HOME >> MEDICINE >> NEWS
Jefferson scientists use gene therapy to restore function of damaged heart cells in laboratory

Researchers at Jefferson Medical College and Duke University have used gene therapy to help damaged heart cells regain strength and beat normally again in the laboratory. The work takes the scientists one step closer to eventual clinical trials in humans.

Walter Koch, Ph.D., director of the Center for Translational Medicine of the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his colleagues at Duke used a virus to carry a gene into the heart cells of individuals who had suffered heart failure. The gene blocks the activity of an enzyme that is increased in such heart cells, in turn, enabling the cells to beat at normal strength. Dr. Koch and his co-workers at Duke University Medical Center in Durham, N.C., presented their findings this week at the American Heart Association's Scientific Sessions 2003 in Orlando.

According to Dr. Koch, who is W.W. Smith Professor of Cardiology at Jefferson Medical College of Thomas Jefferson University, researchers have known for some time that the beta-adrenergic receptor system fails to work properly in individuals with end-stage heart failure. Such receptors "drive the heart both by rate and force of contraction," he says.

The researchers' target has been the beta-adrenergic kinase (ARK1), an enzyme that is elevated in human heart failure. One of its functions is to turn off beta-adrenergic receptors. "In heart failure, beta adrenergic receptor density is decreased, ARK is increased and both together cause dysfunctional beta receptor signaling," Dr. Koch says. "A failing heart then has little capacity to respond to exercise or stress because there are fewer receptors and the remaining receptors are more or less turned off.

"We have thought that inhibiting ARK could increase signaling and increase function," he explains.

In the laboratory dish, the researchers infected heart cells from patients who underwent cardiac transplantation due to end
'"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
13-Nov-2003


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson virologists coax HIV out of hiding
7. Jefferson scientists find way to see breast cancer activity from outside the body
8. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
9. Jefferson scientists use gene therapy to rescue failing hearts in animals
10. Jefferson scientists reveal how some types of rabies invade the brain
11. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... , ... September 03, 2020 , ... ... memory impairment, has announced the Best Memory Care Facilities in Louisville, KY. The ... features and amenities. , According to the Alzheimer’s Association , 5.6 ...
(Date:9/1/2020)... ... ... Feeding Matters , the first organization in the world dedicated to advancing the ... that the U.S. Centers for Disease Control and Prevention (CDC) has officially approved PFD ... U.S. International Classification of Diseases (ICD ) on October 1, 2021. ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Just found out your dear friend has ... heartbreaking when your friend or family member shares their diagnosis. Once the shock wears off, ... say the wrong thing? What are the best ways to help? Words are failing me. ...
(Date:8/31/2020)... ... 31, 2020 , ... Smile Brands Inc., one of the ... States, today announced the grand opening of another affiliated Bright Now! Dental ... convenient hours, a comfortable office, and full-service care at the new Beaumont location. ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... intended to improve outcomes for patients with advanced heart failure, today announced that ... grant in the amount of $555,358 from the National Heart, Lung, and Blood ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... , ... September 02, 2020 , ... ... Raman technology, will moderate a roundtable discussion among industry professionals about successes and ... be hosted by American Pharmaceutical Review and will take place on ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... host the Agilent Science and Technology Virtual Symposium 2020 (ASTVS 2020) ... will open a suite of Live webinars and Networking sessions, with a vast ...
(Date:9/1/2020)... (PRWEB) , ... September 01, 2020 , ... While coronavirus ... alarming rate as businesses, schools and community organizations remain closed. Because about 80% of ... needs the help of both blood donors and blood drive hosts to ensure blood ...
Breaking Medicine Technology:
Cached News: