HOME >> MEDICINE >> NEWS
Lipid abnormalities linked to Lou Gehrigs disease

Abnormal accumulation of two common lipids in motor nerve cells could play a critical role in the development of amyotrophic lateral sclerosis (ALS), according to investigators at the National Institute on Aging (NIA) in Baltimore. The finding could help scientists develop drugs and other treatments that might one day slow or arrest the disease's progression.

"ALS is a terrible disease in which a fully functioning mind is trapped inside a body that is becoming progressively paralyzed. At the present time, nothing can be done for ALS, but we hope this newly established link between lipid regulation and the disease will hasten the development of new treatments," said Mark Mattson, Ph.D., lead author of the study* and chief of the NIA Laboratory of Neurosciences. Lipids are the building blocks of fats. The study is available online at the Annals of Neurology website, http://www3.interscience.wiley.com/ and will be published in the journal's September 2002 issue.

Also called Lou Gehrig's disease, ALS is a progressive, fatal neurological disease affecting as many as 20,000 Americans, with 5,000 new cases occurring in the United States each year. Patients usually die within five years of diagnosis. ALS occurs when specific nerve cells in the brain and spinal cord that control voluntary movement gradually degenerate. The loss of these motor neurons causes the muscles under their control to weaken and waste away, leading to paralysis. In some instances, the disease is inherited, but in most cases the cause is unknown.

But NIA scientists unearthed several new clues through a complex, multi-step investigation. After comparing spinal cord tissue extracted from people who had ALS with those who didn't, the investigators discovered that levels of ceramides, cholesterol esters and several other lipids were significantly elevated in the spinal cords of people with ALS.

To test whether these elevated levels of ce
'"/>

Contact: Doug Dollemore
dollemod@nia.nih.gov
301-496-1752
NIH/National Institute on Aging
21-Aug-2002


Page: 1 2 3

Related medicine news :

1. Release of results of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
2. Study suggests smoking while pregnant may increase chromosomal abnormalities in fetal cells
3. Depression predicts heart rhythm abnormalities in heart attack patients
4. New research brain abnormalities appear early in psychoses
5. Leptin replacement therapy reduces metabolic abnormalities in patients with rare fat disorders, researchers report
6. Researchers observe abnormalities in brains of autism patients
7. Estimated costs of treating abnormal fat distribution and metabolic abnormalities in HIV-infected individuals
8. Gene responsible for cerebral venous abnormalities found
9. New imaging method detects abnormalities in the brains tiny blood vessels
10. Study finds factors linked to substance use disorder relapse among health care professionals
11. Depression linked to insomnia in HIV patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... ... ... “Reflections of God’s Work”: an enlightening collection of life lessons leading each person to ... Jerri Broglin, a survivor of great loss who gained insight on how to find ... searching for answers, as we are finding the answers that are so deep in ...
(Date:4/24/2017)... ... , ... Life of Purpose Treatment is proud to present “An Evening for ... 7:30 pm on May 10th at the University Auditorium. , This benefit concert, featuring ... the UF Collegiate Recovery Community (UFCRC). The concert will kick off the 5th Annual ...
(Date:4/23/2017)... ... April 23, 2017 , ... "An event Horizon is a ... process rendered in my Art and Music. These are created as Metaphysical Transformations where ... boundary of mystery culminate to the ultimate singularity.", -- Karen Salicath Jamali , Karen ...
(Date:4/22/2017)... ... 22, 2017 , ... PharmacyChecker.com released its first International Prescription ... 70% when buying medication online from Canadian pharmacies verified in the PharmacyChecker Verification ... countries. The report (chart below) compares U.S. and foreign prices for 20 of ...
(Date:4/21/2017)... ... 21, 2017 , ... Providing broad access to life-saving drugs and rewarding the ... better way to address this problem. , That was the message from Dana Goldman, ... at the University of Southern California, who served as the keynote speaker for Western ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 2017 Research and Markets has announced the ... by Rapidly Expanding Injectables Market and Increasing Usage of Complex Biologics ... ... will rise from USD 20 Billion in 2015 to around USD ... Technologies - Innovation Driven by Rapidly Expanding Injectables Market and Increasing ...
(Date:4/20/2017)... , April 20, 2017  AbbVie (NYSE: ABBV), ... percent (n=145/146) of chronic hepatitis C virus (HCV) ... or 6 and compensated cirrhosis (Child-Pugh A) achieved ... 12 ) with its investigational, pan-genotypic regimen of ... were seen following 12 weeks of G/P treatment ...
(Date:4/20/2017)... LUND, Sweden , April 20, 2017 /PRNewswire/ ... OTCQX: NEVPF) ("NeuroVive") today announced positive preclinical ... company,s preclinical compound for non-alcoholic steatohepatitis (NASH), ... NV556 has previously ... STAM™ NASH model. Today, NeuroVive,s scientists present ...
Breaking Medicine Technology:
Cached News: