HOME >> MEDICINE >> NEWS
Latest cancer research features small molecule therapy, and the preventative benefits of sunshine

ORLANDO Among the latest breaking cancer research presented today scientists described a small molecule that locks into DNA structures, inhibiting the expression hard-to-target oncogenes. In another application a of small molecule targeted drug therapy, an agonist turns on a gene-regulating pathway to inhibit growth and metastasis in deadly thyroid tumors. From down under, Australian researchers found that sun worshippers are taking steps to prevent non-Hodgkin Lymphomas. This research was presented here at the 95th Annual Meeting of the American Association for Cancer Research.

In vivo cfficacy of CX-3543, a novel c-Myc oncogene inhibitor: Abstract No. LB-243

Cancer researchers today unveiled a new small molecule drug that specifically targets c-Myc, a key growth promoting regulator in cancers and a gene that has escaped all efforts to control it.

William Rice, Ph.D., the presenting author on a team of scientists from Cylene Pharmaceuticals, San Diego, Calif., said that the small molecule CX-3543 effectively reduced cMyc mRNA expression by 85 percent in colorectal tumor animal models. The small molecule inhibited growth of prostate and pancreatic tumor models in mice as well. Each of those tumor cell types are known to produce high levels of cMyc during tumor growth.

"We have identified a small molecule with drug-like properties that is a candidate for further preclinical development," Rice said.

CX-3543 selectively suppresses cMyc activity by specifically binding to the cMyc quadruplex, he said. G-quadruplex structures are four stranded DNA secondary structures. Certain G-quadruplexes regulate transcription of specific oncogenes, including cMyc. The quadruplex cluster that includes cMyc also includes VEGF, a growth factor that regulates development of blood vessels to tumors. CX-3543 inhibits VEGF expression as well as cMyc.

"We selected CX-3543 as the first 'Oncog
'"/>

Contact: Aimee Frank
amf@spectrumscience.com
202-955-6222
American Association for Cancer Research
31-Mar-2004


Page: 1 2 3 4

Related medicine news :

1. Latest findings on genetic blood disorder Cooleys Anemia
2. Latest Asian-American tobacco use data reported
3. Latest Public Policy & Aging Report forecasts possible US labor shortage
4. Latest results from international islet transplant study confirm potential patient benefits
5. Latest fashion fad concerns eye M.D.s
6. Latest research in allergic disease to be presented at the 2004 AAAAI Annual Meeting
7. Latest advances in end-of-life care to be featured at Tampa conference
8. Latest research on possible causes of violent behavior explored in C&EN article
9. Latest child neurology practices and studies presented at daylong briefing
10. Treatment-Resistant Depression: Results of Latest Electromagnetic Stimulation Study Show Promise
11. Worlds Premier Pharmaceutical Scientists Share Latest R&D Findings

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... ... May 21, 2020 , ... ... health management platform that supports care management and utilization management at health insurance ... client sites, TruCare 2020 provides significant usability and automation upgrades to all of ...
(Date:5/16/2020)... ... , ... For patients who have gone to see Andy Gaertner, D.M.D , in the ... in place. After being allowed to re-open during the current pandemic, they have put some ... safe and comfortable as possible while going through their dental exams and treatments. , The ...
(Date:5/15/2020)... ... May 15, 2020 , ... COVID-19 has made people feel ... by making sure their employees can get back to work safely. Their unique line ... to gyms, restaurants, bars, and countless other settings. , Everyone needs to be able ...
(Date:5/15/2020)... ORLANDO, Fla. (PRWEB) , ... May 15, 2020 , ... ... mitigate the spread of Coronavirus. There is a need to combat the spread of ... and guests. This is where Touchrate hopes to help with their TempCheck Sentinel and ...
(Date:5/14/2020)... BAY, Fla. (PRWEB) , ... May 14, 2020 , ... SGF , a premier ... comprehensive suite of fertility procedures and treatment in the Tampa Bay region. , “While this ... the many ways our team members and patients have risen to the occasion. Through the ...
Breaking Medicine News(10 mins):
(Date:5/21/2020)... ... 2020 , ... Today Anyblock Analytics, a German firm noted ... Many facilities, cities, states/provinces, and countries are eager to begin re-opening their economies. ... million in the United States alone—serious concerns remain about how to do so ...
(Date:5/21/2020)... ANGELES (PRWEB) , ... May 21, 2020 , ... Labyrinthe ... muscle support formula called Lefa . A soothing cream designed for fast-action relief ... of whole plant phytocannabinoids proven to soothe and support tired joints and muscles. ...
(Date:5/16/2020)... (PRWEB) , ... May 15, 2020 , ... ... Chinese medicine to treat fatigue, impotence, constipation, frequent urination and joint pain, but ... cucumbers possess the ability to boost the immune system , naturally. , ...
Breaking Medicine Technology:
Cached News: