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Long-term benefits found in two drugs for Parkinson's

duced (from 37 to 19 percent). During the 36 months of observation, the mortality rate for the group was 52 percent for outpatients and 62 percent for nursing home residents.

This mortality rate is somewhat higher than the estimated general mortality rate of 36 percent for all PD patients after 13 years of illness. However, this mortality rate is lower than the mortality rate of 80 percent reported prior to 1996 for patients with PD and hallucinations residing in nursing homes and treated with typical antipsychotics. By the end of the 36-month follow-up, 50 percent of hallucinating PD patients had been placed in nursing homes. That number was a significant improvement from the 80 percent reported by others before 1996.

"These preliminary results support the view that quetiapine and clozapine may have long-term benefits in PD patients with hallucinations," Dr. Juncos says. "This benefit may translate into reduced mortality and a reduced risk of nursing home placement."


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Contact: Janet Christenbury
jmchris@emory.edu
404-727-8599
Emory University Health Sciences Center
18-Apr-2002


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