VANCOUVER, BC (May 7, 2004)Researchers today announced new clinical evidence showing that long-term use of maximum recommended over-the-counter (OTC) daily doses of acetaminophen (APAP) provide efficacy comparable to prescription doses of naproxen (NAP) for the management of mild-to-moderate osteoarthritis (OA) pain of the hip or knee.
Preliminary analyses of the multicenter, randomized, double-blind, parallel-group, comparative study involving 551 patients aged 40 to 75 years old with mild-to-moderate OA of the hip or knee were presented during the 2nd Joint Scientific Meeting of the American Pain Society and the Canadian Pain Society. Patients in the APAP-treated group (n=276) received 4000mg per day, while those in the NAP group (n=275) received 750 mg per day. All patients were evaluated at one-, three-, and six-month intervals for pain, stiffness, and physical function using the WOMAC* subscale for pain.
Even out to six months, our analyses showed no statistical differences between the efficacy of acetaminophen and naproxen for the management of osteoarthritis pain of the hip and knee, said Dr. Anthony Temple, VP Medical Affairs, McNeil Consumer & Specialty Pharmaceuticals. These results indicate that acetaminophen is as effective as prescription doses of naproxen for the pain of arthritis when administered for up to 6 months under the care and observation of the physician.
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Contact: Ami Schmitz-Levine
D. J. Storch & Associates Inc.
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