HOME >> MEDICINE >> NEWS
Jefferson virologists coax HIV out of hiding

When researchers came up with the powerful cocktail of anti-HIV drugs known as highly active antiretroviral therapy (HAART), they hoped they had found a way to finally rid the body of the virus. But they were wrong. The virus instead goes into hiding, dormant and practically undetectable in the body and impervious to attack. While HAART manages to keep the virus at bay, it's still quite capable given the right opportunity of replicating and wreaking havoc on the body's immune system.

Now, virologists at Jefferson Medical College, led by Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and director of the Division of Infectious Diseases and Environmental Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, may have found a way to bring HIV out of hiding. They have shown that an immune cell protein called interleukin-7 (IL-7) can rouse the virus better than previously tried agents, making it vulnerable to drugs and the body's immune system. If the new technique proves its mettle, the work could lead to improved treatments for HIV infection, and might be a step toward complete viral eradication.

The Jefferson team reports its findings January 4, 2005 in the Journal of Clinical Investigation.

Dr. Pomerantz, who is director of Jefferson's Center for Human Virology and Biodefense, and his co-workers took blood cells from HIV-infected patients who had been taking HAART and who had undetectable levels of virus. Using a special technique, they screened the cells with several different drugs to determine what stimulated the latent virus the best.

"To our surprise, it was IL-7," he says. "We don't know why, but it is the best agent in terms of its ability to stimulate HIV out of latency that we've seen in the last 15 years." They found that the virus was stimulated to higher levels and was activated in more patients than with other compounds.

Dr.
'"/>


3-Jan-2005


Page: 1 2

Related medicine news :

1. Jefferson Lab medical imager spots breast cancer
2. Jefferson scientists uncover potential trigger of diabetic kidney disease
3. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
4. Jefferson scientists help explain statins effects in Alzheimers disease
5. Jefferson scientists find zinc may help prevent esophageal, oral cancers
6. Jefferson scientists find way to see breast cancer activity from outside the body
7. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
8. Jefferson scientists use gene therapy to rescue failing hearts in animals
9. Jefferson scientists reveal how some types of rabies invade the brain
10. Jefferson neuroscientists studying new type of Alzheimers drug to halt disease progression
11. Jefferson scientists uncover new evidence to help explain statins effects in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... 2020 , ... Representatives with Bay-Bay Water today announced that the company has launched ... company logo as part of the ongoing evolution of our company’s brand,” said Osmay Gonzalez, ... company is expanding its national reach. , “We have refreshed our logo to reflect who ...
(Date:2/20/2020)... ... , ... R3 Medical Training announced its next joint injection training courses scheduled ... injections for all large and small joints along with ultrasound needle guidance. , Performing ... opportunity is to perform injections in a supervised setting. R3 Medical Training's joint ...
(Date:2/19/2020)... MONROE, Conn. (PRWEB) , ... February 19, 2020 ... ... respected periodontists at Advanced Periodontics and Dental Implant Center of Connecticut, celebrate 30 ... all new patients with the same low fees that they charged in 1989, ...
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... ... quality and consistency of healthcare delivery, announced that it will participate in the ... in Orlando, Florida. BPM+ Health will engage healthcare professionals and other stakeholders at ...
(Date:2/16/2020)... ... 2020 , ... Canadian digital healthcare portal Ask The Doctor has ... about the Coronavirus. , "It is our duty and it is our responsibility to ... said Prakash Chand, CEO of Ask The Doctor. , Doctors and nurses around the ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... 2020 , ... NeoTract, a wholly owned subsidiary of Teleflex ... announced that Jayant Uberoi, MD, Chesapeake Urology in Baltimore MD, has been designated ... achieved a high level of training and experience with the UroLift® System and ...
(Date:2/19/2020)... ... February 19, 2020 , ... Aspire Regenerative, a leader ... with Cortex Wellness Pharmacy for a free weight-loss event on March 1, 2020. It ... Ave., #100, La Jolla, CA, 92037. , During the event, physicians and pharmacists will ...
(Date:2/19/2020)... ... February 19, 2020 , ... The Team Type 1 Foundation, ... medicine for everyone affected by diabetes, announced a partnership with VeloCity, a fundraising ride ... third annual VeloCity event takes place on May 2nd and begins on the Mercedes-Benz ...
Breaking Medicine Technology:
Cached News: