Lipid abnormalities linked to Lou Gehrigs disease

Abnormal accumulation of two common lipids in motor nerve cells could play a critical role in the development of amyotrophic lateral sclerosis (ALS), according to investigators at the National Institute on Aging (NIA) in Baltimore. The finding could help scientists develop drugs and other treatments that might one day slow or arrest the disease's progression.

"ALS is a terrible disease in which a fully functioning mind is trapped inside a body that is becoming progressively paralyzed. At the present time, nothing can be done for ALS, but we hope this newly established link between lipid regulation and the disease will hasten the development of new treatments," said Mark Mattson, Ph.D., lead author of the study* and chief of the NIA Laboratory of Neurosciences. Lipids are the building blocks of fats. The study is available online at the Annals of Neurology website, http://www3.interscience.wiley.com/ and will be published in the journal's September 2002 issue.

Also called Lou Gehrig's disease, ALS is a progressive, fatal neurological disease affecting as many as 20,000 Americans, with 5,000 new cases occurring in the United States each year. Patients usually die within five years of diagnosis. ALS occurs when specific nerve cells in the brain and spinal cord that control voluntary movement gradually degenerate. The loss of these motor neurons causes the muscles under their control to weaken and waste away, leading to paralysis. In some instances, the disease is inherited, but in most cases the cause is unknown.

But NIA scientists unearthed several new clues through a complex, multi-step investigation. After comparing spinal cord tissue extracted from people who had ALS with those who didn't, the investigators discovered that levels of ceramides, cholesterol esters and several other lipids were significantly elevated in the spinal cords of people with ALS.

To test whether these elevated levels of ce

Contact: Doug Dollemore
NIH/National Institute on Aging

Page: 1 2 3

Related medicine news :

1. Release of results of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
2. Study suggests smoking while pregnant may increase chromosomal abnormalities in fetal cells
3. Depression predicts heart rhythm abnormalities in heart attack patients
4. New research brain abnormalities appear early in psychoses
5. Leptin replacement therapy reduces metabolic abnormalities in patients with rare fat disorders, researchers report
6. Researchers observe abnormalities in brains of autism patients
7. Estimated costs of treating abnormal fat distribution and metabolic abnormalities in HIV-infected individuals
8. Gene responsible for cerebral venous abnormalities found
9. New imaging method detects abnormalities in the brains tiny blood vessels
10. Study finds factors linked to substance use disorder relapse among health care professionals
11. Depression linked to insomnia in HIV patients

Post Your Comments:
TAG: Lipid abnormalities linked Lou Gehrigs disease

(Date:12/24/2014)... Florida (PRWEB) December 24, 2014 The Healthy ... safer place to raise families. In-Vest USA ... who protect us – our first responders. Today, these two ... enforcement officers by providing them with body armor through In-Vest’s ... the tragic shootings that happened this past week in New ...
(Date:12/24/2014)... Verde Pointe Dental Associates 2014 Ugly Holiday ... years homemade Christmas sweater lit up, but this years overall ... is Tandy Wilson for the second year in a row. ... Kimmerling DDS. "She took pictures of the entire staff and ... , "Every year I enjoy stopping by the dental ...
(Date:12/24/2014)... 24, 2014 As 2014 draws to ... that before investing time and money into a new ... professional that specializes in tankless and eco-friendly products or ... their water heater in 2015 to research “green” and ... , Greenstar Home Services specializes in eco-friendly and ...
(Date:12/24/2014)... By Dennis Thompson ... -- There,s good news about the experimental Ebola vaccine that ... new research shows a precursor of that vaccine produced ... earlier version of the vaccine, when given to more than ... antibodies and white blood cells that could potentially protect a ...
(Date:12/24/2014)... Alan Mozes HealthDay Reporter TUESDAY, ... indoor tanning beds and booths, although this risky behavior remains popular ... reveals. In 2013, about 20 percent of high school girls ... form of indoor tanning at least once in the previous year, ... percent of girls and nearly 7 percent of boys who had ...
Breaking Medicine News(10 mins):Health News:The Healthy Home Company and In-Vest USA Team Up to Save the Lives of Law Enforcement 2Health News:Verde Pointe Dental Associates Announces the 2014 Ugly Sweater Holiday Contest Winner 2Health News:Greenstar Home Services Offers Tankless Water Heater Advice to Local Homeowners 2Health News:Early Study Offers Hope for an Ebola Vaccine 2Health News:Early Study Offers Hope for an Ebola Vaccine 3Health News:Early Study Offers Hope for an Ebola Vaccine 4Health News:Fewer U.S. Teens in Tanning Salons, Study Finds 2Health News:Fewer U.S. Teens in Tanning Salons, Study Finds 3
(Date:12/22/2014)... 22, 2014   TRU-D SmartUVC LLC, producers ... robot, announced today that the General Services Administration has ... 2019.   This newly formed agreement will ... of government purchasers, including Department of Veteran Affairs and ... Security contacts purchasing solutions for the Ebola effort in ...
(Date:12/22/2014)... , Dec. 22, 2014  ConvaTec, a privately-held ... Moraviec has been appointed Interim Chief Executive Officer of ... Moraviec succeeds Ken Berger .  "The Board of ... in leading ConvaTec over the past three years," said ... of Directors.  "We are confident that the company is ...
(Date:12/22/2014)... , Dec. 22, 2014 Swedish Orphan ... today announced that the Committee for Medicinal Products for ... has adopted a positive opinion for the use of ... men with Peyronie,s disease with a palpable plaque and ... start of therapy. The use of Xiapex ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
Cached News: