HOME >> MEDICINE >> NEWS
Jefferson scientists use gene therapy to rescue failing hearts in animals

Heart researchers at Jefferson Medical College have used gene therapy to bring failing rat hearts back to normal.

Scientists led by Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine in Jefferson Medical College of Thomas Jefferson University in Philadelphia, used a virus to insert the gene for a protein called S100A1 into failing rat hearts. "In contrast to other gene therapy strategies geared to overexpressing a gene," says Dr. Koch, who is W.W. Smith Professor of Medicine at Jefferson Medical College, "because this protein is reduced in heart failure, simply bringing the protein level back to normal restored heart function." Dr. Koch and his co-workers report their findings December 1, 2004 in the Journal of Clinical Investigation.

S100A1, which is part of a larger family of proteins called S100, binds to calcium and is primarily found at high levels in muscle, particularly the heart. Previous studies by other researchers showed that the protein was reduced by as much as 50 percent in patients with heart failure. A few years ago, Dr. Koch and his co-workers put the human gene that makes S100A1 into a mouse, and found a resulting increase in contractile function of the heart cell. The mice hearts worked better and had stronger beats.

Dr. Koch's Jefferson team now examined whether it could make failing hearts normal again. The researchers 12 weeks after they simulated a heart attack in the rats delivered the human S100A1 gene to the heart through the coronary arteries by injection of a genetically-modified common cold virus as a carrier. After about a week, they found the hearts began to work normally. In addition, the animals' heart muscle showed improved efficiency in using its energy supply, which was decreased in heart failure. According to Dr. Koch, the improvements were seen in both the whole animal as well as in individual heart cells.

"This
'"/>


1-Dec-2004


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2020)... Conn. (PRWEB) , ... February 19, 2020 , ... ... periodontists at Advanced Periodontics and Dental Implant Center of Connecticut, celebrate 30 years ... new patients with the same low fees that they charged in 1989, only ...
(Date:2/19/2020)... ... 19, 2020 , ... Actor, director, and producer, Laurence Fishburne ... his acting abilities demonstrated in blockbuster hits like the “John Wick” series, Fishburne ... Laurence Fishburne. “Behind The Scenes” features a broad array of topics. A new ...
(Date:2/19/2020)... ... February 19, 2020 , ... In 2017, the ... regulations and requirements that currently govern medical device manufacturers under the Medical Devices ... 25 May 2020. Major changes from the previous MDD include:, ...
(Date:2/19/2020)... ... 2020 , ... Nvision Biomedical Technologies , a San ... lower extremities at the American College of Foot and Ankle Surgeons Annual Scientific ... Stand-Alone Osteotomy Wedge Fixation System will lead Nvision's innovative showcase. The Trigon titanium ...
(Date:2/19/2020)... ... 2020 , ... SafiraMD Medical Aesthetics & Wellness Center is ... most popular non-invasive fat reduction treatment. Their CoolEvent will be held on March ... Alpharetta, Georgia. The CoolEvent will feature live demonstrations, exclusive discounts, giveaways and much ...
Breaking Medicine News(10 mins):
(Date:2/21/2020)... ... February 21, 2020 , ... The business of healthcare management ... up with industry trends and ensuring patients digital and physical safety, there are many ... , That’s why MaintenX International’s is excited to provide their insights on healthcare ...
(Date:2/20/2020)... ... February 20, 2020 , ... Amada Senior Care of Long ... care from trained and knowledgeable Amada caregivers. From day one of opening, owners ... client’s unique needs, preferences and desires, all with the goal of delivering the ...
(Date:2/20/2020)... (PRWEB) , ... February 20, 2020 , ... ... on addressing unmet needs in the field of urology, today announced that Jayant ... Center of Excellence. The designation recognizes that Dr. Uberoi has achieved a high ...
Breaking Medicine Technology:
Cached News: