Long-term data show benefit of DETROL LA as first-line therapy for overacti...( New York December 13 2004 Pfizer Inc...),Health

New York, December 13, 2004 Pfizer Inc today announced results of a comprehensive six-year review of efficacy and safety data for DETROL LA (tolterodine tartrate extended release capsules) indicating that DETROL LA significantly reduces symptoms of overactive bladder (OAB) with a low occurrence of side effects, and should be considered first-line therapy. The results were recently published in the journal Drug Safety.

An estimated 33 million Americans over the age of 18 suffer from OAB, a medical condition which studies have found disrupts daily activities and sleep, and can negatively impact patients' mental health.

"We know that OAB is an important medical condition that can dramatically impact quality of life for some sufferers. Yet many are resigned to coping with their symptoms or concerned about bothersome treatment side effects," said lead study author Dr. Alan D. Garely, Winthrop University Hospital, Mineola, New York. "This six year review is good news for people with OAB because it shows that DETROL LA can significantly reduce symptoms with a low frequency of side effects. This may contribute to greater patient satisfaction with treatment, resulting in patients staying on treatment longer."

The meta-analysis summarized worldwide clinical trial and postmarketing surveillance data collected during a six-year period, from January 1,1997 to March 2003, in the 100 countries where DETROL LA is approved for use. In 26 clinical studies, DETROL LA was found to significantly reduce OAB symptoms, including frequency, urgency and number of episodes of urge incontinence. In the two largest trials, the number of incontinence episodes was approximately halved and incontinence pad usage was decreased by more than a third. Disruption of daily activities was also shown to improve with DETROL LA across several health-related quality of life measures, including physical limitations, sleep and energy. Dry mouth was the most commonly reported ad
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13-Dec-2004

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