HOME >> MEDICINE >> NEWS
Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response

LOS ANGELES (Oct. 22, 2004) Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute have described an immune-disruptive process driven by an enzyme that is overexpressed in the cells of many types of tumors, including malignant brain tumors called gliomas.

Blocking the enzyme's expression in laboratory tests interrupted the series of cell-level events and led to the development of cells capable of launching an immune response. This finding supports the suggestion that medications attacking the enzyme may boost the immune system's ability to recognize and target gliomas.

Results of the study on cyclooxygenase-2 (COX-2) appear in the October 1 issue of the Journal of Immunology. While COX-2 inhibition has been considered an attractive anti-cancer strategy, results of earlier studies on a variety of tumors have been inconsistent, puzzling and sometimes seemingly contradictory. Furthermore, because COX-2 is a complex enzyme that is affected by a variety of conditions and biochemical substances, many of its mechanisms and effects are not clearly understood.

In the article, Institute researchers describe COX-2's detrimental influence on dendritic cells the immune system cells responsible for detecting foreign matter and eliciting an immune response. Dendritic cells, highly specialized "antigen-presenting cells," pick up debris left behind when cells die. When they take up and process debris from tumor cells, they should present these antigens to cytotoxic T lymphocytes (CTL), cancer killing cells, instructing them to attack the tumor cells.

If functioning properly, the dendritic cells would induce the production of a protein called interleukin-12 (IL-12), which prompts the immune system's CD4+ T lymphocytes to launch a T helper type 1 (Th1) response attack mode. Lymphocytes would swarm to the source of the antigens and attack the tumor cells.

Instead, the researchers found, COX-2 and a hormone-like substance it synth
'"/>

Contact: Sandra Van
sandy@vancommunications.com
1-800-880-2397
Cedars-Sinai Medical Center
22-Oct-2004


Page: 1 2 3

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... ... PathAI, a global provider of artificial intelligence (AI)-powered technology for use in pathology ... expression to assess response in patients treated with Bristol Myers Squibb’s PD-1 inhibitor, nivolumab ... (AACR) Annual Meeting. AACR was held June 22 to June 24. , The key ...
(Date:6/28/2020)... , ... June 27, 2020 , ... ... Classroom, the first online, full-day educational conference in the organization’s history. The online ... facioscapulohumeral muscular dystrophy (FSHD), which was cancelled this year due to COVID-19. Nearly ...
(Date:6/24/2020)... ... 24, 2020 , ... Evolved Naturals, a new brand of CBD health and ... The newly launched website showcases a variety of health and beauty CBD ... line of skincare & topical products . , Doug Gee, the CEO ...
(Date:6/24/2020)... ... June 24, 2020 , ... The world’s largest cell phone trade-in price comparison ... cell phones will be worth the most two years after purchase. , The ... Samsung, Google, Sony and LG - and compared their 2018 MSRP with their trade ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... challenging for patients and providers alike. The virus, which is primarily found in ... and spreads through respiratory droplets, contact contamination, or by aerosols produced during aerosol-generating ...
Breaking Medicine News(10 mins):
(Date:6/25/2020)... ... 2020 , ... Billon Group received a £50,000 grant in ... to store COVID-19 related certificates to support workers’ safe return to the workplace. ... publishing, sharing and verifying a wide array of workplace training or medical test ...
(Date:6/25/2020)... (PRWEB) , ... June 25, 2020 , ... The Heritage ... have had zero cases of COVID-19. With over 100,000 positive cases of the coronavirus ... the senior citizens who reside at The Heritage Downtown, their family members, as well ...
(Date:6/25/2020)... ... June 25, 2020 , ... Drs. Gregory ... Dentist list within the Periodontics category. As specialists, this team of periodontists ... and Westerly, RI. Laser gum disease therapy, minimally invasive gum recession treatment, and ...
Breaking Medicine Technology:
Cached News: