HOME >> MEDICINE >> NEWS
Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

ks activity in the cannabinoid system can significantly reduce food intake in animals by triggering activity in another system that is known to regulate appetite and body weight," says study author Michael Cowley, PhD, of Oregon Health and Science University.

Obesity has risen at an epidemic rate during the past 20 years, according to the Centers for Disease Control and Prevention. More than 60 percent of adult Americans are overweight or obese. These people face an increased risk for a range of physical ailments, including high blood pressure, diabetes, and stroke.

"For many years anecdotal reports have described how marijuana use can increase appetite," says Cowley. "Some users describe these cravings as the munchies."

This and other work has prompted the development of drugs that combat appetite by blocking the cannabinoid receptors, which are activated by marijuana. "Some of these drugs are in late stage clinical trials," says Cowley. "How they are able to control eating, however, has been a mystery."

To shed some light on how they might work, Cowley and his colleagues gave mice a cannabinoid receptor blocker, termed AM251. "We found that the treated animals significantly reduced their food intake, as has been known for many years," says Cowley. "We also found evidence that the activity of brain cells involved in the melanocortin system, which is known to control food intake and energy balance, increased."

Several molecular measures signaled that there was increased activity in melanocortin brain cells. Included was the discovery that in treated animals there was a fourfold increase in the number of melanocortin brain cells that contained c-fos, a marker of cellular activation.

"These data show that cannabinoid receptor blockers can regulate the melanocortin pathways in animals and support the further development of cannabinoid blockers to help combat obesity in humans," says Cowley.


'"/>

Contact: Leah Ariniello
dawn@sfn.org
202-462-6688
Society for Neuroscience
26-Oct-2004


Page: 1 2 3 4 5

Related medicine news :

1. New compounds effective against Alzheimers disease onset and progression
2. New compounds show promise in fighting malaria and cancer
3. New class of compounds promises to revive failing hearts
4. Study finds certain compounds in beer, wine effective in slowing breast cancer cell growth
5. Researchers testing compounds that may stop replication of T-cell leukemia virus
6. Cocoa froths with cancer-preventing compounds
7. OneWorld Health licenses compounds from Yale, U of Washington to treat major parasitic diseases
8. Purdue stealth compounds attack cancer cells
9. Englewood researcher receives national award: Fights cancer with vaccines and compounds found in nature
10. Flu vaccination benefits people of any age with high-risk medical conditions
11. Most alcohol-related plane crashes occur at night and in worsening weather conditions

Post Your Comments:
(Date:4/20/2015)... (PRWEB) April 20, 2015 Early registration ... hurry and secure your space at the start line. ... the Olympic-distance race is limited to 500 participants (actually there’s ... already secured his spot). , Now thru April 30, the ... relay team members; after May 1st, the fee goes up ...
(Date:4/20/2015)... (PRWEB) April 20, 2015 Genuine fat loss ... diets and gym memberships in the past. But what failed ... results can be guaranteed by adhering to five simple ... diet. No matter how many hours one spends working at ... to lose weight., But a nutritional mean plan does not ...
(Date:4/20/2015)... 20, 2015 “ Verus ” was ... Report, which features the latest and coolest technology products ... special reporter for NewsWatch, conducted the review and shared ... variety of purposes. , According to CNET, at least ... in 2013. It’s unfortunate that smartphones break so easily, ...
(Date:4/20/2015)... Clara, CA (PRWEB) April 20, 2015 ... CA and were united as one until 1995. The group ... elements including blues, reggae, rock, bluegrass, folk, space rock, country, ... become known as the ultimate jam band. The group was ... 1994 and in total has sold more than 35 million ...
(Date:4/20/2015)... Tympani Inc., an IT consulting and ... services business 175% this year. Tympani offers a ... to its traditional IT infrastructure, communications and managed ... cloud partners Faction and Seagate Technology, will present ... a Cloud Symposium on April 23 in Rosemont, ...
Breaking Medicine News(10 mins):Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 3Health News:Guarantee Fat Loss Results With 5 Easy Tips 2Health News:Guarantee Fat Loss Results With 5 Easy Tips 3Health News:Attractive and Durable Phone Cases were Featured on NewsWatch Television 2Health News:Grateful Dead Tickets at Levi’s Stadium in Santa Clara: Ticket Down Slashes Grateful Dead Tickets in Santa Clara @ Levi’s Stadium for "Fare Thee Well" 50th Anniversary 2Health News:Tympani Grows Cloud Services Business 175%, Presents Cloud Symposium on April 23 2Health News:Tympani Grows Cloud Services Business 175%, Presents Cloud Symposium on April 23 3
(Date:4/20/2015)... 2015   Spirox Inc., a privately held ... an $18.5 million Series B round of financing led by ... Partners, Correlation Ventures and Western Technology Investment also ... a novel, minimally invasive system to be used ... plastic surgeons to treat patients with nasal obstruction, ...
(Date:4/20/2015)... , Apr. 14, 2015 Research and Markets ... the "US Proton Therapy Outlook - Market Opportunities" ... the US Proton Therapy Outlook: Market Opportunities by the ... be home to almost 29 such centers by 2018, ... Consequently, the market will breach the Billion dollar mark ...
(Date:4/20/2015)... , April 20, 2015   Gateway Rehab ... and Training Institute today expanded its Naloxone: Increasing ... locations.  A $50,000 grant from the Staunton ... project possible.  The yearlong research ... patients and their family members upon completion of ...
Breaking Medicine Technology:Spirox, Inc. Announces Closing of $18.5MM Series B Financing 2Spirox, Inc. Announces Closing of $18.5MM Series B Financing 3United States Proton Therapy Outlook to 2018 - Market Opportunities for the $1.19 Billion Market Featuring IBA, Hitachi, Mevion Medical Systems & Varian 2United States Proton Therapy Outlook to 2018 - Market Opportunities for the $1.19 Billion Market Featuring IBA, Hitachi, Mevion Medical Systems & Varian 3Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 2Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 3
Cached News: