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Landmark XENDOS study shows Xenical prevents or delays the development of type 2 diabetes

7.5 kg at one year and -6.9 vs -4.1kg at four years)

Weight loss was successfully maintained in the long-term, with almost twice as many Xenical treated patients losing more than 10% body weight at the end of four years of treatment (26% vs 16%). Even more patients had lost more than 5% body weight after four years (53% vs 37%), an amount that has been shown to have clear health benefits

Xenical-treated patients had significant, sustained, long-term improvements in cardiovascular risk factors such as blood pressure and lipid profiles compared with lifestyle intervention alone

Treatment with Xenical for 4 years was safe and well-tolerated. Xenical is now the only weight loss medication available whose safety has been studied for this length of time

Type 2 diabetes

Worldwide, the prevalence of overweight and obesity is growing at an epidemic rate, with a corresponding surge in the incidence of type 2 diabetes. It is estimated that there are at least 150 million people in the world with diabetes and that type 2 diabetes accounts for 90 per cent of all cases. This figure is expected to double over the next 25 years. Because of the severe health & cost complications of type 2 diabetes, organisations such as the International Diabetes Federation (IDF) have called for increased efforts to prevent the development of type 2 diabetes. President of the IDF, Professor George Alberti, stated recently that "The importance of diabetes prevention cannot be underestimated".2

Excess weight

Excess weight is well recognised as the most important modifiable risk factor for the development of type 2 diabetes. A number of recent studies have shown that lifestyle intervention (to reduce weight and increase physical activity) has a dramatic effect on delaying or preventing the development of type 2 diabetes3,4. As a result of these findings, authorities currently recommend lifestyle intervention as the most effective treatment approach to preventing
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Contact: Antonia Betts
antonia.betts@sh-international.com
917-295-2335
Shire Health International
26-Aug-2002


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