Low platelet counts linked to decreased survival in HIV-infected women

SAN DIEGO (Dec. 5, 2004) - HIV-positive women with low blood platelet counts face significantly higher risk of death compared to women with normal counts, according to a study presented today at the 46th Annual Meeting of the American Society of Hematology.

Findings come from the Women's Interagency HIV Study, or WIHS, a prospective study of women living with HIV (as well as HIV-negative women for comparison) in six urban areas across the United States. In this portion of the study, researchers looked at 1,990 HIV-infected women and 553 HIV-negative women.

When entering the study, 15 percent of HIV-positive women and less than 2 percent of the HIV-negative women had low blood platelet counts, also called thrombocytopenia. Platelets are minute cells in the blood that help in the blood clotting process.

The researchers found that women with thrombocytopenia-a platelet count of fewer than 50,000 platelets per cubic millimeter-had a five-fold increase risk of dying due to any cause, compared to women with normal platelet counts. Thrombocytopenia also was linked to a three-fold risk of dying due to AIDS.

"Only a low CD4+ lymphocyte count, one under 200 cells per cubic millimeter, could compare in the strength of its link to mortality," says WIHS principal investigator Alexandra M. Levine, M.D., Distinguished Professor of Medicine, chief of hematology at the Keck School of Medicine of USC and medical director of the USC/Norris Cancer Hospital. Physicians have long relied on counts of CD4+ lymphocyte as a key measure of immunosuppression in HIV-infected patients.

Fortunately, many women saw their platelet counts boosted back to normal through use of highly active antiretroviral therapy, or HAART, especially therapy containing zidovudine, also called AZT.

Researchers found that factors associated with increased risk of thrombocytopenia included HIV infection, low CD4+ lymphocyte counts, increasing viral load, and smoking. Int

Contact: Sarah Huoh
University of Southern California

Page: 1 2

Related medicine news :

1. Three anti-platelet drugs used in combination are safe
2. How platelets help cancer invade other tissues
3. Binge drinking: red wine and alcohol have different effects on platelets
4. Antiplatelet drug found to reduce risk of recurrent heart attacks and stroke is cost-effective
5. Antiplatelet drugs: comparison of clopidogrel with aspirin
6. Study shows combining antiplatelet drug Abciximab with clot-buster is effective in treating heart-attack patients
7. Laser method identifies, counts toxic molecules
8. For healthy diet, learning level counts more than earning level
9. USC researchers find ozone lowers sperm counts
10. Hand size counts in safe handgun use
11. Study finds factors linked to substance use disorder relapse among health care professionals

Post Your Comments:

(Date:10/12/2015)... ... October 12, 2015 , ... ... secured a new corporate headquarters, located at 485 Madison Avenue, New York, NY ... and increased emphasis on cloud-based technology. , “Care to Care is a dynamic ...
(Date:10/12/2015)... ... October 12, 2015 , ... In the first known ... individuals involved in nursing research spent as much as the equivalent of four 40-hour ... a single successful National Institutes of Health (NIH) grant application for funds to conduct ...
(Date:10/12/2015)... ... October 12, 2015 , ... CMS’s just-released 2016 Medicare ... partners to assess and act on, indicating which stars measures are causing plans the ... Part D health plans should focus their efforts and how CMS intends to modify ...
(Date:10/12/2015)... ... October 12, 2015 , ... T.E.N., a technology ... evening, October 8, at the 2015 ISE® Northeast Executive Forum and Awards ... , Michael Towers, VP, executive information security officer for Allergan, was selected as ...
(Date:10/12/2015)... ... October 12, 2015 , ... On Sunday, October 18, the Sierra Regional Spine ... in support of all Washoe County students. This is the first time the institute ... Sparks Marina outlet mall outside Reno, Nevada. , The family and youth-focused event features ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 12, 2015 The global infertility treatment ... million by 2020 from USD 1,822.32 million in ... and 2020. By product, the market includes antivibration ... systems, micromanipulator systems, ovum aspiration pumps, sperm analyzer ... market is segmented into in vitro fertilization, artificial ...
(Date:10/12/2015)... , Oct. 12, 2015  CME Group,s Center for ... and CEO of Theranos, is the 11 th recipient ... founded the revolutionary blood diagnostics company, Theranos , to ... usher in a new era of preventive care. CME Group ... Financial Leadership Conference in Naples, Florida ...
(Date:10/12/2015)... October 12, 2015 ... Pipeline Review, H2 2015 market research report provides ... pipelines by identifying new targets and MOAs to ... . --> http://www.rnrmarketresearch.com/plague-pipeline-review-h2-2015-market-report.html . ... spread across 62 pages, analyzing 6 companies, 8 ...
Breaking Medicine Technology:
Cached News: