HOME >> MEDICINE >> NEWS
Longevity gene may also predict better outcome for breast cancer patients

HOUSTON - A gene known to promote longevity in animals has now been discovered to encode a tumor suppressor - a protein that helps prevent cancer, according to a study by a team of scientists from The University of Texas M. D. Anderson Cancer Center. The new gene, which was inactivated in two-thirds of patients studied, presents a potent new target for breast cancer therapy, the researchers say.

In a study published in the April 16, 2004, issue of the journal Cell, scientists describe how the presence of the protein, named Forkhead box class O3 (FOXO3), is associated with better outcomes for breast cancer patients. Conversely, if FOXO3 was inactivated, patients had worse outcomes.

"This is a very good prognostic marker for breast cancer patient outcome," said Mien-Chie Hung, Ph.D., the co-principal investigator of the study. "In addition, these proteins provide new targets for cancer therapy and prevention."

The research team, which was a collaboration between the laboratories of Mickey C.-T. Hu, Ph.D., and Hung, both of the Department of Molecular and Cellular Oncology at M. D. Anderson, demonstrated that FOXO3 is inactivated in many cancer patients by an enzyme called IKK and determined that IKK is an oncoprotein, a protein that can induce cancer.

"We have uncovered two important events and put them together in one story," says Hung. "This research has identified an important new tumor suppressor protein and a new oncogene that provide targets for cancer therapy. Previously, these proteins had been suspected to be involved in cancer, but there was no direct evidence for that."

The IKK oncoprotein belongs to a family of enzymes called kinases. Researchers have shown that blocking certain kinases can be an effective way to block cancer. New generation cancer drugs such as Gleevec, which has been effective in treating leukemia patients, work by zeroing in and inactivating a kinase molecule. S
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
15-Apr-2004


Page: 1 2

Related medicine news :

1. Research Shows Religion Plays A Major Role In Health, Longevity
2. Research Links Healthy Biological Clock To Longevity
3. UI Study Finds Social Support May Increase Longevity Of People With Schizophrenia
4. New evaluation tool reliably predicts recovery from coma
5. Oral bacteria may predict pregnancy outcomes
6. Explosion of child obesity predicted to shorten us life expectancy
7. Simple blood test may help to predict cardiovascular risk in older women
8. New scale predicts recovery of consciousness from coma after brain injury
9. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
10. Serum sodium level is a major predictor of a poor prognosis for heart failure patients
11. Depression predicts heart rhythm abnormalities in heart attack patients

Post Your Comments:
(Date:10/20/2014)... New York, NY (PRWEB) October 20, 2014 ... City based non-profit organization that helps New Yorkers ... lasting, positive changes toward health, housing, recovery and ... who have transformed the local community through their ... Managing Director, Marc Shapses , has been ...
(Date:10/20/2014)... hc1.com today announced the launch of ... enables healthcare organizations of all sizes to immediately ... management (“CRM”) solution. , Designed from the ground ... healthcare industry, the hc1 Healthcare Relationship Cloud™ personalizes ... combining healthcare CRM, HIPAA-compliant collaboration, and real-time analytics ...
(Date:10/20/2014)... WA (PRWEB) October 20, 2014 My ... workflow management software application. The new module enables ... patients receive full life-cycle quality care. , This application ... others within their practice, attach a to-do item to ... fit, and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... October 20, 2014 Myoderm ... as Assistant Director of their CentralSource ... managing the innovative turnkey drug sourcing, distribution, and ... brings over 12 years of industry experience, in ... at the peak of their international success to ...
(Date:10/20/2014)... Fort Collins, CO (PRWEB) October 20, 2014 ... platform, dGH assays are the only imaging assays ... data in a single test.  With these three ... in their ability to detect the widest range ... chromosomal translocations—mutations usually missed by other genomic tools, ...
Breaking Medicine News(10 mins):Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3
(Date:10/17/2014)... 2014  Training market researchers to spot and ... in today,s highly competitive global marketplace. As resources ... effectively and efficiently produce high performing analysts, regardless ... Effective training programs can help these ... internal clients by developing analysts who can drive ...
(Date:10/17/2014)... -- Research and Markets  has announced the ... of China Dialysis Market, 2014-2018" report to ... 2013 version, this update Report provides detailed analysis ... the relevant effect in recent three years, and ... it analyzes Chinese private-owned hemodialysis services. In the ...
(Date:10/17/2014)... BALTIMORE, Md. , Oct. 17, 2014 /PRNewswire-USNewswire/ ... Center for Medical Technology Policy: The ... from the FDA, public and private payers, medical ... representatives, clinicians, and other experts January 12, 2015 ... effectiveness and value of weight loss treatments.  Participants ...
Breaking Medicine Technology:Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
Cached News: