+ employees across ... client, Caring Health chose SmartLinx to automate its changing staffing needs, such as ...
Breaking Medicine News(10 mins):
(Date:2/13/2019)... ... February 13, 2019 , ... The Medicus Firm (TMF) ... Physician Recruiters (ASPR). “The Medicus Firm has been a vocal and enthusiastic supporter ... stewardship and support of educational programs are part of our DNA and becoming a ...
(Date:2/13/2019)... , ... February 13, 2019 , ... Co-founded in a ... aims to give women an empowering place to not only exercise, but to nurture ... CEO Devan is a former professional baseball player with the San Francisco Giants and ...
(Date:2/13/2019)... & ORLANDO, Fla. (PRWEB) , ... February 13, ... ... platform for voice and chatbot applications in healthcare, today announced through its collaboration ... two additional platforms: Google Assistant and voice-powered web chat. This takes Mayo ...
Breaking Medicine Technology:
Cached News: