HOME >> MEDICINE >> NEWS
Longterm immune memory cells cells do not develop during chronic viral infections

Immune T cells that respond to chronic viral infections do not acquire the same "memory" capabilities of T cells that respond to acute viral infections, according to research by scientists at Emory University. The finding may explain why people lose their immunity to some viruses after chronic infections are controlled. It could guide scientists in developing better therapeutic combinations of antiviral therapies and therapeutic vaccines. The research is published online in the Proceedings of the National Academy of Sciences.

Lead author of the study is E. John Wherry, PhD, postdoctoral fellow in the Department of Microbiology and Immunology at Emory University School of Medicine and the Emory Vaccine Center. Senior author is Rafi Ahmed, PhD, director of the Emory Vaccine Center, Georgia Research Alliance Eminent Scholar, and professor of microbiology and immunology.

The immune system responds to viral infections in two ways: with antibodies that help prevent viruses from entering cells and with T cells activated in response to viral antigens. T cells kill the virus-infected cells and produce proteins called cytokines that prevent the growth of viruses and make cells resistant to viral infection. During the acute phase of a viral infection, activated CD8 T cells respond aggressively for a few weeks, then about five percent of them become "memory cells" that maintain a stable memory T cell population by slow, steady turnover. These memory cells are poised to mount an even stronger and more rapid response to future attacks by the same virus. Individuals who acquire immunity to diseases such as measles, yellow fever, smallpox, or polio, either through exposure or vaccination, often are capable of retaining that immunity for many years or for an entire lifetime.

Dr. Ahmed and his colleagues discovered in previous research that following acute viral infections, immune memory CD8 T cells continue to maintain their ability to attack viruses even
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
5-Nov-2004


Page: 1 2 3 4

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
3. Smart immune cells kill more cancer
4. New network of gastrointestinal immune cells discovered
5. Old T cells cripple immune function in the elderly
6. Novel p53 gene-based therapy boosts immune system and reduces tumor size
7. VGTI researchers help uncover why aging reduces immune system function
8. Brains immune system triggered in autism
9. Marine sponge leads researchers to immune system regulator
10. Mayo Clinic discovers one mechanism for why men and women differ in immune response
11. Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response

Post Your Comments:
(Date:11/26/2014)... (PRWEB) November 26, 2014 The ... submissions for the tenth annual MEDA Awards, which, ... development excellence in Maryland. “The MEDA Awards recognize ... prosperity to the state. We encourage our members ... are making a positive economic impact in the ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 Increasing ... which include image guided surgeries has paved way ... injectors. Rising incidence of various types of cancers ... proportionate increase in demand for these owing to ... of contrast media injectors market can also be ...
(Date:11/26/2014)... German scientists say carbon-based synthetic molecules ... mesothelioma that looks and acts similar to asbestos-induced mesothelioma. ... the research. Click here to read it now. ... and Experimental Medicine in Hannover injected 500 lab rats ... rats eventually developed mesothelioma , how quickly it ...
(Date:11/26/2014)... November 26, 2014 For its ... published The AIS Report on Blue Cross and Blue ... Inc. on the varied strategies the two Blues plans ... compliance with treatments for sleep apnea, ranging from brick-and-mortar ... because it’s linked to increased rates of a variety ...
(Date:11/26/2014)... 26, 2014 With Thousand Oaks cosmetic ... the prosthodontists at the Anacapa Dental Art Institute in Woodland ... can be daunting for some. , That is why they ... they offer. , “No dentist wants cost to come between ... teeth,” said Dr. Mamaly Reshad, partner in the Anacapa Dental ...
Breaking Medicine News(10 mins):Health News:Maryland Economic Development Association Seeking Submissions for 2015 Awards 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3Health News:Multi-walled Nanotubes Linked to Mesothelioma in New Study, According to Surviving Mesothelioma 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 2Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 3Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 4Health News:Anacapa Dental Art Institute Doctors Offers 6 Tips on How to Pay for Cosmetic, Restorative and Implant Dentistry 5
(Date:11/24/2014)... - Milestone Pharmaceuticals, Inc. today announced data from a Phase ... Australia of MSP-2017, a novel calcium ... supraventricular tachycardia (PSVT).  The results demonstrated that an ... single doses up to and including 140 mg ... including rapid onset, and validating proof of concept ...
(Date:11/24/2014)... Fla. , Nov. 24, 2014  Marta Rendon, MD, ... Boca Raton , FL and international key opinion ... selected from the United States to ... Istanbul, Turkey . Here, at this gathering ... West, as world renowned facial plastic surgery experts from ...
(Date:11/24/2014)... The Female Health Company (NASDAQ-CM: FHCO), today announced that ... its operating results for the fourth quarter and fiscal ... 2014 at 11:00 a.m. Eastern Standard Time (EST).  The ... same day. Shareholders and other interested parties ... (international participants dial 1-412-317-6716) and asking to be connected ...
Breaking Medicine Technology:Milestone Announces Positive Phase 1 Data for MSP-2017; Supports Advancement into Phase 2 in PSVT Patients 2Milestone Announces Positive Phase 1 Data for MSP-2017; Supports Advancement into Phase 2 in PSVT Patients 3Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 2Marta Rendon, MD Selected To Attend Prestigious, Global Aesthetic Experts Summit! 3The Female Health Company To Report FY2014 Operating Results on Tuesday, December 2, 2014 2
Cached News: