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Long-term data show benefit of DETROL LA as first-line therapy for overactive bladder

verse event associated with DETROL LA, and most cases were mild to moderate.

The safety profile of DETROL LA in adults aged 65 and older is similar to that in younger adults. Unlike other OAB medications, DETROL LA is not associated with a high incidence of constipation, which can significantly impact patients' quality of life and develop into more serious bowel conditions. The incidence of constipation with DETROL LA was reported by 2 percent to 7 percent of patients versus 4 percent reported by those receiving placebo. Serious adverse events (affecting the gastrointestinal tract, nervous system and cardiovascular system) are reported infrequently in patients treated with DETROL LA.

About OAB OAB a medical condition associated with involuntary contractions of the bladder muscle. A person with OAB will feel a sudden and sometimes overwhelming urge to urinate (urgency). This is because the bladder muscle squeezes or contracts at a small volume and without the normal warning signals that capacity is being reached. This usually results in more frequent urination (frequency), and sometimes, wetting accidents (urge incontinence).

Treatment

Once OAB is diagnosed, muscarinic receptor antagonists, the mainstay of medical treatment for OAB, may be prescribed. One such medication, DETROL LA, works by helping to control involuntary contractions of the bladder muscle. Behavioral techniques such as pelvic floor muscle exercises, or bladder training may provide additional benefit to the medication by helping the patient reassert control over his or her bladder.

About DETROL LA

DETROL LA is a once-daily medication with proven efficacy for 24 hours to help control involuntary bladder contractions and reduce wetting accidents. By reducing the number and intensity of involuntary bladder muscle contractions, DETROL LA also reduces the strong sensation of urinary urgency and the number of voiding ep
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13-Dec-2004


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