HOME >> MEDICINE >> NEWS
Less Toxic Bone Marrow Transplant Technique May Have More Powerful Anti-Cancer Effect

A research team from the Massachusetts General Hospital (MGH) has shown that it is possible to transplant bone marrow successfully from mismatched human donors without the usual pre-transplant destruction of the patient's own bone marrow. The report appears in the May 22 issue of The Lancet.

The scientists from the hospital's Bone Marrow Transplant Program and Transplantation Biology Research Center (TBRC) successfully induced a state of mixed chimerism - in which the immune systems from both donor and recipient are blended - in four patients with aggressive non-Hodgkins lymphomas that resisted other treatment methods. Two of those patients have achieved long-term remission without significant graft-versus-host disease, a dangerous complication of bone marrow transplantation.

"This proof-of-principal study has shown that we can achieve a lasting combination of donor and recipient immune systems without the kind of toxic treatment usually used to wipe out the recipient's bone marrow," says Megan Sykes, M.D., of the TBRC, the paper's lead author. "We are intrigued by the powerful anti-tumor effect observed in several patients."

Thomas Spitzer, M.D., director of the Bone Marrow Transplant Program and principal investigator of the study described in the Lancet paper, adds, "While it's much too early to say whether this approach will benefit and be safe for all patients with advanced blood-cell cancers, we're very encouraged by the results we've seen."

In standard bone marrow transplantation, patients undergo a pre-transplant process called ablation in which their diseased bone marrow is destroyed by either intense radiation or chemotherapy, essentially wiping out their immune system. Depending on the patient's particular illness, replacement marrow may come from a donor or may be the patient's own marrow treated to remove any malignant cells (an autologous transplant). In the case of treatment-resistant non-Hodgkins lymphoma, a blood-cell canc
'"/>

Contact: Susan McGreevey
smcgreevey@partners.org
617 724-2764
Massachusetts General Hospital
21-May-1999


Page: 1 2 3

Related medicine news :

1. 2005 Pharmacology, Therapeutics, & Toxicology Research Award
2. 2004 Pharmacology/Therapeutics/Toxicology Award to Haas
3. BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent
4. Marrow injection gets damaged hearts moving
5. Organ Transplants Helped By Donor Bone Marrow, University Of Pittsburgh Researchers Report At National Transplant Meetings
6. Bone Marrow With Heart And Lung Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
7. Bone Marrow With Organ Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
8. Duke Researchers Identify New Pulmonary Syndrome Associated With Bone Marrow Transplantation For Breast Cancer
9. Transplanted bone marrow cells reduce liver fibrosis in mice
10. Transplant of pig tissue may reduce stroke size and damage
11. Roche pledges continued support for Organ Transplantation Research Foundation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
Breaking Medicine Technology:
Cached News: