Mast cells to blame for allergic diarrhea

While exposure to food allergens is often associated with diarrhea in humans, knowledge of the cell types and mediators involved in the process is still limited.

A report from Marc Rothenberg and colleagues from Cincinnati Children's Hospital Medical Center, Ohio, in the December 4 issue of the Journal of Clinical Investigation describes the use of a murine model of oral allergeninduced intestinal inflammation accompanied by strong Th2-associated humoral and cellular responses.

Mice had dose-dependent acute diarrhea associated with increased intestinal permeability, and an increase in granular white blood cells (eosinophilia) and mast cells (mastocytosis). Depletion of mast cells completely abrogated intestinal mastocytosis and blocked the allergic diarrhea.

Furthermore, allergic diarrhea was dependent upon synergistic signaling induced by serotonin and platelet-activating factor (PAF), but not histamine. Additional experiments indicated that the numerous eosinophils present in the intestines did not contribute to the diarrhea.

These results demonstrate that oral allergeninduced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, serotonin, and PAF dependent. The identified mechanism also suggests that agents such as anti-IgE, recently approved for the treatment of human asthma, and the c-kit inhibitor imatinib mesilate, recently approved for the treatment of various malignancies, may also have therapeutic utility for gastrointestinal allergy.


Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1

Related medicine news :

1. Suppressing the cells that trigger cat allergy
2. Indiana University researchers closer to helping hearing-impaired using stem cells
3. Some brain cells change channels to fine-tune the message
4. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
5. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
6. Study suggests smoking while pregnant may increase chromosomal abnormalities in fetal cells
7. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
8. Smart immune cells kill more cancer
9. CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
10. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
11. PCBs, fungicide open brain cells to Parkinsons assault

Post Your Comments:

(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: