HOME >> MEDICINE >> NEWS
Knock out blood protein drug signals possible new treatment for Alzheimer's and diabetes

LONDON 15 MAY - Scientists at UCL have developed a drug to treat a serious medical condition linked to Alzheimer's disease and type 2 diabetes. The research, supported by the Medical Research Council (MRC) and reported in NATURE, is the culmination of 25 years of basic and clinical research and the UCL scientists hope that it may be the key to the treatment of other serious diseases.

Crucially, Professor Mark Pepys and his team have managed for the first time to remove from the human body a naturally occurring blood protein - known as SAP - that is linked to development of the disease.

Amyloidosis - a disorder in which the body's own proteins accumulate as abnormal fibres that damage organs and tissues leading to disease - claims the lives of 1,000 people in the UK every year. All parts of the body can be affected. Also amyloid deposits localised to the brain are associated with Alzheimer's disease and those in the pancreas with type 2 diabetes.

The research team, based at the UCL Centre for Amyloidosis and Acute Phase Proteins at the Royal Free Hospital, first showed that SAP from the blood contributes to amyloid deposition by sticking to amyloid fibres. They then set out to produce a drug to prevent this. Working with Roche, a new drug called CPHPC was developed that blocks the sticking of SAP to amyloid.

The NATURE research reveals how the new drug was developed and outlines the mechanisms that cause SAP to be removed from the blood. The drug glues pairs of SAP molecules tightly together and the resulting clump of protein is then promptly removed from the blood by the liver and destroyed. Disappearance of SAP from the blood greatly speeds up the removal of SAP from the amyloid deposits in the tissues. Importantly, the research means that CPHPC can also be used to remove SAP from amyloid deposits in the brain in Alzheimer's disease. The first clinical studies in Alzheimer patients are about to start.

Patients with s
'"/>

Contact: Patrick Edwards
media@ucl.ac.uk
44-20-7679-1621
University College London
15-May-2002


Page: 1 2

Related medicine news :

1. A marker for new blood vessel formation in tumors
2. Acupuncture found to lower elevations in blood pressure
3. Diagnostic test for range of blood disorders on the horizon
4. Research suggests possible blood test for multiple sclerosis
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. Simple blood test may help to predict cardiovascular risk in older women
7. Drug that hinders blood vessel growth under study in ovarian cancer
8. Laughter helps blood vessels function better
9. St. Johns wort amplifies effect of blood thinner Plavix
10. Latest findings on genetic blood disorder Cooleys Anemia
11. Can routine commercial cord blood banking be scientifically and ethically justified?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... Since the registration ... Century Cures Act in the US, Nocimed has been marketing its unique technology ... images from existing MRI equipment to perform MR spectroscopy, NociScan detects the presence ...
(Date:9/17/2019)... Village, CA (PRWEB) , ... September 17, 2019 ... ... in Westlake Village, CA, incision-free treatment with laser dentistry . A minimally ... to perform than traditional osseous surgery. , Laser dentistry is gentle and ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... largest accountable care organization (ACO) in the country, the company announced today. High-performing ... to improve care quality and increase cost efficiency. This opportunity is open to ...
(Date:9/17/2019)... ... , ... Lubin Austermuehle, P.C. will be one of the sponsors ... held at Found Kitchen and Social House in Evanston on Monday, October 7 from ... Disorder, a rare condition that results from changes to the GRIN2B gene. The GRIN2B ...
(Date:9/17/2019)... ... September 17, 2019 , ... Specialty Technical Publishers (STP) ... Audit Protocol Consortium (IAPC) EHS audit protocol for Japan . Leading companies ... their EHS regulatory obligations and rapidly collect, share, archive, and export audit findings ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... ... September 17, 2019 , ... Today, in partnership with ... contraception and consent with student and faculty from The City University of New ... Francisco Ramirez, MPH; Elise Schuster, MPH; Raffaele M. Bernardo, DO, FACP, AAHIVS and ...
(Date:9/17/2019)... ... September 17, 2019 , ... Embr Labs , the ... Series B funding led by DigiTx Partners, with participation from Safar Partners, ... use the investment to grow the company’s footprint in wellness and digital therapeutics, accelerate ...
(Date:9/17/2019)... ... September 17, 2019 , ... Gustavo Grodnitzky, PhD will join the ... Yoga Science as holistic mind/body medicine for physicians and other health care professionals. Entitled ... 22-26, 2019 at the Cranwell Resort and Spa in Lenox, Massachusetts, is accredited by ...
Breaking Medicine Technology:
Cached News: