HOME >> MEDICINE >> NEWS
Low-dose aspirin and stomach ulcer medications better for heart patients with GI complications

DALLAS Jan. 20, 2005 Heart patients with gastrointestinal complications should use low doses of aspirin combined with drugs that treat stomach ulcers rather than taking the anti-platelet drug Plavix, which has been thought to reduce bleeding ulcers, according to a gastroenterologist at UT Southwestern Medical Center and the Dallas Veterans Affairs Medical Center.

Physicians are challenged in treating heart patients who may be at high-risk for gastrointestinal bleeding from aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Factors that place patients at high-risk include a history of ulcers or gastrointestinal complications such as bleeding, increased age and congestive heart failure.

Low-dose aspirin (325 milligrams or less daily) has been shown to lower the risk of cardiovascular and cerebrovascular blood clots. It can, however, cause gastrointestinal ulceration and major bleeding, thereby limiting its overall usefulness even at the lowest effective amount. In an editorial in the current issue of The New England Journal of Medicine, Dr. Byron Cryer, associate professor of internal medicine at UT Southwestern, said current cardiology guidelines suggest patients who cannot take aspirin because of previous bleeding ulcers be given the drug clopidogrel (Plavix), which has been found to be marginally better than low-dose aspirin in preventing heart attacks and reducing bleeding ulcers. But, Plavix's effectiveness has not been proven in heart patients at greatest risk due to their history of gastrointestinal bleeding, and recent research indicates it actually may impair ulcer healing and markedly increase rates of bleeding.

"Clopidogrel inhibits new growth of small blood vessels in ulcers which is important for ulcer healing," said Dr. Cryer, a VA physician. "Although Plavix may not primarily cause gastrointestinal ulcers, through inhibition of new blood vessel growth, it may impair healing of background ulcers. When combined with the pr
'"/>

Contact: Scott Maier
scott.maier@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
19-Jan-2005


Page: 1 2

Related medicine news :

1. Low-dose transdermal estrogen viable short-term treatment for menopausal women
2. Low-dose interferon fails to improve survival in high-risk melanoma patients
3. Low-dose combo no better than aspirin alone in secondary prevention
4. Low-dose oral contraceptives are as protective against ovarian cancer as are older, high-dose pills, find University of Pittsburgh researchers
5. Many postmenopausal women with cardiovascular disease dont use lifesaving aspirin therapy
6. Survivors who stop taking aspirin increase risk of another stroke
7. Study says 43% of US adults at risk of heart disease are not utilizing aspirin therapy
8. Statins and aspirin may protect against severe vision loss in elderly
9. One in five asthmatics are highly sensitive to aspirin
10. Baby and coated aspirin equally effective in thinning of blood when taken in combination with Plavix
11. Study supports role of aspirin in reducing risk of colorectal cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/18/2018)... ... October 18, 2018 , ... Today Jon Elwell, CEO ... in healthcare, told attendees of the National Association of Long Term Hospitals ... series, you always began with the understanding that Waldo was in the picture somewhere. ...
(Date:10/17/2018)... ... ... Power to Decide, the campaign to prevent unplanned pregnancy, announced the launch ... support from the HHS Office of Adolescent Health, Innovation Next is a unique accelerator ... on technology-enabled ideas. , This year, five new teams will be selected to participate ...
(Date:10/16/2018)... ... October 16, 2018 , ... CCC ( ... midstream and downstream operators today announces Total Train Comprehensive Release version 14.1 (TTCR ... critical system components focused on improving cybersecurity defense around turbomachinery. The upgrade ...
(Date:10/16/2018)... ... October 16, 2018 , ... ... to provide simple, easy-to-use software for biopharma companies. By pairing the InTime time ... those crucial resourcing questions without spending millions of dollars implementing a complicated enterprise ...
(Date:10/16/2018)... ... October 15, 2018 , ... ... VALIDATE® Body Fluids, Order Number 205bf, for easier linearity and calibration verification. ... documentation of linearity, calibration verification and verification of the reportable range for Albumin ...
Breaking Medicine News(10 mins):
(Date:10/16/2018)... , ... October 16, 2018 , ... ... Applied Logic, the St. Louis based surgical tracking software company. Censis is the ... customers and employees to make a difference using their strong portfolio of solutions, ...
(Date:10/16/2018)... ... October 16, 2018 , ... AMGtime will be exhibiting at ... Center. At booth 1940, AMGtime will showcase time, labor management, and scheduling solutions ... their specialized Skilled Nursing Facility module . , Designed to appease common ...
(Date:10/13/2018)... (PRWEB) , ... October 13, 2018 , ... As news ... 14.4 per cent over the next five years, from $3200 million in 2017 to ... driver and could even help drive this growth further. This news comes hot on ...
Breaking Medicine Technology:
Cached News: