Marijuana ingredient may stall decline from A...( protein with or without cannabinoids ...)

Marijuana ingredient may stall decline from Alzheimer's

protein with or without cannabinoids and those treated with the amyloid protein and cannabinoid were able to find the platform. Rats treated with amyloid protein alone did not learn how to find the platform.

The researchers found that the presence of amyloid protein in the rats' brains activated immune cells. Rats that received the control protein alone or cannabinoid and a control protein did not show activation of microglia. Using cell cultures, the investigators confirmed that cannabinoids counteracted the activation of microglia and thus reduced inflammation.

"These findings that cannabinoids work both to prevent inflammation and to protect the brain may set the stage for their use as a therapeutic approach for [Alzheimer's disease]," de Ceballos says. The scientists will now focus their efforts on targeting one of the two main cannabinoid receptors that is not involved in producing the psychotropic effects, or high, from marijuana.

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Contact: Elissa Petruzzi
elissa@sfn.org
202-462-6688
Society for Neuroscience
22-Feb-2005

Page: 1 2
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Marijuana ingredient may stall decline from A...( protein with or without cannabinoids ...),Health