HOME >> MEDICINE >> NEWS
Mayo Clinic discovers 'new pathway' against pancreatic cancer

ROCHESTER, Minn. -- Pancreatic cancer kills 30,000 Americans every year. Not only is there no cure, but there are no effective treatments. That may change if a new finding by Mayo Clinic researchers continues to show promise. In the March 15 issue of the journal Cancer Research, (http://cancerres.aacrjournals.org/future/65.6.shtml) investigators describe discovering a key molecule that controls the growth, spread and survival of pancreatic cancer cells. This is a critical first step toward developing new and better treatments for patients with pancreatic cancer.

"This is a very exciting -- and surprising -- finding," says Daniel Billadeau, Ph.D., lead author of the report. To identify new target molecules with potentially therapeutic impact for a cancer for which there is currently no real useful treatment is incredibly important.

"Based on the literature, you would predict the opposite of what we found. But in fact, we determined that we can decrease a known regulator of cancer cell survival -- in effect, turn this regulator off -- and when we do, the pancreatic cancer cells undergo apoptosis (commit cell suicide) and die."

Significance of the Research

  • With this finding, a new path is cleared for researchers to target these key molecular players with new small molecule inhibitors to block their action, effectively turning off molecules that promote pancreatic cancer growth.

  • The finding may be applied to make pancreatic cells more sensitive to gemcitabine, the sole drug available for treating pancreatic cancer.

  • This discovery may lead to new drug development strategies for other cancers. Additional research will tell whether these same actors play a similar role in the spread of other cancer types.

    The Key Finding

    The Mayo Clinic researchers discovered a previously unrecognized role in pancreatic cancer for
    '"/>



  • Contact: Bob Nellis
    newsbureau@mayo.edu
    507-284-5005
    Mayo Clinic
    15-Mar-2005


    Page: 1 2

    Related medicine news :

    1. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
    2. Mayo Clinic study sets threshold for valve repair surgery
    3. Mayo Clinic researcher calls for improved newborn screening
    4. Mayo Clinic study finds obese kidney donors face few increased risks
    5. Mayo Clinic identifies key cellular process in prostate and other cancers
    6. Clinical breast examination offers modest benefit to breast cancer screening program
    7. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
    8. Clinicians report missing patient information is common
    9. Mayo Clinic discovers a key to low metabolism and major factor in obesity
    10. Clinical trial of Etanercept for Wegeners disease shows no benefit
    11. Mayo Clinic researchers identify new form of muscular dystrophy in adults

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:5/14/2019)... ... May 14, 2019 , ... ... services to the healthcare industry, announced today that John Stanley, Vice President, has ... Stanley, Impact’s Market Leader for the Western U.S., has been recognized in the ...
    (Date:5/14/2019)... ... May 14, 2019 , ... A high number of HIV ... top health crises in the Houston area and the southern United States. Specifically, the ... who have sex with men (MSM) and transgender people of color ages ...
    (Date:5/14/2019)... ... May 14, 2019 , ... Relatient, Inc., a ... eRegistration and Check-In solution , a new product launched to reduce patient wait ... on Relatient’s Patient Engagement platform introducing earlier touch points on the ...
    (Date:5/14/2019)... ... May 14, 2019 , ... Forty-two billion dollars ... and procedures, according to market analysis company Orbis Research. “Treatments certainly can help,” ... Advanced Dermatology PC , “but for our skin, there’s free super-potent anti-aging care ...
    (Date:5/14/2019)... ... ... Dr. Steven Shoshany has been treating patients experiencing both acute and long term ... device, becoming the first chiropractor in Manhattan to do so. Since January, Dr. Shoshany ... treating pain and injuries, into his downtown practice. He recently finished designing a new ...
    Breaking Medicine News(10 mins):
    (Date:5/16/2019)... ... May 16, 2019 , ... Though Nefertiti’s Secret—a book by nationally renowned ... Amazon since April 2019, the author is officially celebrating its publication with a launch ... from 5 to 6:30 p.m., then opens to the public at 7 p.m. , ...
    (Date:5/15/2019)... , ... May 15, 2019 , ... Concerto Renal ... in skilled nursing facilities (SNFs), is acquiring Home Dialysis of Maryland (HDOM). ... expand Concerto’s annual dialysis population to over 2,200 patients in 40 SNFs. The acquisition ...
    (Date:5/15/2019)... ... , ... NDA Partners Chairman Carl Peck, MD , announced today that ... and expert in pediatric and neonatal clinical trials and therapies, has joined the firm ... Pediatrics for Experimental Therapeutics, the Evan and Cindy Jones Chair in Pediatric Clinical Pharmacology, ...
    Breaking Medicine Technology:
    Cached News: