HOME >> MEDICINE >> NEWS
Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

ks activity in the cannabinoid system can significantly reduce food intake in animals by triggering activity in another system that is known to regulate appetite and body weight," says study author Michael Cowley, PhD, of Oregon Health and Science University.

Obesity has risen at an epidemic rate during the past 20 years, according to the Centers for Disease Control and Prevention. More than 60 percent of adult Americans are overweight or obese. These people face an increased risk for a range of physical ailments, including high blood pressure, diabetes, and stroke.

"For many years anecdotal reports have described how marijuana use can increase appetite," says Cowley. "Some users describe these cravings as the munchies."

This and other work has prompted the development of drugs that combat appetite by blocking the cannabinoid receptors, which are activated by marijuana. "Some of these drugs are in late stage clinical trials," says Cowley. "How they are able to control eating, however, has been a mystery."

To shed some light on how they might work, Cowley and his colleagues gave mice a cannabinoid receptor blocker, termed AM251. "We found that the treated animals significantly reduced their food intake, as has been known for many years," says Cowley. "We also found evidence that the activity of brain cells involved in the melanocortin system, which is known to control food intake and energy balance, increased."

Several molecular measures signaled that there was increased activity in melanocortin brain cells. Included was the discovery that in treated animals there was a fourfold increase in the number of melanocortin brain cells that contained c-fos, a marker of cellular activation.

"These data show that cannabinoid receptor blockers can regulate the melanocortin pathways in animals and support the further development of cannabinoid blockers to help combat obesity in humans," says Cowley.


'"/>

Contact: Leah Ariniello
dawn@sfn.org
202-462-6688
Society for Neuroscience
26-Oct-2004


Page: 1 2 3 4 5

Related medicine news :

1. New compounds effective against Alzheimers disease onset and progression
2. New compounds show promise in fighting malaria and cancer
3. New class of compounds promises to revive failing hearts
4. Study finds certain compounds in beer, wine effective in slowing breast cancer cell growth
5. Researchers testing compounds that may stop replication of T-cell leukemia virus
6. Cocoa froths with cancer-preventing compounds
7. OneWorld Health licenses compounds from Yale, U of Washington to treat major parasitic diseases
8. Purdue stealth compounds attack cancer cells
9. Englewood researcher receives national award: Fights cancer with vaccines and compounds found in nature
10. Flu vaccination benefits people of any age with high-risk medical conditions
11. Most alcohol-related plane crashes occur at night and in worsening weather conditions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/29/2016)... Cary, North Carolina (PRWEB) , ... May 29, 2016 , ... ... KP-400L wide jaw clipper that has been available via Amazon.com. This new ... who have thick nails. , The jaw opening is approximately 4mm and the actual ...
(Date:5/29/2016)... ... May 29, 2016 , ... "With 30 unique self-animating ... user control the style of their project," said Christina Austin - CEO of Pixel ... web-themed intros created exclusively for use in Final Cut Pro X. Pixel Film Studios’ ...
(Date:5/28/2016)... ... 2016 , ... "Color Grading media can be time consuming but with FCPX ... said Christina Austin - CEO of Pixel Film Studios. , With the FCPX ... color grades to their footage. A LUT is a Lookup Table that contains a ...
(Date:5/28/2016)... ... ... and a half of planning the Multiple Pathways of Recovery Conference , CCAR is ... was held May 2 -4, 2016 at the Mystic Marriott Hotel & Spa . ... many pathways individuals use to get into and sustain their recovery. Pathways of recovery ...
(Date:5/27/2016)... Angeles, CA (PRWEB) , ... May 27, 2016 , ... ... of Health, so it is not surprising that bariatric surgery has received increased attention ... Business Journal explains. Of course, when it comes to weight loss, most people are ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... India , May 30, 2016 /PRNewswire/ ... market research report "Healthcare Biometrics Market by ... (Signature, Voice)), Multifactor, Multimodal), Application (Workforce Management), ... Forecast to 2021", published by MarketsandMarkets, the ... Million by 2021 from USD 1,182.6 Million ...
(Date:5/30/2016)... 2016 The global  parenteral ... billion by 2024, according to a new report ... rate, the growing malnutrition coupled with the prevalence ... tract diseases are expected to boost the market ... http://photos.prnewswire.com/prnh/20150105/723757 ) , The ...
(Date:5/30/2016)... 30, 2016 - DCGI grants limited approval ... Buerger,s disease - Stempeucel® becomes 5th off-the-shelf Stem cell ... world - Buerger,s Disease (also known as Thromboangiitis Obliterans) ... and Globally - Prevalence of Buerger,s Disease is ... 2 per 10,000 persons in the European Community & ...
Breaking Medicine Technology:
Cached News: