Leading cancer doctor calls for new guidelines to control early reporting from clinical trials

from one of the trials (MA17 trial on the AI, letrozole) had, in effect, "killed" a sister trial looking at another AI, exemestane, instead of letrozole for extended adjuvant therapy, and other studies were in danger too.

"I suggest that guidelines should be drawn up and agreed by the research community, whereby early disclosure is based on significant differences between the rates of distant relapse. Distant relapses mean the cancer recurring in lung, liver or bone, for which there is almost no chance of cure, in contrast to relapses in the breast and regional nodes for which curative therapy exists. I will be putting this proposal to the Breast International Group and, if deemed appropriate, it will be discussed with its closest partner, the North American Breast Intergroup."

Her remarks come hot on the heels of the announcement last week that exemestane, a steroidal aromatase inhibitor (SAI), was more effective than tamoxifen in preventing cancer returning in women whose breast cancer had been caught early. This trial, led by Professor Charles Coombes of Imperial College London, reported early, although 90 per cent of participants had completed their therapy by this time.

Dr Piccart warned that big questions still remain about the long-term effects and effectiveness of AIs, and she urged physicians to make "individualized" treatment decisions with their patients.

"Although there have been several trials now that show positive results for AIs, the long-term effects are still unclear. Questions remain about their effect on bone and cardiovascular health, cognitive and sexual function, and quality of life," she said. "The biggest question is which will be the optimal new endocrine therapy: an AI upfront instead of tamoxifen or a few years of tamoxifen followed by an AI? Also, should the AI be given for two or three years, or for five years, as is now current practice with tamoxifen? At present no-one can say what is the best tre

Contact: Emma Mason
Federation of European Cancer Societies

Page: 1 2 3

Related medicine news :

1. Leading researchers in allergic disease to gather for 2005 AAAAI Annual Meeting
2. Leading tobacco manufacturer conceals links to tobacco research facility
3. Leading MRSA experts address emergence of superbug
4. Leading causes of blindness for blacks and whites different
5. Leading AIDS experts criticize US-sponsored HIV vaccine trial in Thailand
6. Leading the way in novel anti-cancer research
7. Leading American, German chemists converge to share research, vision
8. Leading anti-cancer factions strengthen bonds
9. Leading NIH-funded medical schools agree on guidelines that would strenghten conflict of interest policies
10. Biochemical Marker Targets Brain Injury Leading To Movement Problems After Stroke
11. New Model Shows How To Eradicate Worlds Leading Infectious Cause Of Blindness

Post Your Comments:

(Date:12/14/2019)... ... 14, 2019 , ... For two years, the only hospital in the Middle ... the parking lot would make you think of the temporary buildings you would see ... devastated the old building and the hospital carried on, first in tents and then ...
(Date:12/9/2019)... , ... December 09, 2019 , ... WEDI , ... in health care information exchange and a trusted advisor to the U.S. Department of ... to its Board of Directors, election of Officers* as well as the re-election of ...
(Date:12/9/2019)... ... ... OCLI, a Spectrum Vision Partners (SVP) managed practice, has announced the addition ... practice with experience spanning decades. As part of OCLI, Drs. Cary Silverman, Nicholas Xanthos ... 46 Eagle Rock Ave, East Hanover, NJ 07936. , Over the past ...
(Date:12/8/2019)... ... December 07, 2019 , ... Intelligent.com, a trusted ... 55 Best Master of Science in Nursing (MSN) Degree Programs for 2020. The ... universities in the nation. Each program is evaluated based on curriculum quality, graduation ...
(Date:12/6/2019)... (PRWEB) , ... December 06, 2019 , ... ... recruiting, has been recognized for excellence in employee learning. The Omaha-based company has ... ranks organizations with the most successful employer-sponsored training and development programs worldwide. Rankings ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... , ... December 06, 2019 , ... ... development of treatments for psychiatric and neurodegenerative disorders, announced today that the U.S. ... for NBTX-001 Inhaler, allowing the Company to initiate its Phase 2b trial for ...
(Date:12/6/2019)... ... December 06, 2019 , ... Food and nutrition industry ... and ideas about working toward sustainable nutrition security nationwide, increasing accessibility to nutritious ... develop a healthy and sustainable food system,” said Carol May, CEO of Wisdom ...
(Date:12/6/2019)... , ... December 06, 2019 , ... ... agreement with Forbidden Fruit Garden Supply LLC (a division of Horticultural Holdings LLC) ... clientele of professional growers. , FFGS is a team of disciplined and ...
Breaking Medicine Technology:
Cached News: