HOME >> MEDICINE >> NEWS
Long-term effects of tirofiban similar to abciximab in patients having coronary-artery angioplasty

A follow-up study in this week's issue of THE LANCET helps to clarify the differences between two similar drugs in terms of their benefits for patients who undergo angioplasty for narrowed coronary arteries (the arteries that supply the heart with blood).

Platelet glycoprotein IIb/IIIa inhibitors reduce the clumping together of platelets in the blood, which can lead to complications during procedures to open narrowed arteries. Tirofiban and abciximab are two such drugs, but each blocks platelet clumping in a slightly different way. Researchers around the world are trying to work out the relevance of these differences with respect to patients' health. Last year, the TARGET investigators showed that abciximab was significantly better than tirofiban at preventing death, heart attacks, and repeated surgery among 4809 patients within 30 days after they had undergone a coronary-artery angioplasty with stent placement.

These investigators, led by Dr David Moliterno from the Cleveland Clinic Foundation, Ohio, USA, now report follow-up data from the TARGET study, which they obtained 6 months after angioplasty. Surprisingly, they found that 148% of the patients taking tirofiban had died, had a heart attack, or had repeat surgery, compared with 143% of those who took abciximab. In other words, the drugs were about equally effective in terms of preventing these longer-term events.

David Moliterno comments: "As studied, abciximab was more protective against a heart attack occurring during, or immediately following, angioplasty. Yet the two drugs were associated with similarly low rates of death and renarrowing of the heart's arteries at 6 months. Our conclusion is that while the more expensive drug (abciximab) is better 'up front', it provides little long-term advantage compared with tirofiban."


'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-20-7424-4949
Lancet
1-Aug-2002


Page: 1

Related medicine news :

1. Long-term high consumption of red and processed meat linked with increased risk for colon cancer
2. Long-term data show benefit of DETROL LA as first-line therapy for overactive bladder
3. Long-term benefits for newly diagnosed patients with CML receiving first-line therapy with imatinib
4. Long-term obesity linked to loss of brain tissue in women
5. Long-term study demonstrated ADDERALL XR is an effective option to treat adolescents with ADHA
6. Long-term study proves ADDERALL XR is a safe and effective option to treat adults with ADHD
7. Long-term use of antibiotics possibly linked with increased risk of breast cancer
8. Long-term follow-up of mortality in patients with community-acquired pneumonia
9. Long-term outcome of epilepsy surgery is favorable for many
10. Long-term ERT in postmenopausal women with Alzheimers may worsen memory
11. Long-term avoidance of milk in children results in poor bone health

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... ST. LOUIS (PRWEB) , ... February 13, 2019 ... ... on May 13, 2019, at the company’s annual member conference, Elevate 2019 at ... to key Intalere staff and members to explore potential partnerships driving improved quality ...
(Date:2/13/2019)... ... 13, 2019 , ... American Vision Partners, one of the ... a new addition to their growing list of ophthalmology brands: Visage Aesthetics & ... ophthalmology practice. , Dr. Zachary Berbos, MD, FACS, and Dr. Grant ...
(Date:2/13/2019)... ... ... Asana Recovery is accepting applications from college-bound or current college students for ... of study in California, the $1,000 scholarship will be awarded to a student who ... how it has led them to their chosen field of study. Applications for the ...
(Date:2/12/2019)... ... February 12, 2019 , ... Medical Device ... and Ombu Enterprises**, Feb. 19-20, 2019, Atlanta, GA , https://www.fdanews.com/mdriskmanagement , ... Winds of Change on Jan. 22 , Risk management is just plain hard, ...
(Date:2/11/2019)... EDISON, N.J. (PRWEB) , ... February 11, 2019 ... ... workforce management capabilities to SmartLinx Solutions because the integrated suite could ... A former Kronos Workforce Ready, Time Systems International, and Paycom client, Caring Health ...
Breaking Medicine News(10 mins):
(Date:2/16/2019)... NASHVILLE, Tenn. (PRWEB) , ... February 15, 2019 ... ... Tennessee market, has joined the esteemed Haute Beauty network. , The Haute Beauty ... Dr. Bryant as a leading Face expert and our newest addition ...
(Date:2/16/2019)... DENVILLE, N.J. (PRWEB) , ... February 15, 2019 ... ... its opening in Denville, NJ. Created by recognized physicians in urology, COR Medspa ... and sexual wellness treatments on the market. , COR stands for Center ...
(Date:2/14/2019)... ... 2019 , ... Shady Grove Fertility Atlanta (SGF Atlanta) ... has been named Medical Director for the Atlanta region. This distinction is based ... Atlanta community in helping patients overcome infertility. In this role, Dr. McCarthy-Keith will ...
Breaking Medicine Technology:
Cached News: