HOME >> MEDICINE >> NEWS
Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

ks activity in the cannabinoid system can significantly reduce food intake in animals by triggering activity in another system that is known to regulate appetite and body weight," says study author Michael Cowley, PhD, of Oregon Health and Science University.

Obesity has risen at an epidemic rate during the past 20 years, according to the Centers for Disease Control and Prevention. More than 60 percent of adult Americans are overweight or obese. These people face an increased risk for a range of physical ailments, including high blood pressure, diabetes, and stroke.

"For many years anecdotal reports have described how marijuana use can increase appetite," says Cowley. "Some users describe these cravings as the munchies."

This and other work has prompted the development of drugs that combat appetite by blocking the cannabinoid receptors, which are activated by marijuana. "Some of these drugs are in late stage clinical trials," says Cowley. "How they are able to control eating, however, has been a mystery."

To shed some light on how they might work, Cowley and his colleagues gave mice a cannabinoid receptor blocker, termed AM251. "We found that the treated animals significantly reduced their food intake, as has been known for many years," says Cowley. "We also found evidence that the activity of brain cells involved in the melanocortin system, which is known to control food intake and energy balance, increased."

Several molecular measures signaled that there was increased activity in melanocortin brain cells. Included was the discovery that in treated animals there was a fourfold increase in the number of melanocortin brain cells that contained c-fos, a marker of cellular activation.

"These data show that cannabinoid receptor blockers can regulate the melanocortin pathways in animals and support the further development of cannabinoid blockers to help combat obesity in humans," says Cowley.


'"/>

Contact: Leah Ariniello
dawn@sfn.org
202-462-6688
Society for Neuroscience
26-Oct-2004


Page: 1 2 3 4 5

Related medicine news :

1. New compounds effective against Alzheimers disease onset and progression
2. New compounds show promise in fighting malaria and cancer
3. New class of compounds promises to revive failing hearts
4. Study finds certain compounds in beer, wine effective in slowing breast cancer cell growth
5. Researchers testing compounds that may stop replication of T-cell leukemia virus
6. Cocoa froths with cancer-preventing compounds
7. OneWorld Health licenses compounds from Yale, U of Washington to treat major parasitic diseases
8. Purdue stealth compounds attack cancer cells
9. Englewood researcher receives national award: Fights cancer with vaccines and compounds found in nature
10. Flu vaccination benefits people of any age with high-risk medical conditions
11. Most alcohol-related plane crashes occur at night and in worsening weather conditions

Post Your Comments:
(Date:8/27/2015)... ... 2015 , ... In mid-May, Logistics Trust, Inc. (“Logistics Trust”) ... of its Doobster platform, a HIPAA-compliant mobile application that allows medical marijuana patients ... and tablets. Well, Doobster, “The App That Delivers!” is here! You ...
(Date:8/27/2015)... ... ... The Naderi Center is proud to announce that its own Dr. Jessica ... fat. The first and only Food and Drug Administration (FDA) approved treatment for ... only Board Certified surgeon in the D.C., Maryland, Virginia area to offer this innovative, ...
(Date:8/27/2015)... ... August 27, 2015 , ... Zensah®, ... Glushko, professional Tennis player for Israel in the Women’s Tennis Association (WTA). Glushko ... her training and recovery. , With a focus on technology and comfort, Zensah® ...
(Date:8/27/2015)... OKLAHOMA CITY, OK (PRWEB) , ... August 27, ... ... Partners (“GPP”) I, LP portfolio company and leading biopharmaceutical contract development manufacturing company ... acquired by Hepalink USA Inc. (“Hepalink”) for $205.68M in cash. , ...
(Date:8/27/2015)... , ... August 27, 2015 , ... Susan Harris ... procedure to relieve vaginal discomfort due to pre- and post-menopause, chemotherapy, and child birth. ... CO2 laser, which delivers controlled energy to the vaginal tissue, revitalizing cells so they ...
Breaking Medicine News(10 mins):Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 2Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 3Health News:Great Point Partners, LLC Announces that Hepalink USA Inc. Agrees to Acquire Cytovance Biologics, Inc. 2Health News:Great Point Partners, LLC Announces that Hepalink USA Inc. Agrees to Acquire Cytovance Biologics, Inc. 3Health News:Great Point Partners, LLC Announces that Hepalink USA Inc. Agrees to Acquire Cytovance Biologics, Inc. 4Health News:LifeStream Health Centre & MedSpa Announces New Treatment for Vaginal Discomfort 2Health News:LifeStream Health Centre & MedSpa Announces New Treatment for Vaginal Discomfort 3
(Date:8/27/2015)... , Aug. 27, 2015 Major pharmaceutical and ... at a legal conference in Philadelphia ... emerging issues, Tom Hagy of HB Litigation Conferences ... event, visit HB,s website at http://litigationconferences.com/?p=31886 ... Segal McCambridge Singer & Mahoney and Michelle Hart Yeary ...
(Date:8/27/2015)... 27, 2015 Itamar Medical Ltd. ... investment in public equity (PIPE) deal, in which Viola ... Itamar Medical.   Through this deal, Viola ... Medical and will work closely with the company,s management ... to the investment agreement, Itamar Medical will issue shares ...
(Date:8/27/2015)... , August 27, 2015 ... Persistence Market Research titled "Global Market Study on ... Growth by 2021", the urinary catheters market is expected to ... of 2015. It is anticipated to expand at ... reach US$1,755.0 Mn by 2021. View ...
Breaking Medicine Technology:Pharmaceutical, Medical Device Law Seminar Features In-House, Outside Counsel 2Pharmaceutical, Medical Device Law Seminar Features In-House, Outside Counsel 3Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 2Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 3Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 4Viola Private Equity Invests up to $28.4 Million in Itamar Medical and Becomes the Largest Shareholder of the Company 5Global Urinary Catheters Market Will Reach US$1,755.0 Mn by 2021: Persistence Market Research 2Global Urinary Catheters Market Will Reach US$1,755.0 Mn by 2021: Persistence Market Research 3Global Urinary Catheters Market Will Reach US$1,755.0 Mn by 2021: Persistence Market Research 4
Cached News: