HOME >> MEDICINE >> NEWS
Longterm immune memory cells cells do not develop during chronic viral infections

Immune T cells that respond to chronic viral infections do not acquire the same "memory" capabilities of T cells that respond to acute viral infections, according to research by scientists at Emory University. The finding may explain why people lose their immunity to some viruses after chronic infections are controlled. It could guide scientists in developing better therapeutic combinations of antiviral therapies and therapeutic vaccines. The research is published online in the Proceedings of the National Academy of Sciences.

Lead author of the study is E. John Wherry, PhD, postdoctoral fellow in the Department of Microbiology and Immunology at Emory University School of Medicine and the Emory Vaccine Center. Senior author is Rafi Ahmed, PhD, director of the Emory Vaccine Center, Georgia Research Alliance Eminent Scholar, and professor of microbiology and immunology.

The immune system responds to viral infections in two ways: with antibodies that help prevent viruses from entering cells and with T cells activated in response to viral antigens. T cells kill the virus-infected cells and produce proteins called cytokines that prevent the growth of viruses and make cells resistant to viral infection. During the acute phase of a viral infection, activated CD8 T cells respond aggressively for a few weeks, then about five percent of them become "memory cells" that maintain a stable memory T cell population by slow, steady turnover. These memory cells are poised to mount an even stronger and more rapid response to future attacks by the same virus. Individuals who acquire immunity to diseases such as measles, yellow fever, smallpox, or polio, either through exposure or vaccination, often are capable of retaining that immunity for many years or for an entire lifetime.

Dr. Ahmed and his colleagues discovered in previous research that following acute viral infections, immune memory CD8 T cells continue to maintain their ability to attack viruses even
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
5-Nov-2004


Page: 1 2 3 4

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
3. Smart immune cells kill more cancer
4. New network of gastrointestinal immune cells discovered
5. Old T cells cripple immune function in the elderly
6. Novel p53 gene-based therapy boosts immune system and reduces tumor size
7. VGTI researchers help uncover why aging reduces immune system function
8. Brains immune system triggered in autism
9. Marine sponge leads researchers to immune system regulator
10. Mayo Clinic discovers one mechanism for why men and women differ in immune response
11. Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... ... , ... Gevir, a New Zealand-based company that focuses on developing powder and ... to Amazon.com, the world’s largest online retailer. , The company was founded ... natural treatment for Shelley’s Multiple Sclerosis, which she’d been diagnosed with at 28 years ...
(Date:2/22/2017)... ... February 22, 2017 , ... The ... eligibility requirements effective with the April 2017 testing period. NACCM, a nonprofit organization, ... Care Manager Certified (CMC) exam is periodically re-calibrated to ensure that newly certified ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... conditions reported skipping doses or not filling a prescription because they could not ... of cost-related problems getting medications were 30-60%*. At the same time, ...
(Date:2/22/2017)... ... February 22, 2017 , ... THR ... “NANOCALM 300” Microemulsified Hemp Extract. This premier nanoemulsified CBD product utilizes Quicksilver ... the bloodstream. Far outpacing the absorption speed of all other products, ...
(Date:2/22/2017)... ... February 22, 2017 , ... The ... Insights to help small practices in Delaware, New Jersey, Pennsylvania and West Virginia ... Medicare Access and CHIP Reauthorization Act of 2015 (MACRA). , This technical ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... The fast-growing cannabis market is expected ... . According to the 2017 Legal Marijuana Outlook, published ... create 283,422 jobs by 2020, with an implied growth rate ... years. The accelerating pace of cannabis legalization is considered as ... market, which will further create more business ventures and boost ...
(Date:2/23/2017)... February 23, 2017 The top ... are GE Healthcare, Koninklijke Philips N.V., and Schiller. Collectively, ... the global market in 2015. Strong product portfolio and ... assessed to be aiding these players remain leaders in ... the players in the global market are likely to ...
(Date:2/23/2017)... Feb. 23, 2017   SeraCare Life Sciences ... in vitro diagnostics manufacturers and clinical laboratories, is ... Implementation of NGS-Based Tests" to be hosted by ... at 11am Eastern Standard Time (US). ... the need for improved performance and global standardization ...
Breaking Medicine Technology:
Cached News: