HOME >> MEDICINE >> NEWS
Key immune system protein reduced in HIV-associated dementia patients

Researchers at the San Francisco Veterans Affairs Medical Center and UCSF have discovered that an important protein normally secreted by macrophages, the scavenger cells of the immune system, is secreted at significantly reduced levels in patients with HIV-related dementia.

The protein, known as lysozyme, is an anti-viral, anti-bacterial enzyme found in human monocytes (which differentiate into macrophages), which circulate in the blood stream but migrate as macrophages to the brain and other organs to fight infection.

Monocyte/macrophages are known to become infected by HIV in the bloodstream, but unlike the immune system's T-cells, they are not killed when infected. (The virus continues to infect the macrophages even in the presence of highly active antiretroviral therapy (HAART).) Instead, the cells serve as a reservoir for the virus. As the cells sometimes migrate to the brain, they can give the virus access to the organ early in the infection.

The discovery that HIV-infected macrophages secrete lysozyme at dramatically reduced levels in HIV-demented patients suggests that the macrophages are no longer highly activated, but are, instead, dysfunctional and thus unable to fight HIV-1 or other infections, says lead researcher Lynn Pulliam, PhD, associate chief of staff for research at the SF Veterans Affairs Medical Center and UCSF professor of laboratory medicine and medicine.

In earlier studies, the researchers have shown that certain immune-system molecules secreted by HIV-infected monocyte/macrophages are toxic to the brain's neurons, or nerve cells. The new study identifies for the first time, says Pulliam, a specific protein in HIV-infected macrophages that is not secreted in patients with HIV-dementia.

It's possible, she says, that the protein could prove to be a marker to monitor the progression of HIV-associated dementia and serve as a possible target for treatment.

In their study, the researchers investigate
'"/>

Contact: Joan Aragone
jaragone@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-May-2004


Page: 1 2

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
3. Smart immune cells kill more cancer
4. New network of gastrointestinal immune cells discovered
5. Old T cells cripple immune function in the elderly
6. Novel p53 gene-based therapy boosts immune system and reduces tumor size
7. VGTI researchers help uncover why aging reduces immune system function
8. Brains immune system triggered in autism
9. Marine sponge leads researchers to immune system regulator
10. Mayo Clinic discovers one mechanism for why men and women differ in immune response
11. Longterm immune memory cells cells do not develop during chronic viral infections

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Frederick area economy by obtaining investment capital for emerging technology companies. ... years that have already resulted in more than a million dollars of capital ...
(Date:6/24/2016)... ... June 24, 2016 , ... Finally, a bruise cream that really works. ... be incorporated into the post-surgical treatment plans of a variety of other procedures including, ... is very effective for bruising and causes a rapid resolution of bruising and inflammatory ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Dr. Seema ... joins Evans Dermatology in the South Lamar location as of July 13, 2016. , ... Medical School. As a medical student, she regularly volunteered at the Agape Clinic serving ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology:
Cached News: