Lithium may protect neurons from radiation therapy

NASHVILLE, Tenn. (Oct. 8, 2004) -- Patients who undergo radiation for treatment of brain tumors may survive their cancer only to have lasting memory and learning deficiencies, the impact of which can be particularly devastating for children.

Now, researchers at the Vanderbilt-Ingram Cancer Center have discovered that lithium, a drug commonly used to treat bipolar disorder and other mental illnesses, can protect the brain cells involved in learning and memory from radiation damage.

While the work has been conducted in cell culture and animal studies thus far, clinical trials are expected to be conducted soon to test whether the drug can protect humans from cognitive deficits as a result of cranial radiation therapy.

The researchers presented their work during the 46th annual meeting of the American Society for Therapeutic Radiology and Oncology, earlier this week in Atlanta.

"In addition to killing cancer cells, radiation can cause cell death apoptosis in normal cells as well," said Dennis Hallahan, M.D., professor and chair of Radiation Oncology at Vanderbilt University School of Medicine in Nashville, Tenn. "Particularly susceptible are neurons in the hippocampus, the part of the brain that plays a crucial role in learning and memory."

Lithium is an inhibitor of a protein that causes apoptosis called glycogen synthase kinase 3 b. Studies suggest that it may protect neurons from a variety of cytotoxic insults, including observations that the incidence of Alzheimer's disease which leads to progressive and profound memory loss is lower among patients who take lithium for mental illness, Hallahan said.

The researchers observed in animal models that a single radiation dose of 5 Gy caused a massive amount of apoptosis in the hippocampus but not in other areas of the brain.

However, treatment of a mouse hippocampus cell with lithium for a week prior to 3 Gy of radiation resulted in a 60 percent increase in cell survival; a week'

Contact: Cynthia Floyd Manley
Vanderbilt University Medical Center

Page: 1 2

Related medicine news :

1. Conference Celebrates Lithiums 50 Years As A Miracle Drug
2. UK Allied Health Professor Receives Patent On Using Lithium With AIDS Drugs
3. Research Explains Lithiums Dual Anti-Manic/Anti-Depressive Effect
4. New study in Nature demonstrates protection against cell death during heart attack
5. Simple intervention encourages sun protection behaviors
6. Red wine protects the heart
7. Sunflower seed oil can protect low birth weight babies from infection
8. Physical activity linked to protection from Parkinsons disease
9. Component of green tea protects injured livers in mice
10. Study shows protective equipment not very effective for rugby players
11. Least protection offered to those most at risk of sudden cardiac death

Post Your Comments:

(Date:10/10/2015)... ... October 10, 2015 , ... With the winter season coming close, the need for additional ... Cozy Products is familiar with the problem and discusses the issue. , “Don’t use ... inside of the chicken coop in the winter, utilize a safe heat source such as ...
(Date:10/10/2015)... ... ... walk with crutches for the rest of my life," said an inventor from San Diego, ... give me more independence and freedom would be amazing. This inspired me to invent a ... STRAP IN to enable an individual to walk with crutches without having to use his ...
(Date:10/10/2015)... ... October 10, 2015 , ... The sixth annual cost ... the growth of cybercrime costs for US companies. The New York Times broke down ... With averages showing increases hovering around 20% among the companies surveyed, it only proves ...
(Date:10/10/2015)... (PRWEB) , ... October 10, 2015 , ... The Bank ... Speedway in Concord, NC. Saturday, October 10th, defending race winner, Kevin Harvick, ... Logano, Matt Kenseth, Dale Earnhardt Jr., and all of the stars of the NASCAR ...
(Date:10/10/2015)... ... October 10, 2015 , ... Story Chaser is ... works by reading various classics and inspiring stories and as words drop down and ... The animations are extremely aesthetic and can be interacted with, making it a more ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... 2015 Adheron Therapeutics, a privately held ... , United States , ... acquired by Roche.  Adheron Therapeutics has developed a ... a cell surface protein called Cadherin-11 in order ... inflammatory and autoimmune diseases such as rheumatoid arthritis ...
(Date:10/9/2015)...   --> --> ... San Diego, California , by Dr. Tom Lyon ... Medical Center, on 9 th October 2015 at 8:30a.m. PDT. ... Tom Lyon , Director of Orthopaedics and Chief of Orthopaedic ... at 8:30a.m. PDT. --> Kuros Biosurgery AG, a biotechnology ...
(Date:10/9/2015)... , Schweiz, October 9, 2015 Der ... Dr.   Yutaka Kondo und Dr.   Junko Takita ...   2015 " geht an Dr.   Yutaka ... Der " JCA-Mauvernay Award   2015 ... Dr.   Junko Takita    ™ , das ...
Breaking Medicine Technology:
Cached News: