HOME >> MEDICINE >> NEWS
Macrophages from human lymphoma patients cause mouse lymphoma in mice, UCSF study finds

UCSF researchers have found that macrophages--literally "big eaters," normally key immune defense cells that engulf and devour bacteria and tumor cells--when taken from HIV-infected lymphoma patients and injected into mice, induced aggressive mouse T-cell lymphomas in the mice. Macrophages from healthy donors did not.

"This research establishes that macrophages can cause disease as opposed to current dogma which asserts that the purpose of these cells is benevolent, solely to assist in fighting disease," said the study's lead investigator, Michael S. McGrath, MD, PhD, UCSF professor of laboratory medicine at UCSF's Positive Health Program at San Francisco General Hospital Medical Center (SFGHMC). The study is published in the October issue of Cancer Research.

Researchers used SCID (severe combined immunodeficiency disease) mice that lack functional T and B lymphocytes and are used for the study of human lymphoid tissues. They injected mice with tumor cells--some with macrophages and lymphoma cells together, some with macrophages separately, and some with lymphoma cells separately--from HIV-infected patients with a rare form of non-Hodgkin's lymphoma. They also injected some mice with normal human macrophages from healthy subjects.

"Most scientists believe that the macrophages present in tumors are there to help fight the cancer," said McGrath.

The mice injected with both macrophages and lymphoma cells from the HIV-infected lymphoma patients and mice injected with only the macrophages (separated from the lymphoma cells) from the HIV-infected lymphoma patients developed lymphomas.

None of the mice injected with just the lymphoma T-cells from the HIV-infected lymphoma patients and none of the mice injected with normal human macrophages from healthy subjects developed lymphomas.

"Our theory is that, during HIV infection, disease associated macrophages have HIV inserted near growth promoting genes allowing macrophages
'"/>

Contact: Jeff Sheehy
jsheehy@psg.ucsf.edu
415-597-8165
University of California - San Francisco
30-Sep-2002


Page: 1 2

Related medicine news :

1. UIC professor receives international humanitarian award
2. UCSF study offers insight into human circadian rhythms
3. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
4. Protecting human subjects focus of national FDA conference at UH
5. Test could improve detection of prion disease in humans
6. Murder, eyewitness identification and the limits of human vision
7. Nonhuman primate males more susceptible to age-related cognitive decline than females
8. Diffusion-weighted MRI can diagnose mad cow-related disease in humans before symptoms show
9. Mice with depression-like behaviors reveal possible source of human depression
10. The human eye cannot spot the offside rule
11. Researchers describe how human blood stem cells transform themselves to repair injured animal hearts

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2019)... ... June 19, 2019 , ... ... International Research Congress (IRC) in Marseille, France. The conference is widely seen ... on facioscapulohumeral muscular dystrophy (FSHD). Nearly 200 researchers, clinicians, industry representatives and patient ...
(Date:6/18/2019)... ... June 18, 2019 , ... Cosmetic Town, ... the world of cosmetic facial rejuvenation in June. The Cosmetic Town website will ... experienced in performing various methods of cosmetic facial rejuvenation and videos that take ...
(Date:6/16/2019)... Kan. (PRWEB) , ... June 15, 2019 , ... All ... traumatic experiences, poverty, untreated mental health needs and lack of a support network, they ... is made to remove the children from the home and place them with a ...
(Date:6/14/2019)... ... June 14, 2019 , ... This past Saturday, volunteers ... their dedicated support staff hosted the Parma Heights Day of Giving, where members of ... the event through local nonprofits that partnered with the Smiles for Everyone Foundation. ...
(Date:6/13/2019)... ... June 13, 2019 , ... In Partnership with the ... services for low-income, underinsured individuals at its Mesquite, TX office on July 13th. , ... cleanings and extractions . For more information, please visit the ...
Breaking Medicine News(10 mins):
(Date:6/19/2019)... ... , ... “We sometimes take out teeth for granted,” said Arroyo Grande dentist Dr. ... our teeth unless it’s baby’s first tooth, that first visit from the tooth fairy, or ... very important role in our overall health. Each tooth is as unique to each individual ...
(Date:6/18/2019)... ... June 18, 2019 , ... MY Education ... Olympic Blvd Suite 350 Los Angeles, CA, 90064, bringing holistic solutions to families ... MY Education Guru has created individual programs to assist students who have difficulties ...
(Date:6/16/2019)... ... June 14, 2019 , ... AVIE! MedSpa and Laser Center is proud to ... and radiofrequency treatment for achieving dramatic improvements to the texture and tightness of skin ... stimulates the skin with tiny needles, spurring vibrant new collagen growth for a wide ...
Breaking Medicine Technology:
Cached News: