HOME >> MEDICINE >> NEWS
Key immune system protein reduced in HIV-associated dementia patients

Researchers at the San Francisco Veterans Affairs Medical Center and UCSF have discovered that an important protein normally secreted by macrophages, the scavenger cells of the immune system, is secreted at significantly reduced levels in patients with HIV-related dementia.

The protein, known as lysozyme, is an anti-viral, anti-bacterial enzyme found in human monocytes (which differentiate into macrophages), which circulate in the blood stream but migrate as macrophages to the brain and other organs to fight infection.

Monocyte/macrophages are known to become infected by HIV in the bloodstream, but unlike the immune system's T-cells, they are not killed when infected. (The virus continues to infect the macrophages even in the presence of highly active antiretroviral therapy (HAART).) Instead, the cells serve as a reservoir for the virus. As the cells sometimes migrate to the brain, they can give the virus access to the organ early in the infection.

The discovery that HIV-infected macrophages secrete lysozyme at dramatically reduced levels in HIV-demented patients suggests that the macrophages are no longer highly activated, but are, instead, dysfunctional and thus unable to fight HIV-1 or other infections, says lead researcher Lynn Pulliam, PhD, associate chief of staff for research at the SF Veterans Affairs Medical Center and UCSF professor of laboratory medicine and medicine.

In earlier studies, the researchers have shown that certain immune-system molecules secreted by HIV-infected monocyte/macrophages are toxic to the brain's neurons, or nerve cells. The new study identifies for the first time, says Pulliam, a specific protein in HIV-infected macrophages that is not secreted in patients with HIV-dementia.

It's possible, she says, that the protein could prove to be a marker to monitor the progression of HIV-associated dementia and serve as a possible target for treatment.

In their study, the researchers investigate
'"/>

Contact: Joan Aragone
jaragone@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
19-May-2004


Page: 1 2

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
3. Smart immune cells kill more cancer
4. New network of gastrointestinal immune cells discovered
5. Old T cells cripple immune function in the elderly
6. Novel p53 gene-based therapy boosts immune system and reduces tumor size
7. VGTI researchers help uncover why aging reduces immune system function
8. Brains immune system triggered in autism
9. Marine sponge leads researchers to immune system regulator
10. Mayo Clinic discovers one mechanism for why men and women differ in immune response
11. Longterm immune memory cells cells do not develop during chronic viral infections

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2017)... ... January 18, 2017 , ... PrideStaff, ... Vice President of Franchise Development, Paula Turner Pizarro, was recently featured on Fox ... features the insights of top business leaders from across the globe, provides viewers ...
(Date:1/18/2017)... ... January 18, 2017 , ... Dr. Farhan Qureshi is ... and implants dentistry. His modern dental practice has two convenient office locations in Alexandria ... Top Rated Dentist for the Alexandria area. This award confirms the fact ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... of the revolutionary Active Brake Technology (ABT), an innovative braking system that allows ... Active Brake Technology addresses one of the biggest concerns of beginner and intermediate ...
(Date:1/17/2017)... ... January 17, 2017 , ... Anesthesia Progress – Everyone ... choose the best drug option for each patient. Dentists have several general anesthesia alternatives ... outcomes. , Researchers from the Tokyo Dental College in Tokyo, Japan wanted to find ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting interview with medical expert ... that help everyone endure and pass through tough times, Dr. Bernie Siegel energizes ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)...  Tarix Orphan LLC today announced that the U.S. ... Disease (RPD) designation for the company,s drug candidate TXA127 ... a rare genetic skin disorder. There are currently no ... supportive care. "The RPD designation for TXA127 ... by the FDA in this indication," said Richard ...
(Date:1/18/2017)... -- After the recent election cycle, it is ... both for medical and recreational purposes are shifting. The evidence ... use of cannabis, but the focus is coming from both ... the North American legal cannabis market posted $6.7 billion in ... research projects sales will grow at a compound annual growth ...
(Date:1/18/2017)... Chinese Food and Drug Administration CSL CureVac ... Food and Drug Administration FORT Fresenius Pharmaceuticals ... Smith Klein GlaxoWellcome Global Influenza Programme ... Immune Targeting Systems Indian Association of Paediatrics ... & Johnson Krka Pharmaceuticals Medicago Medicare ...
Breaking Medicine Technology:
Cached News: