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Marijuana-derived drug less effective than standard drug for improving appetite and weight in patients with advanced cancer

re a standard drug to a drug derived from marijuana in an effort to help cancer patients with this problem, she said.

The study evaluated 469 cancer patients between December 1996 and December 1999. These patients were 18 years of age and older, and all had been diagnosed with an advanced cancer. They also had to have a self-reported loss of appetite and/or weight loss of at least five pounds during the preceding two months.

The double-blinded study randomly enrolled the patients into one of three treatment sections:
* megestrol acetate liquid given 800 mg orally each day plus capsule placebo
* dronabinol capsules given 2.5 mg orally twice a day plus liquid placebo
* a combination of both medications in the dosages noted

Dr. Jatoi noted that megestrol acetate is not the complete answer to stimulating appetite and boosting weight in cancer patients and more research needs to be done to find better drugs.

But at this time, we can say that megestrol acetate is more effective than dronabinol in the doses we tested, she said.


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Contact: Mary Lawson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
25-Jan-2002


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