HOME >> MEDICINE >> NEWS
Longterm immune memory cells cells do not develop during chronic viral infections

Immune T cells that respond to chronic viral infections do not acquire the same "memory" capabilities of T cells that respond to acute viral infections, according to research by scientists at Emory University. The finding may explain why people lose their immunity to some viruses after chronic infections are controlled. It could guide scientists in developing better therapeutic combinations of antiviral therapies and therapeutic vaccines. The research is published online in the Proceedings of the National Academy of Sciences.

Lead author of the study is E. John Wherry, PhD, postdoctoral fellow in the Department of Microbiology and Immunology at Emory University School of Medicine and the Emory Vaccine Center. Senior author is Rafi Ahmed, PhD, director of the Emory Vaccine Center, Georgia Research Alliance Eminent Scholar, and professor of microbiology and immunology.

The immune system responds to viral infections in two ways: with antibodies that help prevent viruses from entering cells and with T cells activated in response to viral antigens. T cells kill the virus-infected cells and produce proteins called cytokines that prevent the growth of viruses and make cells resistant to viral infection. During the acute phase of a viral infection, activated CD8 T cells respond aggressively for a few weeks, then about five percent of them become "memory cells" that maintain a stable memory T cell population by slow, steady turnover. These memory cells are poised to mount an even stronger and more rapid response to future attacks by the same virus. Individuals who acquire immunity to diseases such as measles, yellow fever, smallpox, or polio, either through exposure or vaccination, often are capable of retaining that immunity for many years or for an entire lifetime.

Dr. Ahmed and his colleagues discovered in previous research that following acute viral infections, immune memory CD8 T cells continue to maintain their ability to attack viruses even
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
5-Nov-2004


Page: 1 2 3 4

Related medicine news :

1. Chemists identify immune system mechanism for methamphetamine binges
2. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
3. Smart immune cells kill more cancer
4. New network of gastrointestinal immune cells discovered
5. Old T cells cripple immune function in the elderly
6. Novel p53 gene-based therapy boosts immune system and reduces tumor size
7. VGTI researchers help uncover why aging reduces immune system function
8. Brains immune system triggered in autism
9. Marine sponge leads researchers to immune system regulator
10. Mayo Clinic discovers one mechanism for why men and women differ in immune response
11. Lab study defines and blocks mechanism that lets brain tumors sidetrack immune response

Post Your Comments:
(Date:4/18/2014)... lead to potential new treatments for breaking the cycle ... Fibrosis, or scarring, is a hallmark of the disease, ... lead to serious organ damage and, in some cases, ... on findings made by Swati Bhattacharyya, PhD, research assistant ... specific protein plays in promoting fibrosis. , "Our ...
(Date:4/17/2014)... most popular vaccine brands for children may not be ... some cost factors when choosing vaccines, driving the market ... to a new study by University of Illinois researchers. ... driven by numerous factors," says Sheldon H. Jacobson, a ... science and of mathematics at the U. of I. ...
(Date:4/17/2014)... published in the April issue of Immunity , ... for Medical Research, says it,s time to take a ... treating sepsis, which kills millions worldwide every year, ... molecules released into the bloodstream to fight an injury ... necessary for maintaining good health without inflammation, wounds ...
(Date:4/17/2014)... that as many as 10 million older Americans suffer ... and isolation. , However, new research a project ... Americans for six years found that Internet use ... by more than 30 percent. , "That,s a very ... professor of telecommunication, information studies and media who led ...
(Date:4/17/2014)... EcoHealth Alliance, a nonprofit organization that focuses on ... review today examining the current state of knowledge of ... for improved global surveillance strategies to combat the emergence ... Ebola in West Africa that has claimed the lives ... Liberia. According to the World Health Organization (WHO), ...
Breaking Medicine News(10 mins):Health News:New clues on tissue scarring in scleroderma 2Health News:Study recalculates costs of combination vaccines 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Internet use can help ward off depression among elderly 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3
(Date:1/15/2014)... , Jan. 15, 2014  Humberto C. Antunes,  Galderma  worldwide ... from the Journal of Drugs in Dermatology ... Conference (ODAC). The event is January 17-20, 2014, at the Omni ... . The ODAC is a distinguished ...
(Date:1/15/2014)... , Jan. 15, 2014  In an unprecedented effort to curb ... in ambulances and other transport vehicles, an advanced and portable UV ... personnel for the first time. In order to ... these deadly pathogens, West Palm Beach Fire ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Superbugs No Longer Ride In Rescue Vehicles 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
Cached News: