HOME >> MEDICINE >> NEWS
Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain

ks activity in the cannabinoid system can significantly reduce food intake in animals by triggering activity in another system that is known to regulate appetite and body weight," says study author Michael Cowley, PhD, of Oregon Health and Science University.

Obesity has risen at an epidemic rate during the past 20 years, according to the Centers for Disease Control and Prevention. More than 60 percent of adult Americans are overweight or obese. These people face an increased risk for a range of physical ailments, including high blood pressure, diabetes, and stroke.

"For many years anecdotal reports have described how marijuana use can increase appetite," says Cowley. "Some users describe these cravings as the munchies."

This and other work has prompted the development of drugs that combat appetite by blocking the cannabinoid receptors, which are activated by marijuana. "Some of these drugs are in late stage clinical trials," says Cowley. "How they are able to control eating, however, has been a mystery."

To shed some light on how they might work, Cowley and his colleagues gave mice a cannabinoid receptor blocker, termed AM251. "We found that the treated animals significantly reduced their food intake, as has been known for many years," says Cowley. "We also found evidence that the activity of brain cells involved in the melanocortin system, which is known to control food intake and energy balance, increased."

Several molecular measures signaled that there was increased activity in melanocortin brain cells. Included was the discovery that in treated animals there was a fourfold increase in the number of melanocortin brain cells that contained c-fos, a marker of cellular activation.

"These data show that cannabinoid receptor blockers can regulate the melanocortin pathways in animals and support the further development of cannabinoid blockers to help combat obesity in humans," says Cowley.


'"/>

Contact: Leah Ariniello
dawn@sfn.org
202-462-6688
Society for Neuroscience
26-Oct-2004


Page: 1 2 3 4 5

Related medicine news :

1. New compounds effective against Alzheimers disease onset and progression
2. New compounds show promise in fighting malaria and cancer
3. New class of compounds promises to revive failing hearts
4. Study finds certain compounds in beer, wine effective in slowing breast cancer cell growth
5. Researchers testing compounds that may stop replication of T-cell leukemia virus
6. Cocoa froths with cancer-preventing compounds
7. OneWorld Health licenses compounds from Yale, U of Washington to treat major parasitic diseases
8. Purdue stealth compounds attack cancer cells
9. Englewood researcher receives national award: Fights cancer with vaccines and compounds found in nature
10. Flu vaccination benefits people of any age with high-risk medical conditions
11. Most alcohol-related plane crashes occur at night and in worsening weather conditions

Post Your Comments:
(Date:10/31/2014)... 2014 Energy Textiles has recently added ... gear is now available online, and Energy Textile is ... Celliant infrared-active athletic gear over compression gear. , ... has been signed for Under Armour to provide team ... eight years. In light of this decision, Energy Textiles ...
(Date:10/31/2014)... In terms of duration of treatment and cost, ... from accelerated partial breast irradiation (APBI) with proton ... new research from The University of Texas MD ... a cost analysis study based on typical patient ... allowable charges for eight different types of partial ...
(Date:10/31/2014)... Gold Medal Wine Club is making it ... for the wine novice and enthusiasts on their lists with ... , which Early Bird shoppers receive discounts as high as ... , Gift Givers must place their orders before November ... Gold Medal Wine Club adds more value to its Wine ...
(Date:10/31/2014)... a drug combination that can trigger the self-destruct process ... new treatments, according to research that will be presented ... in Liverpool next week*. , When healthy cells are ... culminating in self destruction. But cancer cells swerve away ... that cells grow out of control – causing tumours ...
(Date:10/31/2014)... 2014 Triple Board Certified surgeon ... services to transform the appearance of military veteran Joseph ... of Facial Plastic and Reconstruction Surgery (AAFPRS) Faces of ... the facial hair Jones lost during an IED blast ... hair restoration procedure, valued around $16,000, took Dr. Epstein ...
Breaking Medicine News(10 mins):Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 2Health News:Proton therapy shown to be less costly than some alternative radiotherapy techniques 3Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2Health News:Scientists trigger self-destruct switch in lung cancer cells 2Health News:Miami Hair Restoration Specialist Transforms Wounded Soldier 2
(Date:10/31/2014)... , Oct. 31, 2014  Digirad Corporation (Nasdaq: DRAD) today ... Inc. (Nasdaq: PDII ), a healthcare commercialization ... proposal to acquire the company.  Digirad ... regarding a transaction and to operate in the ordinary ... or take on additional debt, on acquisitions or other ...
(Date:10/31/2014)... -- Grammy Award-winner Bruce Hornsby will give an ... actors, and musicians during the 10 th Annual ... Mandarin Oriental Hotel in New York City ... individuals who embody the values of the Orthopaedic Foundation. ... honor, the Spirit of an Active Lifestyle Award, to ...
(Date:10/31/2014)... Oct. 31, 2014  Australian biopharmaceutical company Specialised Therapeutics ... (nanoparticle albumin-bound paclitaxel) in combination with gemcitabine, will be ... with metastatic pancreatic cancer from 1 November. ... is the 5 th most common cause of ... cancer deaths, with the lowest 5-year survival of all ...
Breaking Medicine Technology:Digirad Delivers Letter To PDI, Inc. Responding To PDI's Summary Rejection Of Digirad's Offer To Acquire Company 2Digirad Delivers Letter To PDI, Inc. Responding To PDI's Summary Rejection Of Digirad's Offer To Acquire Company 3Digirad Delivers Letter To PDI, Inc. Responding To PDI's Summary Rejection Of Digirad's Offer To Acquire Company 4Digirad Delivers Letter To PDI, Inc. Responding To PDI's Summary Rejection Of Digirad's Offer To Acquire Company 510th Anniversary Orthopaedic Foundation Gala Set For Success 2Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 2Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 3Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 4Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 5Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 6Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 7Specialised Therapeutics Australia Announces Breakthrough Cancer Drug Abraxane(R) to be PBS Listed for Metastatic Pancreatic Cancer 8
Cached News: