Key to proper blood vessel growth in eye and ear discovered

gnal, recognized throughout the body, risks triggering unwanted blood vessel growth, perhaps feeding undetected tumors.

By contrast, the growth signal the Hopkins team identified seems to function only in the developing retina, where it promotes capillary formation, and in the inner ear, where it appears to help maintain the capillary network. It isn't known yet whether the signal is used later in life.

"Growth of blood vessels, like growth of nerves, must be precisely controlled, given the almost identical vascular anatomy from individual to individual," says Nathans. "What we learn about blood vessel growth in the eye may point to likely control systems in other kinds of cells."

Postdoctoral fellow Yanshu Wang, Ph.D., co-first author of the report, started the investigation by examining changes in mice missing Frizzled-4, which is defective in one form of familial exudative vitreoretinopathy, or FEVR (pronounced "fever"). She found that the mice had remarkably similar blood vessel problems in the eye and ear as seen in an earlier study of mice missing Norrin, which is faulty in Norrie [sic] disease. Both diseases are characterized by problems in blood vessel development in the retina; people with Norrie disease also go deaf over time.

Because of the similarities Wang found, co-first author and postdoctoral fellow Quiang Xu, Ph.D., examined whether the Norrin and Frizzled-4 proteins interact. He found that the two proteins bound each other selectively and strongly, and that Norrin caused efficient activation of the Frizzled-4 signaling pathway.

"The Norrie disease gene was found almost 12 years ago, but until now no one had been able to figure out what its product protein did or how it caused the disease," says Nathans. "Because the proteins behind the Norrie disease and FEVR are parts of the same process, these aren't two diseases, they are really two versions of the same disease."

The scientists also examined the

Contact: Joanna Downer
Johns Hopkins Medical Institutions

Page: 1 2 3

Related medicine news :

1. Antimicrobials to prevent infection in major surgery are used properly only about half the time
2. Life-saving properties of beta blockers extend to more patients
3. Stanford researcher dusts off old drug; uncovers new anti-rejection properties
4. Many children improperly measured in doctors offices
5. UI-led study shows experimental anti-cancer drug also has anti-HIV properties
6. Secret agents secret revealed - shaken martinis have superior antioxidant properties to those that are stirred
7. A marker for new blood vessel formation in tumors
8. Acupuncture found to lower elevations in blood pressure
9. Diagnostic test for range of blood disorders on the horizon
10. Research suggests possible blood test for multiple sclerosis
11. Epstein-Barr virus protein crucial to its role in blood cancers

Post Your Comments:

(Date:12/14/2019)... ... 14, 2019 , ... For two years, the only hospital in the Middle ... the parking lot would make you think of the temporary buildings you would see ... devastated the old building and the hospital carried on, first in tents and then ...
(Date:12/9/2019)... , ... December 09, 2019 , ... WEDI , ... in health care information exchange and a trusted advisor to the U.S. Department of ... to its Board of Directors, election of Officers* as well as the re-election of ...
(Date:12/9/2019)... ... ... OCLI, a Spectrum Vision Partners (SVP) managed practice, has announced the addition ... practice with experience spanning decades. As part of OCLI, Drs. Cary Silverman, Nicholas Xanthos ... 46 Eagle Rock Ave, East Hanover, NJ 07936. , Over the past ...
(Date:12/8/2019)... ... December 07, 2019 , ... Intelligent.com, a trusted ... 55 Best Master of Science in Nursing (MSN) Degree Programs for 2020. The ... universities in the nation. Each program is evaluated based on curriculum quality, graduation ...
(Date:12/6/2019)... (PRWEB) , ... December 06, 2019 , ... ... recruiting, has been recognized for excellence in employee learning. The Omaha-based company has ... ranks organizations with the most successful employer-sponsored training and development programs worldwide. Rankings ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... , ... December 06, 2019 , ... ... development of treatments for psychiatric and neurodegenerative disorders, announced today that the U.S. ... for NBTX-001 Inhaler, allowing the Company to initiate its Phase 2b trial for ...
(Date:12/6/2019)... ... December 06, 2019 , ... Food and nutrition industry ... and ideas about working toward sustainable nutrition security nationwide, increasing accessibility to nutritious ... develop a healthy and sustainable food system,” said Carol May, CEO of Wisdom ...
(Date:12/6/2019)... , ... December 06, 2019 , ... ... agreement with Forbidden Fruit Garden Supply LLC (a division of Horticultural Holdings LLC) ... clientele of professional growers. , FFGS is a team of disciplined and ...
Breaking Medicine Technology:
Cached News: