HOME >> MEDICINE >> NEWS
Knock out blood protein drug signals possible new treatment for Alzheimer's and diabetes

LONDON 15 MAY - Scientists at UCL have developed a drug to treat a serious medical condition linked to Alzheimer's disease and type 2 diabetes. The research, supported by the Medical Research Council (MRC) and reported in NATURE, is the culmination of 25 years of basic and clinical research and the UCL scientists hope that it may be the key to the treatment of other serious diseases.

Crucially, Professor Mark Pepys and his team have managed for the first time to remove from the human body a naturally occurring blood protein - known as SAP - that is linked to development of the disease.

Amyloidosis - a disorder in which the body's own proteins accumulate as abnormal fibres that damage organs and tissues leading to disease - claims the lives of 1,000 people in the UK every year. All parts of the body can be affected. Also amyloid deposits localised to the brain are associated with Alzheimer's disease and those in the pancreas with type 2 diabetes.

The research team, based at the UCL Centre for Amyloidosis and Acute Phase Proteins at the Royal Free Hospital, first showed that SAP from the blood contributes to amyloid deposition by sticking to amyloid fibres. They then set out to produce a drug to prevent this. Working with Roche, a new drug called CPHPC was developed that blocks the sticking of SAP to amyloid.

The NATURE research reveals how the new drug was developed and outlines the mechanisms that cause SAP to be removed from the blood. The drug glues pairs of SAP molecules tightly together and the resulting clump of protein is then promptly removed from the blood by the liver and destroyed. Disappearance of SAP from the blood greatly speeds up the removal of SAP from the amyloid deposits in the tissues. Importantly, the research means that CPHPC can also be used to remove SAP from amyloid deposits in the brain in Alzheimer's disease. The first clinical studies in Alzheimer patients are about to start.

Patients with s
'"/>

Contact: Patrick Edwards
media@ucl.ac.uk
44-20-7679-1621
University College London
15-May-2002


Page: 1 2

Related medicine news :

1. A marker for new blood vessel formation in tumors
2. Acupuncture found to lower elevations in blood pressure
3. Diagnostic test for range of blood disorders on the horizon
4. Research suggests possible blood test for multiple sclerosis
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. Simple blood test may help to predict cardiovascular risk in older women
7. Drug that hinders blood vessel growth under study in ovarian cancer
8. Laughter helps blood vessels function better
9. St. Johns wort amplifies effect of blood thinner Plavix
10. Latest findings on genetic blood disorder Cooleys Anemia
11. Can routine commercial cord blood banking be scientifically and ethically justified?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2019)... ... June 20, 2019 , ... The 2019 Colorado Classic® presented by ... and four top-20 UCI women’s elite teams, organizers announced today. The top-four domestic ... be coming to the race. , The standalone pro women’s road race has ...
(Date:6/19/2019)... ... ... CEO Steven C. Bilt of Smile Brands Inc. has won a Glassdoor ... , one of the world’s largest job and recruiting sites, released its annual report ... throughout North America and parts of Europe. , Smile Brands, a leading dental support ...
(Date:6/19/2019)... ... June 19, 2019 , ... The FSH ... (IRC) in Marseille, France. The conference is widely seen as the premier ... dystrophy (FSHD). Nearly 200 researchers, clinicians, industry representatives and patient advocates are attending. ...
(Date:6/19/2019)... LOS ANGELES (PRWEB) , ... June 19, 2019 , ... ... 35th European Society of Human Reproduction and Embryology (ESHRE) Annual Meeting in ... in IVF has been pre-selected for consideration for both the Basic Science Award for ...
(Date:6/18/2019)... (PRWEB) , ... June 18, 2019 , ... ... sponsors/partners have been added to its joint conference with the Houston Healthcare HR ... and panelists at the conference, HR Maximizer welcomes Staywell, Walden University, PageUp, CRC, ...
Breaking Medicine News(10 mins):
(Date:6/24/2019)... ... June 24, 2019 , ... ... to provide breathability and comfort for the electrical industry has today announced the ... safety. , The guide, titled Developing a Culture of Electrical Safety, is ...
(Date:6/20/2019)... PHILADELPHIA (PRWEB) , ... June 20, 2019 , ... ... health products, was recently named one of the Philadelphia Business Journal’s Healthiest Employers ... company’s Wellness@Work Director, Vicki Wolf, accepted the award during a ceremony at the ...
(Date:6/20/2019)... ... 2019 , ... A study released today in STEM CELLS ... to treat acute respiratory distress disorder (ARDS). This important information could point to ... Ben Antebi, Ph.D., who led the team of investigators from the U.S. Army ...
Breaking Medicine Technology:
Cached News: