HOME >> MEDICINE >> NEWS
Mayo Clinic discovers important clue to new treatments for lymphoma, breast and colon cancers

ROCHESTER, Minn. -- Mayo Clinic cancer researchers have discovered a key partnership between two genes in mice that prevents the development of cancer of the lymph nodes, known as T-cell leukemia or lymphoma.

This first-time finding provides researchers with a promising target for designing new anti-cancer drugs that fight lymphomas, as well as other cancers in which this partnership exists, including breast and colon cancers.

The Mayo Clinic research report appears as the cover story in today's edition of the journal, Cancer Cell, (http://www.cancercell.org). Jan van Deursen, Ph.D., a specialist in pediatric cancers with the Department of Pediatrics and a member of the Mayo Clinic Cancer Center, led the research team.

According to Dr. van Deursen, the Mayo Clinic cancer research team used specially-bred laboratory mice to demonstrate three things not previously known about the development of these types of cancer. They are the first to:

  • Provide laboratory evidence that the gene CBP is a tumor suppressor -- and that the lack of CBP contributes to the formation of lymphoma.
  • Demonstrate that the absence of CBP works in partnership with low levels of a protein called p27Kip1. When these two conditions are present, lymphoma development accelerates in mice.
  • Discover that two compounds -- Cyclin E and Skp2 -- control p27Kip1 levels.
"We not only found the tumor suppressor, we also showed what other gene defects need to occur in the same cell for cancer to progress," says Dr. van Deursen. "Cancer is not the result of a single defect, but is related to a combination of defects and events," he explains. "To find the best treatment, it's vital to discover what combinations of changes have occurred with the cell to transform it from a normal cell into a cancer cell."

Lymphoma belongs to the hematologic malignancies group of cancer
'"/>

Contact: Mary Lawson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
23-Feb-2004


Page: 1 2

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
(Date:4/26/2015)... York (PRWEB) April 26, 2015 This ... events of the season and will include a spectacular ... purses, totes, collectibles, herbal soaps and incense, chimes, vases, ... browsing this year’s exciting and unique collection of vendors, ... afternoon with Jim Martocci and the Jimmie Jazz Band. ...
(Date:4/25/2015)... DC (PRWEB) April 26, 2015 The ... Seniors (ACE.S) , a national endeavor to prepare nurses ... adults, is a great success, according to a new ... the program's original funding partners. , The project ... of Philadelphia (CCP), under the direction of Elaine Tagliareni, ...
(Date:4/25/2015)... 25, 2015 In the United States ... above needed treatment for an illicit drug ... Abuse and Mental Health Services Administration’s Survey on Drug ... alarming numbers are harrowing stories of men and women ... . David H. Kerr , founder and retired ...
(Date:4/25/2015)... Turks and Caicos Islands, BWI (PRWEB) April 25, 2015 ... International Airport (PLS) has celebrated three months of successfully ... reopening on January 5, 2015. , As part ... the interior of Providenciales airport was completely redesigned to ... has quickened up the process of getting out of ...
(Date:4/25/2015)... Dallas, TX/Minneapolis, MN (PRWEB) April 25, 2015 ... as the recipient of RFID Journal’s annual Best Implementation ... company that has demonstrated the best use of RFID ... operations. The winner is the company that best demonstrates ... The award was presented at RFID Journal Live! 2015 ...
Breaking Medicine News(10 mins):Health News:It’s Coming! The 5th Annual Tulip Festival & Mother’s Day Celebration at Honor's Haven Resort & Spa! 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 3Health News:New Book Features Powerful Stories of People Who Overcame Addiction 2Health News:New Book Features Powerful Stories of People Who Overcame Addiction 3Health News:The Tuscany on Grace Bay Celebrates Providenciales Airport Expansion With Summer Specials to Travelers! 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2
(Date:4/24/2015)...  Novartis Pharmaceuticals Corporation (NPC) has been named the top ... on the annual DiversityInc Top 50 Companies for Diversity listing. ... for Diversity on April 23 at an awards ceremony in ... second on the DiversityInc Top 10 Companies for Recruitment list ... Groups list. David Epstein , Division ...
(Date:4/24/2015)... , April 24, 2015  Lannett Company, Inc. (NYSE: ... and increased its five-year revolving credit facility to $120 ... accordion feature that will allow the company to increase ... $30.0 million, subject to securing additional commitments from existing ... the credit facility remains December 18, 2018.   ...
(Date:4/24/2015)... Spain , April 24, 2015  Elekta has ... Monaco® treatment planning system , enabling European clinics ... supports major treatment techniques including advanced 3D planning, IMRT, ... system. Monaco ... as well improved workflow efficiency. Advancements in 3D planning ...
Breaking Medicine Technology:Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4Lannett Expands Revolving Credit Facility To $120 Million 2Elekta CE marks for Monaco v5.10 treatment planning system 2
Cached News: