HOME >> MEDICINE >> NEWS
Kidney disease in diabetics relates to insulins effectiveness, say Pittsburgh researchers

PITTSBURGH, Sept. 1 Insulin resistance, a condition commonly associated with the development of type 2 diabetes, is likely a major cause of kidney disease, or nephropathy, in people with type 1 diabetes, according to study results published by University of Pittsburgh Graduate School of Public Health (GSPH) researchers in the September issue of Kidney International, a journal of the International Society of Nephrology.

"Kidney disease is a major lethal complication for people with diabetes, particularly those with type 1 diabetes, and until now there has been no clear explanation for its cause beyond blood sugar itself," said principal investigator Trevor Orchard, M.D., professor and acting chair, department of epidemiology, GSPH. "We now suspect that reducing or preventing insulin resistance, possibly through exercise, weight loss and drugs, may help people with type 1 diabetes avoid nephropathy."

The study analyzed data from the Pittsburgh Epidemiology of Diabetes Complication Study (PEDCS), a 10-year prospective investigation based on a cohort of adults with type 1, or childhood-onset, diabetes. Of the 658 subjects in PEDCS, 485 did not have nephropathy at baseline and were followed for the current study.

Fifty-six of the 485 subjects developed nephropathy during either the first five years of follow-up, or during years 6-10. Researchers found that in all cases, strong relationships existed between nephropathy and insulin resistance throughout follow up, unlike other risk factors such as blood pressure and blood fats, which only predicted nephropathy in the short term.

To measure insulin resistance, investigators used a novel calculation based on waist-to-hip ratio, hypertension status and long-term blood sugar levels.

"Although our measure of insulin resistance is an estimate based on easier-to-measure factors, it is strongly correlated with the gold standard euglycemic clamp studies and clearly stands out as the leading p
'"/>

Contact: Kathryn Duda
412-624-2607
University of Pittsburgh Medical Center
1-Sep-2002


Page: 1 2

Related medicine news :

1. Kidney cancer surgery safer at high-volume hospitals
2. Kidney transplant patients who develop diabetes show poor short-term outcomes
3. Kidney transplant proposal reduces wait from 24 to 14 months, improves equity for blacks & women
4. Kidney Transplants From Living Donors Reduce Long-Term Costs Of Care
5. The Break Even Cost Of Kidney Transplants Is Shrinking
6. Kidney Transplant Recipients Require Less Long-Term Care If They Receive Well-Matched Donor Organs
7. New Strategy May Succeed At Extending The Life Of Transplanted Kidneys
8. Immunex Advances CD40 Ligand To Phase II Clinical Trial In People With Metastatic Kidney Cancer
9. Maternal Tissue Typing Could Improve Selection Of Kidney Transplant Donors
10. Researchers Begin Drug Trial In Hope Of Finding New Ways To Treat Acute Kidney Failure
11. Organ Rejection Drug Also Shows Promise For The Treatment Of Kidney Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2017)... CITY, UTAH (PRWEB) , ... April 28, 2017 ... ... as Account Manager for the North East region. Côté has 20+ years of ... consulting. Prior to Phytomer, Côté worked with an array of high-end cosmetic brands, ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... and advanced nutraceutical supplements, through its Nova Skin Sciences division, recently announced ... benefits of a moisturizer with the power of an anti-aging concentrate. ...
(Date:4/28/2017)... ... 28, 2017 , ... Rob Lowe is a popular actor that has been ... to an educational purpose as the host of the “Informed” series. The program focuses ... recent episode, the series focuses on thyroid cancer. , Although thyroid cancer is an ...
(Date:4/28/2017)... ... 2017 , ... Christie Medical Holdings, Inc. , with its market-leading ... Medical Inc. , a leader in infusion therapy and pain management. , Intravenous ... percent of hospital patients receiving a peripheral IV catheter as part of their treatment ...
(Date:4/27/2017)... ... April 27, 2017 , ... The Incentive ... and Recognition: A Nudge Guide," a groundbreaking analysis of how behavioral economics can ... to apply immediately to IRR programs, the report highlights proven behavioral economics approaches ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
(Date:4/20/2017)... Research and Markets has announced the addition of the ... Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2014 ... ... US$ 7,167.6 Mn in 2015, and is expected to reach ... 5.6% from 2016 to 2024. The global ...
(Date:4/19/2017)... 2017 Cardiology devices segment is anticipated to reach ... The Cardiology Devices segment is likely to create absolute $ ... 2018 over 2017. By the end of 2027, Cardiology Devices ... US$ 700 Mn, expanding at a CAGR of 18.4% over ... Asia Pacific reprocessed medical devices market in ...
Breaking Medicine Technology:
Cached News: