HOME >> MEDICINE >> NEWS
Lack of specific collagen type leads to osteoarthritis

DURHAM, N.C. Duke University Medical Center researchers have found that joints whose cartilage lacks a specific type of collagen will develop osteoarthritis the so-called "wear-and-tear" form of the disease at a greatly accelerated rate.

The results of their experiments with mice provide new insights that could lead to potential treatments for a disease that afflicts more than 40 million Americans, said the researchers.

The researchers found that mice lacking the gene that controls the production of type VI collagen developed osteoarthritis at a rate more than five times greater than mice with a functioning gene. Collagen is a ubiquitous protein found throughout the body in connective tissue, muscle, cartilage and bone. To date, 27 different types have been identified.

To examine structures within the cartilage of mouse joints, Leonidas Alexopoulos, Ph.D., developed a novel "micro-vacuuming" technique. With this device, Alexopoulos extracted key structures within the cartilage of mouse hip joints, which are the size of the ball in a ball-point pen, and analyzed how they responded to the stresses of everyday life.

Alexopoulos presented the results of the Duke study Feb. 20, 2005, at the 51th annual scientific meeting of the Orthopedic Research Society in Washington, D.C. Alexopoulos, now a post-doctoral fellow at the Massachusetts Institute of Technology, conducted the research in the laboratory of Farshid Guilak, Ph.D., director of orthopedic research and senior member of the Duke team. The study was funded by the National Institutes of Health.

The researchers focused their attention on the narrow region of tissue that surrounds the cartilage cells on the surface of joints and is known as the pericellular matrix (PCM). Together with cartilage cells known as chondrocytes, collagen types II, VI and IX, and other proteins, the PCM forms a structure called a chondron, which is believed to provide a "buffer" zone between the cel
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
20-Feb-2005


Page: 1 2 3

Related medicine news :

1. Culture-specific exercise sparks interest of older women
2. Twice daily imatinib could improve outcome for people with specific form of gastro-intestinal cancer
3. One dose of designer gene therapy may target specific body area
4. U of MN study first to detect tobacco-specific carcinogens in non-smokers in public setting
5. Scientists explain why Crohn disease is localized to specific regions of the gut
6. First ethnicity-specific erectile dysfunction study shows prevalence among Hispanic American men
7. First report of stem cell signal of intention to become specific neuron
8. Aspirin and other non-specific COX inhibitors may slow atherosclerosis
9. Gender-specific intervention may be needed to improve diets of african-american youth
10. Virco first to introduce drug-specific biological cut-offs for its HIV resistance tests
11. Selective inhibitor can target specific enzyme that promotes cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... 2020 , ... In its often-heroic ongoing response to the ... the obstacle - shortages of tests, ventilators and ICU beds; strained lab capacity; ... of all nonessential services - providers across the country have found new and ...
(Date:8/5/2020)... , ... August 05, 2020 , ... CentrAlert, Inc. ... help everyone gain access to essential COVID-19 information. Know NOW!, which is available for ... COVID-19 updates and unify them in one easy-to-use mobile application. , “When COVID-19 first ...
(Date:8/5/2020)... ... August 04, 2020 , ... Today, Power to Decide’s One Key Question ... the 2020 Innovation Station Best Practice Award. The One Key Question program is a ... get pregnant and have a child. One Key Question is used by thousands of ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... announced enrollment of the first patients with first-line advanced pancreatic cancer in a ... 1/2 1801 trial of 9-ING-41, (NCT03678883, EudraCT#:2018-003739-32). 9-ING-41 is Actuate’s proprietary small ...
(Date:7/31/2020)... ... July 31, 2020 , ... National Association of ... statement today regarding the nation’s ongoing preparations for the eventual deployment of COVID-19 ... an efficient, effective and essential component of vaccine deployment. They will need to ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... The Urgent Care Association (UCA), College of ... collaborating to present a virtual education on acute flaccid myelitis (AFM), an uncommon but ... 1 p.m. CT on July 14, 2020. , AFM, which is most prevalent ...
(Date:7/7/2020)... , ... July 07, 2020 , ... ... its partnership with Psych Hub, the leading comprehensive platform for online education on ... to offer support resources to Substance Use Disorder (SUD) patients throughout each step ...
(Date:7/7/2020)... ... July 07, 2020 , ... To support those on the ... Change (WGC), will be providing meals to the employees of Southern Nevada Health District. ... throughout Las Vegas on Wednesday, July 8th. , When asked why the Women of ...
Breaking Medicine Technology:
Cached News: