HOME >> MEDICINE >> NEWS
Lipid abnormalities linked to Lou Gehrigs disease

Abnormal accumulation of two common lipids in motor nerve cells could play a critical role in the development of amyotrophic lateral sclerosis (ALS), according to investigators at the National Institute on Aging (NIA) in Baltimore. The finding could help scientists develop drugs and other treatments that might one day slow or arrest the disease's progression.

"ALS is a terrible disease in which a fully functioning mind is trapped inside a body that is becoming progressively paralyzed. At the present time, nothing can be done for ALS, but we hope this newly established link between lipid regulation and the disease will hasten the development of new treatments," said Mark Mattson, Ph.D., lead author of the study* and chief of the NIA Laboratory of Neurosciences. Lipids are the building blocks of fats. The study is available online at the Annals of Neurology website, http://www3.interscience.wiley.com/ and will be published in the journal's September 2002 issue.

Also called Lou Gehrig's disease, ALS is a progressive, fatal neurological disease affecting as many as 20,000 Americans, with 5,000 new cases occurring in the United States each year. Patients usually die within five years of diagnosis. ALS occurs when specific nerve cells in the brain and spinal cord that control voluntary movement gradually degenerate. The loss of these motor neurons causes the muscles under their control to weaken and waste away, leading to paralysis. In some instances, the disease is inherited, but in most cases the cause is unknown.

But NIA scientists unearthed several new clues through a complex, multi-step investigation. After comparing spinal cord tissue extracted from people who had ALS with those who didn't, the investigators discovered that levels of ceramides, cholesterol esters and several other lipids were significantly elevated in the spinal cords of people with ALS.

To test whether these elevated levels of ce
'"/>

Contact: Doug Dollemore
dollemod@nia.nih.gov
301-496-1752
NIH/National Institute on Aging
21-Aug-2002


Page: 1 2 3

Related medicine news :

1. Release of results of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
2. Study suggests smoking while pregnant may increase chromosomal abnormalities in fetal cells
3. Depression predicts heart rhythm abnormalities in heart attack patients
4. New research brain abnormalities appear early in psychoses
5. Leptin replacement therapy reduces metabolic abnormalities in patients with rare fat disorders, researchers report
6. Researchers observe abnormalities in brains of autism patients
7. Estimated costs of treating abnormal fat distribution and metabolic abnormalities in HIV-infected individuals
8. Gene responsible for cerebral venous abnormalities found
9. New imaging method detects abnormalities in the brains tiny blood vessels
10. Study finds factors linked to substance use disorder relapse among health care professionals
11. Depression linked to insomnia in HIV patients

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Lipid abnormalities linked Lou Gehrigs disease

(Date:3/26/2015)... Elfster.com, the top-rated Secret Santa generator, is ... generator capabilities to its leading Secret Santa list technology. ... that one creates of things to do before one ... same name. Nowadays many millennials are creating summer ... achievements. , "We are greatly expanding our technology to ...
(Date:3/26/2015)... 26, 2015 North American Seminars launches ... is dedicated to providing information regarding OT PT continuing ... community. As a leader in live hands ... over 200 live and online continuing education courses. ... Courses :, A Master Clinicians Approach to Advanced Concepts ...
(Date:3/26/2015)... 26, 2015 Doctors Scott Sullivan and ... Breast Surgery (CRBS) and the St. Charles ... to announce that board certified Surgical Oncologist Dr. William ... surgeons. Ordoyne joins fellow breast surgical oncologist Alan Stolier, ... Frank DellaCroce, M.D., FACS; Scott Sullivan, M.D., FACS; Chris ...
(Date:3/26/2015)... NJ (PRWEB) March 26, 2015 ... statistical consulting firm, announced the release of BathroomMap® ... experts to increase access to public restrooms for travelers, ... in bathroom apps, BathroomMap does not facilitate a paid, ... algorithm to identify and rate local establishments that have ...
(Date:3/26/2015)... Md. (PRWEB) March 26, 2015 ... than $11.3 billion in 2014, according to an ... , The Annapolis-based healthcare real estate (HRE) data ... board members and two new Gold-Level Partners: Harrison ... Investment Services. , MOB transactions still going strong, ...
Breaking Medicine News(10 mins):Health News:Plans for Bucket List Generator - Just In Time for Summer - Announced by Elfster 2Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 2Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 3Health News:Surgical Oncologist Joins Center for Restorative Breast Surgery and St. Charles Surgical Hospital 2Health News:Surgical Oncologist Joins Center for Restorative Breast Surgery and St. Charles Surgical Hospital 3Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 2Health News:New Bathroom Finder App, BathroomMap®, Helps People with Medical Needs Who Urgently Need a Bathroom When Traveling 3Health News:Medical Real Estate Sales Topped $11.3 Billion in 2014 2Health News:Medical Real Estate Sales Topped $11.3 Billion in 2014 3Health News:Medical Real Estate Sales Topped $11.3 Billion in 2014 4
(Date:3/26/2015)... SANTA CLARA , Californie, 26 mars 2015 ... 2015, nouvel événement spécialement conçu pour les innovateurs, ... bio-traitement. Cette conférence d,une durée de ... au Hyatt Regency situé dans le centre ville ... 21 et 22 septembre 2015. Il s,agira d,un ...
(Date:3/26/2015)... and STAEFA, Switzerland , March 26, ... Venture platform, wirelessly transmits sound from the unaidable ear to ... This allows people with single-sided deafness to hear speech from ... fitting process for Phonak CROS II is as easy and ... experience the benefits of the CROS solution during the fitting ...
(Date:3/26/2015)... 2015 DePuy Synthes Companies has signed ... an emerging global leader in advanced medical imaging ... hip replacement systems. The agreement further demonstrates DePuy ... outcomes, increase patient satisfaction and reduce costs. The announcement ... meeting of the American Academy of Orthopaedic Surgeons ...
Breaking Medicine Technology:Finesse Solutions annonce l'événement Cellworld 2015 2Phonak CROS II: The smart solution for single-sided deafness 2DePuy Synthes Companies Announces Exclusive Agreement With Radlink To Help Address Key Challenges In Hip Replacement 2DePuy Synthes Companies Announces Exclusive Agreement With Radlink To Help Address Key Challenges In Hip Replacement 3
Cached News: