HOME >> MEDICINE >> NEWS
Mayo Clinic discovers 'new pathway' against pancreatic cancer

ROCHESTER, Minn. -- Pancreatic cancer kills 30,000 Americans every year. Not only is there no cure, but there are no effective treatments. That may change if a new finding by Mayo Clinic researchers continues to show promise. In the March 15 issue of the journal Cancer Research, (http://cancerres.aacrjournals.org/future/65.6.shtml) investigators describe discovering a key molecule that controls the growth, spread and survival of pancreatic cancer cells. This is a critical first step toward developing new and better treatments for patients with pancreatic cancer.

"This is a very exciting -- and surprising -- finding," says Daniel Billadeau, Ph.D., lead author of the report. To identify new target molecules with potentially therapeutic impact for a cancer for which there is currently no real useful treatment is incredibly important.

"Based on the literature, you would predict the opposite of what we found. But in fact, we determined that we can decrease a known regulator of cancer cell survival -- in effect, turn this regulator off -- and when we do, the pancreatic cancer cells undergo apoptosis (commit cell suicide) and die."

Significance of the Research

  • With this finding, a new path is cleared for researchers to target these key molecular players with new small molecule inhibitors to block their action, effectively turning off molecules that promote pancreatic cancer growth.

  • The finding may be applied to make pancreatic cells more sensitive to gemcitabine, the sole drug available for treating pancreatic cancer.

  • This discovery may lead to new drug development strategies for other cancers. Additional research will tell whether these same actors play a similar role in the spread of other cancer types.

    The Key Finding

    The Mayo Clinic researchers discovered a previously unrecognized role in pancreatic cancer for
    '"/>



  • Contact: Bob Nellis
    newsbureau@mayo.edu
    507-284-5005
    Mayo Clinic
    15-Mar-2005


    Page: 1 2

    Related medicine news :

    1. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
    2. Mayo Clinic study sets threshold for valve repair surgery
    3. Mayo Clinic researcher calls for improved newborn screening
    4. Mayo Clinic study finds obese kidney donors face few increased risks
    5. Mayo Clinic identifies key cellular process in prostate and other cancers
    6. Clinical breast examination offers modest benefit to breast cancer screening program
    7. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
    8. Clinicians report missing patient information is common
    9. Mayo Clinic discovers a key to low metabolism and major factor in obesity
    10. Clinical trial of Etanercept for Wegeners disease shows no benefit
    11. Mayo Clinic researchers identify new form of muscular dystrophy in adults

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:10/13/2017)... Rock, AR (PRWEB) , ... October 13, 2017 ... ... firm with locations throughout Arkansas that offers insurance and financial preparation services, is ... benefit the Rock City Rescue organization. , Rock City Rescue is a locally ...
    (Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The American ... to become its next President and Chief Executive Officer, succeeding Dr. James C. Puffer ... Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. ...
    (Date:10/13/2017)... ... October 13, 2017 , ... ... Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate ... primary prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. ...
    (Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
    (Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
    Breaking Medicine News(10 mins):
    (Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
    (Date:10/2/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... , and named its founder as Diplomat,s chief information ... Tennessee , will operate under Diplomat subsidiary Envoy ... for health care partners to include IT outsourcing, consulting, ... "In an interoperable world, technology delivers comprehensive insight and ...
    (Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal ... Friday, November 3, 2017, beginning at 7:00 a.m. (CDT) ... a.m. (CDT) / 9:30 a.m. (EDT). In ... guidance for 2018, Hill-Rom executives will also highlight the ... long-range financial outlook through 2020. ...
    Breaking Medicine Technology:
    Cached News: