HOME >> MEDICINE >> NEWS
Key immune system protein reduced in HIV-associated dementia patients

Researchers at the San Francisco Veterans Affairs Medical Center and UCSF have discovered that an important protein normally secreted by macrophages, the scavenger cells of the immune system, is secreted at significantly reduced levels in patients with HIV-related dementia.

The protein, known as lysozyme, is an anti-viral, anti-bacterial enzyme found in human monocytes (which differentiate into macrophages), which circulate in the blood stream but migrate as macrophages to the brain and other organs to fight infection.

Monocyte/macrophages are known to become infected by HIV in the bloodstream, but unlike the immune system's T-cells, they are not killed when infected. (The virus continues to infect the macrophages even in the presence of highly active antiretroviral therapy (HAART).) Instead, the cells serve as a reservoir for the virus. As the cells sometimes migrate to the brain, they can give the virus access to the organ early in the infection.

The discovery that HIV-infected macrophages secrete lysozyme at dramatically reduced levels in HIV-demented patients suggests that the macrophages are no longer highly activated, but are, instead, dysfunctional and thus unable to fight HIV-1 or other infections, says lead researcher Lynn Pulliam, PhD, associate chief of staff for research at the SF Veterans Affairs Medical Center and UCSF professor of laboratory medicine and medicine.

In earlier studies, the researchers have shown that certain immune-system molecules secreted by HIV-infected monocyte/macrophages are toxic to the brain's neurons, or nerve cells. The new study identifies for the first time, says Pulliam, a specific protein in HIV-infected macrophages that is not secreted in patients with HIV-dementia.

It's possible, she says, that the protein could prove to be a marker to monitor the progression of HIV-associated dementia and serve as a possible target for treatment.

In their study, the researchers investigate
'"/>

Contact: Joan Aragone
jaragone@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-May-2004


Page: 1 2

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
3. Smart immune cells kill more cancer
4. New network of gastrointestinal immune cells discovered
5. Old T cells cripple immune function in the elderly
6. Novel p53 gene-based therapy boosts immune system and reduces tumor size
7. VGTI researchers help uncover why aging reduces immune system function
8. Brains immune system triggered in autism
9. Marine sponge leads researchers to immune system regulator
10. Mayo Clinic discovers one mechanism for why men and women differ in immune response
11. Longterm immune memory cells cells do not develop during chronic viral infections

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical ... to physician colleagues, skilled nursing facility medical directors and other clinicians at various ... Wound Care." , "At many of these conferences we get to educate other ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
Breaking Medicine Technology:
Cached News: